2022
A Comparison of Patient- and Clinician-Reported Acute Toxic Effects During Radiation Therapy for Primary Breast Cancer
Lapen K, King C, Braunstein L, Khan A, Kamrava M, Gillespie E, Cook K. A Comparison of Patient- and Clinician-Reported Acute Toxic Effects During Radiation Therapy for Primary Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: 301-309. PMID: 35675851, PMCID: PMC10281649, DOI: 10.1016/j.ijrobp.2022.05.041.Peer-Reviewed Original ResearchConceptsPrimary breast cancerRadiation therapyAcute toxic effectsClinician assessmentBreast cancerPatients warrants further investigationTreatment-related toxic effectsToxic effectsPatient-clinician pairsSymptom burden scoresCommon Terminology CriteriaComparison of patientsStart of treatmentBreast radiation therapyWarrants further investigationTerminology CriteriaAdverse eventsSymptom burdenOutcomes versionPatients' qualityBurden scoreProspective studyUnique patientsLow-severity symptomsPatient responseDifferences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;
Priest K, King C, Englander H, Lovejoy T, McCarty D. Differences in the Delivery of Medications for Opioid use Disorder during Hospitalization by Racial Categories: A Retrospective Cohort Analysis;. Substance Use & Addiction Journal 2022, 43: 1251-1259. PMID: 35670778, PMCID: PMC10292919, DOI: 10.1080/08897077.2022.2074601.Peer-Reviewed Original ResearchConceptsOpioid use disorderVeterans Health AdministrationWhite patientsUse disordersMOUD deliveryBlack patientsDelivery of buprenorphineType of MOUDRetrospective cohort analysisAcute care hospitalsCOVID-19 pandemic continuesDelivery of medicationsOutpatient clinical environmentLogistic regression modelsMOUD accessAddiction treatment systemCare hospitalStudy cohortSurgical hospitalizationMean ageCohort analysisHospitalizationMOUDPatientsBuprenorphine
2021
Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder
Merlin JS, Khodyakov D, Arnold R, Bulls HW, Dao E, Kapo J, King C, Meier D, Paice J, Ritchie C, Liebschutz JM. Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder. JAMA Network Open 2021, 4: e2139968. PMID: 34962565, DOI: 10.1001/jamanetworkopen.2021.39968.Peer-Reviewed Original ResearchConceptsOpioid use disorderFull agonist opioidsAdvanced cancerUncertain appropriatenessCancer painPalliative careUse disordersCancer pain managementAppropriateness of managementExpert panel consensusConsensus-based guidanceImportant comorbidityOpioid medicationsPain managementMethadone clinicsPainPatientsPanel consensusPrognosisCancerMethadoneDelphi processExpert panelMonthsOpioidsDesigning and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality
King C, Englander H, Korthuis P, Barocas J, McConnell K, Morris C, Cook R. Designing and validating a Markov model for hospital-based addiction consult service impact on 12-month drug and non-drug related mortality. PLOS ONE 2021, 16: e0256793. PMID: 34506517, PMCID: PMC8432751, DOI: 10.1371/journal.pone.0256793.Peer-Reviewed Original ResearchConceptsAddiction consult serviceOpioid use disorderDrug-related deathsHospitalized patientsOUD careRelated mortalityPercent of patientsNon-drug related deathTrajectory of careSubstance use treatmentLogistic regression modelsACS careOUD treatmentPatient survivalRelated deathsSUD careConsult serviceMedicaid dataPatientsUse disordersMortalityUse treatmentCareBayesian logistic regression modelDeathCauses of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder
King C, Cook R, Korthuis P, Morris C, Englander H. Causes of Death in the 12 Months After Hospital Discharge Among Patients With Opioid Use Disorder. Journal Of Addiction Medicine 2021, 16: 466-469. PMID: 34510087, PMCID: PMC8907339, DOI: 10.1097/adm.0000000000000915.Peer-Reviewed Original ResearchConceptsOpioid use disorderCause of deathDrug-related deathsUse disordersHospitalized patientsDiagnosis of OUDGeneral hospital admissionsPost-discharge mortalityDrug-related causesAverage hospital lengthRisk of deathSubstance use disordersHospital lengthHospital dischargeHospital admissionMedicaid insuranceOUD diagnosisDrug overdoseMedicaid patientsFrequent causeHigh riskGeneral populationPatientsAverage ageCare systemA hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment
