MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate
Israni N, Cassimatis T, Fletcher L, Leitner B, Duckworth C, Hattenbach J, Bell S, McGehee S, Brychta R, Courville A, Bernstein S, Muniyappa R, Reitman M, Cypess A, Chen K. MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate. Journal Of The Endocrine Society 2020, 4: mon-593. PMCID: PMC7209218, DOI: 10.1210/jendso/bvaa046.366.Peer-Reviewed Original ResearchAnti-obesity drugsHeart rateBasal metabolic rateEnergy expenditureRespiratory quotientSympathetic nervous system activityRandomized cross-over studyPrespecified primary outcomeSingle-dose effectsDrug-naïve subjectsCross-over studyClinical research unitNervous system activityWhole-room indirect calorimeterLong-term interventionsSelf-reported hungerSecondary outcomesArterial pressureHunger scoresPrimary outcomeWashout periodAppetite suppressionChronic useSingle doseAcute effects