Featured Publications
Control of cell state transitions
Rukhlenko O, Halasz M, Rauch N, Zhernovkov V, Prince T, Wynne K, Maher S, Kashdan E, MacLeod K, Carragher N, Kolch W, Kholodenko B. Control of cell state transitions. Nature 2022, 609: 975-985. PMID: 36104561, PMCID: PMC9644236, DOI: 10.1038/s41586-022-05194-y.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell ProliferationDatasets as TopicModels, BiologicalPhenotypeSignal TransductionSingle-Cell AnalysisWorkflowConceptsCell state transitionsCell fateCell statesCell fate transitionsCell fate decisionsSingle-cell dataNew biological insightsFate transitionsMovement of cellsFate decisionsWaddington landscapePhenotypic dataBiological insightsOmics datasetsOmics dataCellular modelMechanistic modelLandscape1FateCellsDevelopment pathwaysLandscapeBiologyState transitionsTherapeutic interventions
2023
Reversing pathological cell states: the road less travelled can extend the therapeutic horizon
Kholodenko B, Kolch W, Rukhlenko O. Reversing pathological cell states: the road less travelled can extend the therapeutic horizon. Trends In Cell Biology 2023, 33: 913-923. PMID: 37263821, PMCID: PMC10593090, DOI: 10.1016/j.tcb.2023.04.004.Peer-Reviewed Original Research
2015
Frequency modulation of ERK activation dynamics rewires cell fate
Ryu H, Chung M, Dobrzyński M, Fey D, Blum Y, Lee SS, Peter M, Kholodenko BN, Jeon NL, Pertz O. Frequency modulation of ERK activation dynamics rewires cell fate. Molecular Systems Biology 2015, 11: msb156458. PMID: 26613961, PMCID: PMC4670727, DOI: 10.15252/msb.20156458.Peer-Reviewed Original Research
2013
Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2
Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: e2934-e2943. PMID: 23847209, PMCID: PMC3732994, DOI: 10.1073/pnas.1301985110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell DifferentiationCell MovementCell NucleusDual-Specificity PhosphatasesEnzyme ActivationGene Knockdown TechniquesGolgi ApparatusHumansIntracellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase PhosphatasesNuclear ProteinsPC12 CellsRatsConceptsPC12 cell differentiationCell migrationCell differentiationDual-specificity phosphatase familyCell fate decisionsDirectional cell migrationNuclear anchorPhosphatase familySpatiotemporal regulationGolgi polarizationSpatial regulatorCellular signalingNuclear exportERK activityGolgi apparatusERK signalingERK1/2 activationImportant regulatorInactive membersSignalingRegulatorERK1/2StyxDifferentiationDUSPs
2009
Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle
Kaimachnikov NP, Kholodenko BN. Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle. The FEBS Journal 2009, 276: 4102-4118. PMID: 19627364, PMCID: PMC2924194, DOI: 10.1111/j.1742-4658.2009.07117.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell MovementDNA ReplicationEnzyme ActivationKineticsPhosphorylationProtein ConformationSrc-Family KinasesVertebrates