Seaman A, King C, Kaser T, Geduldig A, Ronan W, Cook R, Chan B, Levander X, Priest K, Korthuis P. A hepatitis C elimination model in healthcare for the homeless organization: A novel reflexive laboratory algorithm and equity assessment. International Journal Of Drug Policy 2021, 96: 103359. PMID: 34325969, PMCID: PMC8720290, DOI: 10.1016/j.drugpo.2021.103359.Peer-Reviewed Original ResearchConceptsDirect acting antiviralsLogistic regression modelsCascade progressionHepatitis C elimination targetsCox proportional hazards modelMultiple logistic regression modelHCV care cascadeHCV treatment cascadeSingle blood drawPresence of opioidsLikelihood of screeningProportional hazards modelTreatment of peopleHCV screeningCare cascadeHCV treatmentActing antiviralsBundle interventionsMultinomial logistic regression modelsPatient characteristicsHCV PCRTreatment cascadeTreatment initiationHomeless clinicRegression modelsUnderstanding the impact of the SARS-COV-2 pandemic on hospitalized patients with substance use disorder
King C, Vega T, Button D, Nicolaidis C, Gregg J, Englander H. Understanding the impact of the SARS-COV-2 pandemic on hospitalized patients with substance use disorder. PLOS ONE 2021, 16: e0247951. PMID: 33635926, PMCID: PMC7909702, DOI: 10.1371/journal.pone.0247951.Peer-Reviewed Original ResearchConceptsSubstance use disordersSARS-CoV-2 pandemicHospitalized patientsUse disordersHospital policy changesAcademic medical centerExperiences of healthcareAcute illnessOutpatient careMedical CenterPatientsHospitalCommunity resourcesDisordersPandemicQualitative studyThematic analysisSemi-structured interviewsSurvival adaptationHospitalizationIllnessMain themesCareHIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial
Korthuis P, King C, Cook R, Khuyen T, Kunkel L, Bart G, Nguyen T, Thuy D, Bielavitz S, Nguyen D, Tam N, Giang L. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial. The Lancet HIV 2021, 8: e67-e76. PMID: 33539760, PMCID: PMC8082651, DOI: 10.1016/s2352-3018(20)30302-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBuprenorphineCD4 Lymphocyte CountDrug Therapy, CombinationFemaleHIV InfectionsHumansMaleMethadoneMiddle AgedNaloxoneNarcotic AntagonistsNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersPatient ComplianceRandom AllocationRNA, ViralTreatment OutcomeVietnamViral LoadConceptsMethadone maintenance therapyOpioid use disorderHIV viral suppressionMaintenance therapySerious adverse eventsViral suppressionAdverse eventsNon-inferiority trialUse disordersHIV clinicNaloxone treatmentComputer-generated random number sequenceOpioid use disorder medicationsTreatment-emergent adverse eventsHIV clinic visitsQuarterly study visitsBuprenorphine adherenceCD4 countHIV careClinic visitsBuprenorphine treatmentHIV outcomesMiddle-income countriesPrimary outcomeMean age
2020
Evaluating new paralysis, mortality, and readmission among subgroups of patients with spinal epidural abscess: A latent class analysis
Brown P, Phillipi G, King C, Tanski M, Sullivan P. Evaluating new paralysis, mortality, and readmission among subgroups of patients with spinal epidural abscess: A latent class analysis. PLOS ONE 2020, 15: e0238853. PMID: 32915861, PMCID: PMC7485888, DOI: 10.1371/journal.pone.0238853.Peer-Reviewed Original ResearchConceptsSpinal epidural abscessSubgroup of patientsClinical outcomesPatient populationGroup 2Group 1Longer hospital courseSubstance use disorder diagnosisLatent class analysisSubstance use disordersChi-square testCharacteristics of subgroupsHospital mortalityEpidural abscessHospital courseMedical comorbiditiesSignificant morbidityVascular accessRisk factorsClinical subgroupsHealth centersSupport patientsHigh riskPatientsSubsequent mortalityCommunity-derived recommendations for healthcare systems and medical students to support people who are houseless in Portland, Oregon: a mixed-methods study
