2022
Expanding Inpatient Addiction Consult Services Through Accountable Care Organizations for Medicaid Enrollees: A Modeling Study
King C, Cook R, Korthuis P, McCarty D, Morris C, Englander H. Expanding Inpatient Addiction Consult Services Through Accountable Care Organizations for Medicaid Enrollees: A Modeling Study. Journal Of Addiction Medicine 2022, 16: 570-576. PMID: 35135988, PMCID: PMC9357852, DOI: 10.1097/adm.0000000000000972.Peer-Reviewed Original ResearchMeSH KeywordsAccountable Care OrganizationsAftercareHumansInpatientsMedicaidOpioid-Related DisordersPatient DischargeReferral and ConsultationUnited StatesConceptsOpioid use disorderCoordinated Care OrganizationsAccountable care organizationsTreatment engagementHospitalized patientsUse disordersCare organizationsAddiction consult serviceMedicaid accountable care organizationsOut-patient careSubstance use disordersStudy objectiveACS careMore patientsOUD treatmentOUD careOutpatient treatmentConsult serviceMedicaid enrolleesMedicaid patientsTreatment accessMedicaid dataPatientsService careAddiction careDifferences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;
Priest K, King C, Englander H, Lovejoy T, McCarty D. Differences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;. Substance Use & Addiction Journal 2022, 43: 1251-1259. PMID: 35670778, PMCID: PMC10292919, DOI: 10.1080/08897077.2022.2074601.Peer-Reviewed Original ResearchConceptsOpioid use disorderVeterans Health AdministrationWhite patientsUse disordersMOUD deliveryBlack patientsDelivery of buprenorphineType of MOUDRetrospective cohort analysisAcute care hospitalsCOVID-19 pandemic continuesDelivery of medicationsOutpatient clinical environmentLogistic regression modelsMOUD accessAddiction treatment systemCare hospitalStudy cohortSurgical hospitalizationMean ageCohort analysisHospitalizationMOUDPatientsBuprenorphine
2021
Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder
Merlin JS, Khodyakov D, Arnold R, Bulls HW, Dao E, Kapo J, King C, Meier D, Paice J, Ritchie C, Liebschutz JM. Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder. JAMA Network Open 2021, 4: e2139968. PMID: 34962565, DOI: 10.1001/jamanetworkopen.2021.39968.Peer-Reviewed Original ResearchConceptsOpioid use disorderFull agonist opioidsAdvanced cancerUncertain appropriatenessCancer painPalliative careUse disordersCancer pain managementAppropriateness of managementExpert panel consensusConsensus-based guidanceImportant comorbidityOpioid medicationsPain managementMethadone clinicsPainPatientsPanel consensusPrognosisCancerMethadoneDelphi processExpert panelMonthsOpioidsSimulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality
King C, Cook R, Wheelock H, Korthuis P, Leahy J, Goff A, Morris C, Englander H. Simulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality. International Journal Of Drug Policy 2021, 100: 103525. PMID: 34837879, PMCID: PMC8810590, DOI: 10.1016/j.drugpo.2021.103525.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareAnalgesics, OpioidDrug OverdoseFentanylHospitalizationHumansOpioid-Related DisordersPatient DischargeReferral and ConsultationConceptsAddiction consult serviceOpioid use disorderDrug-related deathsConsult serviceHospital dischargeCare systemDrug-related causesOpioid-related deathsDrug supplyRisk of overdoseDrug-related mortalityOpioid overdose deathsHarm reduction interventionsAdult patientsOUD patientsHospital admissionOpioid overdosesEffective treatmentOverdose deathsSimulated cohortPatientsUse disordersReduction interventionsHospitalizationDeathCorrelates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam
Button D, Cook R, King C, Khuyen T, Kunkel L, Bart G, Thuy D, Nguyen D, Blazes C, Giang L, Korthuis P. Correlates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam. International Journal Of Drug Policy 2021, 100: 103503. PMID: 34768124, PMCID: PMC8810676, DOI: 10.1016/j.drugpo.2021.103503.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHIV InfectionsHumansMaleMethadoneOpiate Substitution TreatmentOpioid-Related DisordersVietnamConceptsMethadone maintenance therapyTreatment exposureMultivariate modelOpioid use disorderDisorder exposureHIV clinicMaintenance therapyPrimary outcomeUse disordersNegative binomial regressionMOUDHIVMedicationsBinomial regressionPatientsExposureDaysMonthsOUDParticipantsBuprenorphineMethadoneClinicReferralTherapyAssociations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease
