2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological features
2021
Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India
Pandit B, Bhattacharjee S, Bhattacharjee B. Association of clade-G SARS-CoV-2 viruses and age with increased mortality rates across 57 countries and India. Infection Genetics And Evolution 2021, 90: 104734. PMID: 33508515, PMCID: PMC7839510, DOI: 10.1016/j.meegid.2021.104734.Peer-Reviewed Original ResearchConceptsIndication of population expansionNegative Tajima's D valuesAllele frequency spectrumTajima's D valuesSARS-CoV-2 sequencesAmino acid changesClade of virusesNucleotide diversityEvolutionary analysisLinkage disequilibriumPopulation expansionContribution of host factorsViral haplotypesClade GAcid changesSARS-CoV-2 variantsViral populationsHost factorsMortality rateVariantsViral factorsNetwork analysisCoronary heart diseaseSARS-CoV-2 virusVirus