King C, Fisher C, Johnson J, Chun A, Bangsberg D, Carder P. Community-derived recommendations for healthcare systems and medical students to support people who are houseless in Portland, Oregon: a mixed-methods study. BMC Public Health 2020, 20: 1337. PMID: 32878612, PMCID: PMC7466795, DOI: 10.1186/s12889-020-09444-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude to HealthBehavior, AddictiveDelivery of Health CareFemaleHealth Services Needs and DemandHousingHumansIll-Housed PersonsMaleMental DisordersMental HealthMiddle AgedOregonPatient AdvocacyPopulation HealthProfessional-Patient RelationsQualitative ResearchSocial ChangeSocial StigmaSocial SupportStudents, MedicalSubstance-Related DisordersSurveys and QuestionnairesConceptsCommunity-based organizationsQualitative interview guideSelf-identified needsMixed-methods surveyInstitutional levelSemi-structured qualitative interview guideHouselessMixed-methods studyQualitative dataDisproportionate disparitiesThematic analysisInstitutionsQualitative themesInterview guideHouselessnessTraining institutionsPeopleCare experiencesHealth of peopleHealthcare systemTime of interviewMental health conditionsSubstance use disordersCommunityStigmaCommunity Outreach for Navajo People Living with Diabetes: Who Benefits Most?
Trevisi L, Orav J, Atwood S, Brown C, Curley C, King C, Muskett O, Sehn H, Nelson A, Begay M, Shin S. Community Outreach for Navajo People Living with Diabetes: Who Benefits Most? Preventing Chronic Disease 2020, 17: e68. PMID: 32701432, PMCID: PMC7380292, DOI: 10.5888/pcd17.200068.Peer-Reviewed Original ResearchConceptsPrimary care providersBaseline HbACommunity Health RepresentativesMental health conditionsCare providersCOPE patientsHealth conditionsGlycated hemoglobin APrimary care physiciansRoutine health recordsPatient empowerment interventionCommunity outreachDe-identified dataPreferred languageCare physiciansCOPE interventionPatientsHealth representativesDiabetesHealth recordsHemoglobin AHbALinear mixed modelsInterventionEmpowerment interventionHIV care continuum characteristics among people with opioid use disorder and HIV in Vietnam: baseline results from the BRAVO study
King C, Giang L, Bart G, Kunkel L, Korthuis P. HIV care continuum characteristics among people with opioid use disorder and HIV in Vietnam: baseline results from the BRAVO study. BMC Public Health 2020, 20: 421. PMID: 32228522, PMCID: PMC7106608, DOI: 10.1186/s12889-020-08538-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnti-Retroviral AgentsBuprenorphineContinuity of Patient CareFemaleHIV InfectionsHumansLogistic ModelsMaleMethadoneMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CareRandomized Controlled Trials as TopicVietnamViral LoadConceptsHIV viral suppressionOpioid use disorderReceipt of ARTAntiretroviral therapyViral suppressionUse disordersART statusParticipant characteristicsHIV care continuumBaseline participant characteristicsGreater depression symptomsLogistic regression modelsART initiationHIV peopleHIV diagnosisPatient characteristicsClinical trialsCare continuumDepression symptomsStudy participantsCurrent prescriptionDisordersBaselineRegression modelsPrimary objectiveTime-to-completed-imaging, survival and function in patients with spinal epidural abscess: Description of a series of 34 patients, 2015–2018