Cook R, Torralva R, King C, Lum P, Tookes H, Foot C, Vergara-Rodriguez P, Rodriguez A, Fanucchi L, Lucas G, Waddell E, Korthuis P. Associations between fentanyl use and initiation, persistence, and retention on medications for opioid use disorder among people living with uncontrolled HIV disease. Drug And Alcohol Dependence 2021, 228: 109077. PMID: 34600253, PMCID: PMC8595584, DOI: 10.1016/j.drugalcdep.2021.109077.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineDelayed-Action PreparationsFentanylHIV InfectionsHumansMaleMiddle AgedNaltrexoneNarcotic AntagonistsOpioid-Related DisordersConceptsUncontrolled HIV diseaseFentanyl useOpioid use disorderXR-NTXHIV diseaseUse disordersTreatment of OUDUncontrolled HIV infectionExtended-release naltrexoneHIV viral suppressionUrine drug screeningExposure of interestMultisite clinical trialPercent of participantsMethadone administrationMOUD initiationMOUD retentionViral suppressionBuprenorphine prescriptionsHIV infectionClinical trialsWeek 20First injectionAdministrationMOUDDesigning and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality
King C, Englander H, Korthuis P, Barocas J, McConnell K, Morris C, Cook R. Designing and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality. PLOS ONE 2021, 16: e0256793. PMID: 34506517, PMCID: PMC8432751, DOI: 10.1371/journal.pone.0256793.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleHospitalizationHumansMaleMarkov ChainsMiddle AgedOpioid-Related DisordersOregonConceptsAddiction consult serviceOpioid use disorderDrug-related deathsHospitalized patientsOUD careRelated mortalityPercent of patientsNon-drug related deathTrajectory of careSubstance use treatmentLogistic regression modelsACS careOUD treatmentPatient survivalRelated deathsSUD careConsult serviceMedicaid dataPatientsUse disordersMortalityUse treatmentCareBayesian logistic regression modelDeathCauses of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder
King C, Cook R, Korthuis P, Morris C, Englander H. Causes of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder. Journal Of Addiction Medicine 2021, 16: 466-469. PMID: 34510087, PMCID: PMC8907339, DOI: 10.1097/adm.0000000000000915.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAftercareAnalgesics, OpioidCause of DeathDrug OverdoseFemaleHospitalsHumansOpioid-Related DisordersPatient DischargeUnited StatesConceptsOpioid use disorderCause of deathDrug-related deathsUse disordersHospitalized patientsDiagnosis of OUDGeneral hospital admissionsPost-discharge mortalityDrug-related causesAverage hospital lengthRisk of deathSubstance use disordersHospital lengthHospital dischargeHospital admissionMedicaid insuranceOUD diagnosisDrug overdoseMedicaid patientsFrequent causeHigh riskGeneral populationPatientsAverage ageCare systemConsensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process
King C, Arnold R, Dao E, Kapo J, Liebschutz J, Meier D, Paice J, Ritchie C, Czajkowski K, Khodyakov D, Merlin J. Consensus-based approach to managing opioids, including opioid misuse and opioid use disorder, in patients with serious illness: protocol for a modified Delphi process. BMJ Open 2021, 11: e045402. PMID: 34011593, PMCID: PMC8137210, DOI: 10.1136/bmjopen-2020-045402.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidConsensusDelphi TechniqueHumansOpioid-Related DisordersPain ManagementConceptsOpioid use disorderOpioid misuseSerious illnessInstitutional review boardUse disordersBenefits of opioidsOpioid-related harmsPalliative care cliniciansInstitutional Research BoardPittsburgh Institutional Review BoardOpioid therapyPain managementCare cliniciansPalliative careClinical guidanceEthical approvalIllnessReview boardCliniciansDelphi processPatient casesImplementation toolkitRound 1OpioidsFinal consensusIncarceration and compulsory rehabilitation impede use of medication for opioid use disorder and HIV care engagement in Vietnam
King C, Cook R, Giang L, Bart G, Hoffman K, Waddell E, Korthuis P. Incarceration and compulsory rehabilitation impede use of medication for opioid use disorder and HIV care engagement in Vietnam. Journal Of Substance Use And Addiction Treatment 2021, 134: 108451. PMID: 33962813, PMCID: PMC8558110, DOI: 10.1016/j.jsat.2021.108451.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHIV InfectionsHumansMethadoneOpiate Substitution TreatmentOpioid-Related DisordersVietnamConceptsOpioid use disorderMonth 9Use disordersClinic engagementAntiretroviral therapy prescriptionNon-prescribed opioid useCompulsory rehabilitationHIV treatment outcomesHIV viral suppressionHIV care engagementUse of medicationsNon-prescribed opioidsCompulsory rehabilitation centersEvidence-based strategiesHIV clinicViral suppressionOpioid useHIV treatmentCare engagementMonths 0Therapy prescriptionClinical trialsTreatment outcomesTreatment accessMOUDHIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial
