Featured Publications
Representation of American Indian and Alaska Native Individuals in Academic Medical Training
Forrest LL, Leitner BP, Guzman C, Brodt E, Odonkor CA. Representation of American Indian and Alaska Native Individuals in Academic Medical Training. JAMA Network Open 2022, 5: e2143398. PMID: 35024836, PMCID: PMC8759009, DOI: 10.1001/jamanetworkopen.2021.43398.Peer-Reviewed Original Research
2024
The thermoneutral zone in women takes an “arctic” shift compared to men
Brychta R, McGehee S, Huang S, Leitner B, Duckworth C, Fletcher L, Kim K, Cassimatis T, Israni N, Lea H, Lentz T, Pierce A, Jiang A, LaMunion S, Thomas R, Ishihara A, Courville A, Yang S, Reitman M, Cypess A, Chen K. The thermoneutral zone in women takes an “arctic” shift compared to men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2311116121. PMID: 38683977, PMCID: PMC11087792, DOI: 10.1073/pnas.2311116121.Peer-Reviewed Original Research
2021
Diversity of Pain Medicine Trainees and Faculty in the United States: A Cross-Sectional Analysis of Fellowship Training from 2009–2019
Odonkor CA, Leitner B, Taraben S, Adekoya P, Orhurhu V, Hirani S, Ike K, Lee R, Vanterpool S, Goree JH, Sully K, Poree L. Diversity of Pain Medicine Trainees and Faculty in the United States: A Cross-Sectional Analysis of Fellowship Training from 2009–2019. Pain Medicine 2021, 22: 819-828. PMID: 33502490, PMCID: PMC8599803, DOI: 10.1093/pm/pnab004.Peer-Reviewed Original ResearchConceptsPain fellowsCross-sectional retrospective analysisPain fellowship programsPain medicine fellowsNative Americans/Alaskan NativesRatio of menCross-sectional analysisRetrospective analysisLower oddsMedicine training programsMedical CollegeFellowship traineesPractice settingsMedicine traineesAlaskan NativesGraduate Medical EducationSignificant differencesUnited StatesFellowship programsAccreditation CouncilAmerican AssociationEthnicity compositionSexUnited States Accreditation CouncilTraining program
2020
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
O'Mara A, Johnson J, Linderman J, Brychta R, McGehee S, Fletcher L, Fink Y, Kapuria D, Cassimatis T, Kelsey N, Cero C, Sater Z, Piccinini F, Baskin A, Leitner B, Cai H, Millo C, Dieckmann W, Walter M, Javitt N, Rotman Y, Walter P, Ader M, Bergman R, Herscovitch P, Chen K, Cypess A. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. Journal Of Clinical Investigation 2020, 130: 2209-2219. PMID: 31961826, PMCID: PMC7190915, DOI: 10.1172/jci131126.Peer-Reviewed Original ResearchConceptsBAT metabolic activityIntravenous glucose tolerance testGlucose tolerance testΒ3-AR agonistInsulin sensitivityTolerance testMetabolic diseasesObesity-related metabolic diseasesWhite adipose tissue lipolysisBrown adipose tissue thermogenesisOpen-label studyTotal bile acidsHuman brown fatHigher insulin sensitivityAdipose tissue lipolysisAdipose tissue thermogenesisPET/CTΒ3-adrenergic receptor agonistIntramural Research ProgramChronic pharmacological stimulationMetabolic activityMirabegron therapyMirabegron treatmentPrimary endpointSecondary endpointsSexual Dimorphisms in Adult Human Brown Adipose Tissue
Fletcher L, Kim K, Leitner B, Cassimatis T, O’Mara A, Johnson J, Halprin M, McGehee S, Brychta R, Cypess A, Chen K. Sexual Dimorphisms in Adult Human Brown Adipose Tissue. Obesity 2020, 28: 241-246. PMID: 31970907, PMCID: PMC6986330, DOI: 10.1002/oby.22698.Peer-Reviewed Original ResearchConceptsBrown adipose tissueF-fluorodeoxyglucose uptakeBAT volumeAdipose tissueAdult human brown adipose tissueCold-activated brown adipose tissueInterscapular brown adipose tissueGlucose uptakeTotal BAT volumeHuman brown adipose tissueBAT glucose uptakeBody weight regulationPositron emission tomographyOvert shiveringDistribution of BATLean womenAnatomical distributionBAT depotsWeight regulationHours of exposureHuman newbornsComputerized tomographyEmission tomographyYoung womenWomen
2018
Exercise modulates the interaction between cognition and anxiety in humans
Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Balderston NL, Chen KY, Grillon C, Ernst M. Exercise modulates the interaction between cognition and anxiety in humans. Cognition & Emotion 2018, 33: 863-870. PMID: 30032703, PMCID: PMC6344312, DOI: 10.1080/02699931.2018.1500445.Peer-Reviewed Original ResearchConceptsAnxiety-potentiated startleAttention controlTask-relevant stimulus processingInterplay of cognitionThreat of shockThreat interferenceThreat processingWM loadWM taskMemory loadWM performanceStimulus processingCognitive abilitiesAnxiolytic effectsAnxiety disordersCognitionAnxietyType of activityProcessingFuture studiesStartleTaskHealthy volunteersParticipantsImpairmentKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivationExercise decreases defensive responses to unpredictable, but not predictable, threat
Lago TR, Hsiung A, Leitner BP, Duckworth CJ, Chen KY, Ernst M, Grillon C. Exercise decreases defensive responses to unpredictable, but not predictable, threat. Depression And Anxiety 2018, 35: 868-875. PMID: 29637654, PMCID: PMC6314494, DOI: 10.1002/da.22748.Peer-Reviewed Original ResearchConceptsSessions of exerciseInfluence of exercisePredictable threatSustained responseClinical indicationsHealthy controlsAnxiolytic effectsHealthy volunteersPhasic responseThreat testBehavioral interventionsAnxiety disordersControl activitiesDefensive responsesUnpredictable threatStartle potentiationExercisePotentiationNeurobehavioral mechanismsEyeblink startleResponseUnpredictable shocksProvide cluesDefensive stateThreat responses