King C, Fisher C, Brown P, Priest K, Tanski M, Sullivan P. Time-to-completed-imaging, survival and function in patients with spinal epidural abscess: Description of a series of 34 patients, 2015–2018. BMC Health Services Research 2020, 20: 119. PMID: 32059715, PMCID: PMC7023770, DOI: 10.1186/s12913-020-4973-5.Peer-Reviewed Original ResearchConceptsIntravenous drug useDrug useEpidural abscessEmergency departmentRisk factorsMethodsThis retrospective cohort studySingle academic medical centerMean timeRetrospective cohort studySpinal epidural abscessLife-threatening infectionsAcademic medical centerMulti-center approachShorter mean timeCohort studyNeurologic symptomsBack painClassic triadSignificant morbiditySurgical interventionSingle hospitalQuality improvement workMedical CenterPrompt identificationPatients
2019
Integrating community health representatives with health care systems: clinical outcomes among individuals with diabetes in Navajo Nation
Trevisi L, Orav J, Atwood S, Brown C, Curley C, King C, Muskett O, Sehn H, Nelson K, Begay M, Shin S. Integrating community health representatives with health care systems: clinical outcomes among individuals with diabetes in Navajo Nation. International Journal For Equity In Health 2019, 18: 183. PMID: 31771603, PMCID: PMC6880375, DOI: 10.1186/s12939-019-1097-9.Peer-Reviewed Original ResearchConceptsCommunity Health RepresentativesClinical outcomesHealth representativesSystolic blood pressureBody mass indexRoutine clinical dataLow-density lipoproteinIntegrated care teamsPatient empowerment interventionHealth care systemHealth service information systemCOPE groupCOPE patientsClinical characteristicsBlood pressureDiabetes mellitusMass indexCare teamClinical dataLipid levelsHome visitsCOPE interventionNavajo populationPatientsClinical sites
2018
Glycemic control and healthcare utilization following pregnancy among women with pre-existing diabetes in Navajo Nation
Ho J, Bachman-Carter K, Thorkelson S, Anderson K, Jaggi J, Brown C, Nelson A, Curley C, King C, Atwood S, Shin S. Glycemic control and healthcare utilization following pregnancy among women with pre-existing diabetes in Navajo Nation. BMC Health Services Research 2018, 18: 629. PMID: 30097012, PMCID: PMC6086058, DOI: 10.1186/s12913-018-3434-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArizonaBlood GlucoseDiabetes Mellitus, Type 2Facilities and Services UtilizationFemaleGlycated HemoglobinHealth Services, IndigenousHumansIndians, North AmericanLogistic ModelsMiddle AgedNew MexicoPatient Acceptance of Health CarePostnatal CarePregnancyPregnancy in DiabeticsPrenatal CareRetrospective StudiesUnited StatesUtahYoung AdultConceptsPre-existing diabetesGlycemic controlIndian Health Service HospitalSpecialized prenatal careRetrospective chart reviewPatient-level predictorsPrimary care providersImmediate postpartum periodResultsOne hundred twentyType 2 diabetesContinuity of healthcareTribal Health SystemBaseline HbA1cChart reviewPrimary outcomeHealthcare utilizationPrenatal carePostpartum periodPregnancy periodHundred twentyService hospitalsCare providersGeneral populationOnly covariatePregnancyIdentifying risk factors for 30-day readmission events among American Indian patients with diabetes in the Four Corners region of the southwest from 2009 to 2016
King C, Atwood S, Lozada M, Nelson A, Brown C, Sabo S, Curley C, Muskett O, Orav E, Shin S. Identifying risk factors for 30-day readmission events among American Indian patients with diabetes in the Four Corners region of the southwest from 2009 to 2016. PLOS ONE 2018, 13: e0195476. PMID: 30070989, PMCID: PMC6071952, DOI: 10.1371/journal.pone.0195476.Peer-Reviewed Original Research
2017
Primary care and survival among American Indian patients with diabetes in the Southwest United States: Evaluation of a cohort study at Gallup Indian Medical Center, 2009–2016
