Featured Publications
Mapping of human brown adipose tissue in lean and obese young men
Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY. Mapping of human brown adipose tissue in lean and obese young men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8649-8654. PMID: 28739898, PMCID: PMC5559032, DOI: 10.1073/pnas.1705287114.Peer-Reviewed Original ResearchConceptsBrown adipose tissueHuman brown adipose tissueAdipose tissueActivity of BATPositron emission tomography/computerized tomographyTomography/computerized tomographyActivated Brown Adipose TissueFluorodeoxyglucose positron emission tomography/computerized tomographyActive brown adipose tissueCold exposureSpecific adipose depotsObese young menHealthy young menYoung menAcute cold exposureLean menObese menBAT volumeTotal body massThermogenic potentialAdipose depotsAnatomic characteristicsFascial layersMetabolic diseasesComputerized tomography
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rate