2019
Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia
Haghighat L, Ionescu CN, Regan CJ, Altin SE, Attaran RR, Mena-Hurtado CI. Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia. Vascular And Endovascular Surgery 2019, 53: 316-324. PMID: 30808262, DOI: 10.1177/1538574419831489.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaDevelopment of CLIMolecular therapyPoor surgical candidatesImpairment of angiogenesisSurgical candidatesMicrovascular changesNovel imaging modalityTreatment optionsMorbid diseaseTranslational medicine studiesTherapyMedicine studiesImaging modalitiesIschemiaDiseasePatientsPathophysiologyArteriogenesisImpairmentTrials
2017
Effects of metformin on endothelial health and erectile dysfunction
Patel JP, Lee EH, Mena CI, Walker CN. Effects of metformin on endothelial health and erectile dysfunction. Translational Andrology And Urology 2017, 6: 556-565. PMID: 28725599, PMCID: PMC5503973, DOI: 10.21037/tau.2017.03.52.Peer-Reviewed Original ResearchErectile dysfunctionAtherosclerotic luminal narrowingEndothelium-dependent vasodilationArteriogenic erectile dysfunctionImpact of metforminEffect of metforminInsulin-resistant statesVasodilatory impairmentMetformin useEndothelial healthLuminal narrowingMetformin treatmentInsulin sensitizersSystemic diseaseClinical studiesHypertension regulationEncouraging dataResistant stateActivity elevationAmerican menRelated factorsFurther studiesMetforminDysfunctionImpairment