King C, Atwood S, Brown C, Nelson A, Lozada M, Wei J, Merino M, Curley C, Muskett O, Sabo S, Gampa V, Orav J, Shin S. Primary care and survival among American Indian patients with diabetes in the Southwest United States: Evaluation of a cohort study at Gallup Indian Medical Center, 2009–2016. Primary Care Diabetes 2017, 12: 212-217. PMID: 29229284, DOI: 10.1016/j.pcd.2017.11.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overCause of DeathChildCohort StudiesDatabases, FactualDiabetes MellitusFemaleHospitalizationHumansIndians, North AmericanKaplan-Meier EstimateMaleMiddle AgedPrimary Health CareProportional Hazards ModelsRetrospective StudiesRisk AssessmentSex FactorsSouthwestern United StatesStatistics, NonparametricSurvival AnalysisYoung AdultConceptsPrimary care providersLog-rank testAmerican Indian patientsCare providersIndian patientsCox proportional hazards analysisStudy periodProportional hazards analysisMedian survival timeCause mortalityCohort studyOverall survivalImproved survivalFirst admissionUnadjusted analysesPrimary careMedical CenterSurvival timePatientsAdmissionDiabetesSurvivalHealthcare deliverySignificant differencesHazard analysisSurgical referral coordination from a first-level hospital: a prospective case study from rural Nepal
Fleming M, King C, Rajeev S, Baruwal A, Schwarz D, Schwarz R, Khadka N, Pande S, Khanal S, Acharya B, Benton A, Rogers SO, Panizales M, Gyorki D, McGee H, Shaye D, Maru D. Surgical referral coordination from a first-level hospital: a prospective case study from rural Nepal. BMC Health Services Research 2017, 17: 676. PMID: 28946885, PMCID: PMC5613391, DOI: 10.1186/s12913-017-2624-2.Peer-Reviewed Original ResearchConceptsHealth systems frameworkWorld Health Organization health systems frameworkFirst-level hospitalsProspective case studySurgical careSurgical servicesReferral systemGeneral surgical conditionsCare coordination processLocal surgical capacityRural NepalComprehensive surgical careSurgical specialty servicesDistrict hospitalSurgical conditionsSpecialty servicesSurgical capacityReferral processDiagnostic examinationsCoordination programPatientsHospitalReferral coordinationIndirect costsCommon typeStrengthening the role of Community Health Representatives in the Navajo Nation
King C, Goldman A, Gampa V, Smith C, Muskett O, Brown C, Malone J, Sehn H, Curley C, Begay M, Nelson A, Shin S. Strengthening the role of Community Health Representatives in the Navajo Nation. BMC Public Health 2017, 17: 348. PMID: 28431541, PMCID: PMC5399395, DOI: 10.1186/s12889-017-4263-2.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelCommunity Health WorkersCommunity-Institutional RelationsCross-Sectional StudiesFemaleFocus GroupsHealth Services, IndigenousHumansIndians, North AmericanLongitudinal StudiesMaleOrganizations, NonprofitPatient ParticipationProfessional RoleProgram EvaluationSouthwestern United StatesConceptsCommunity health worker systemLongitudinal cohort studyCommunity health workersPublic health nursesCommunity Health RepresentativesHigh-risk individualsHospital-based providersHome-based interventionLocal health care systemHealth promotion materialsHealth care systemElectronic health recordsCohort studyHealth nursesLow-resource communitiesCare coordinationHealth workersSectional evaluationCOPE programHealth representativesHealth outcomesDisease preventionProgrammatic supportCare systemHealth recordsCultural elements underlying the community health representative – client relationship on Navajo Nation
Gampa V, Smith C, Muskett O, King C, Sehn H, Malone J, Curley C, Brown C, Begay M, Shin S, Nelson A. Cultural elements underlying the community health representative – client relationship on Navajo Nation. BMC Health Services Research 2017, 17: 19. PMID: 28069014, PMCID: PMC5223387, DOI: 10.1186/s12913-016-1956-7.Peer-Reviewed Original ResearchConceptsCommunity Health RepresentativesCultural elementsCommunity health workersNavajo NationMethodsIn-depth interviewsMarginalized communitiesSocial practicesIndigenous communitiesClient familiesCommunity partnersRelevant themesHealth representativesNationsCommunityCrucial servicesInterviewsPositive health outcomesQuality servicesTrustHealth workersNarrativesClientsTraditionCHR programsServices