Korthuis P, King C, Cook R, Khuyen T, Kunkel L, Bart G, Nguyen T, Thuy D, Bielavitz S, Nguyen D, Tam N, Giang L. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. The Lancet HIV 2021, 8: e67-e76. PMID: 33539760, PMCID: PMC8082651, DOI: 10.1016/s2352-3018(20)30302-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBuprenorphineCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedNaloxoneNarcotic AntagonistsNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersPatient ComplianceRandom AllocationRNA, ViralTreatment OutcomeVietnamViral LoadConceptsMethadone maintenance therapyOpioid use disorderHIV viral suppressionMaintenance therapySerious adverse eventsViral suppressionAdverse eventsNon-inferiority trialUse disordersHIV clinicNaloxone treatmentComputer-generated random number sequenceOpioid use disorder medicationsTreatment-emergent adverse eventsHIV clinic visitsQuarterly study visitsBuprenorphine adherenceCD4 countHIV careClinic visitsBuprenorphine treatmentHIV outcomesMiddle-income countriesPrimary outcomeMean age
2020
Patterns of substance use before and after hospitalization among patients seen by an inpatient addiction consult service: A latent transition analysis
King C, Nicolaidis C, Korthuis P, Priest K, Englander H. Patterns of substance use before and after hospitalization among patients seen by an inpatient addiction consult service: A latent transition analysis. Journal Of Substance Use And Addiction Treatment 2020, 118: 108121. PMID: 32972645, PMCID: PMC8244750, DOI: 10.1016/j.jsat.2020.108121.Peer-Reviewed Original ResearchMeSH KeywordsHospitalizationHumansInpatientsOpioid-Related DisordersOregonProspective StudiesSubstance-Related DisordersConceptsAddiction consult serviceSubstance use disordersHospitalized patientsPolysubstance useUse disordersSubstance useOpioid useConsult serviceBaseline opioid useHalf of patientsProspective cohort studyOpioid use disorderSelf-reported substance useSubstance use scoresDays posthospitalizationCohort studyHospital admissionClinical managementDifferent followHealth centersAmphetamine useLatent transition analysisPatientsAcademic health centersHospital providersHIV care continuum characteristics among people with opioid use disorder and HIV in Vietnam: baseline results from the BRAVO study
King C, Giang L, Bart G, Kunkel L, Korthuis P. HIV care continuum characteristics among people with opioid use disorder and HIV in Vietnam: baseline results from the BRAVO study. BMC Public Health 2020, 20: 421. PMID: 32228522, PMCID: PMC7106608, DOI: 10.1186/s12889-020-08538-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnti-Retroviral AgentsBuprenorphineContinuity of Patient CareFemaleHIV InfectionsHumansLogistic ModelsMaleMethadoneMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CareRandomized Controlled Trials as TopicVietnamViral LoadConceptsHIV viral suppressionOpioid use disorderReceipt of ARTAntiretroviral therapyViral suppressionUse disordersART statusParticipant characteristicsHIV care continuumBaseline participant characteristicsGreater depression symptomsLogistic regression modelsART initiationHIV peopleHIV diagnosisPatient characteristicsClinical trialsCare continuumDepression symptomsStudy participantsCurrent prescriptionDisordersBaselineRegression modelsPrimary objective
2019
Predictors of Opioid and Alcohol Pharmacotherapy Initiation at Hospital Discharge Among Patients Seen by an Inpatient Addiction Consult Service.
Englander H, King C, Nicolaidis C, Collins D, Patten A, Gregg J, Korthuis P. Predictors of Opioid and Alcohol Pharmacotherapy Initiation at Hospital Discharge Among Patients Seen by an Inpatient Addiction Consult Service. Journal Of Addiction Medicine 2019, 14: 415-422. PMID: 31868830, PMCID: PMC7954140, DOI: 10.1097/adm.0000000000000611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidHospitalsHumansInpatientsOpioid-Related DisordersPatient DischargeConceptsImproving Addiction Care TeamAddiction consult serviceSubstance use disordersUse disordersConsult serviceTreatment-related factorsOpioid use disorderMethadone maintenance treatmentAcademic medical centerAlcohol use disorderPartner substance useSevere OUDMedication initiationPatient demographicsMaintenance treatmentPatient surveyCare teamClinical dataMedical CenterSocial determinantsLogistic regressionHospital's roleSubstance useDisordersPatients