2021
Can Systems Biology Advance Clinical Precision Oncology?
Rocca A, Kholodenko B. Can Systems Biology Advance Clinical Precision Oncology? Cancers 2021, 13: 6312. PMID: 34944932, PMCID: PMC8699328, DOI: 10.3390/cancers13246312.Peer-Reviewed Original ResearchSignal transduction networksSystems biology studiesGenotype-phenotype relationshipsTransduction networksSystems biology modelsSystems biologyBiological processesEnvironmental perturbationsBiology studiesCancer mutationsNetwork reconstructionPrecision oncologyBiology modelsTumor molecular alterationsBiological systemsArray of techniquesMolecular alterationsIndividual cancer patientsOncological researchBiologyValuable toolMutationsTherapeutic treatment
2007
Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space
Kholodenko B. Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space. 2007, 300-318. DOI: 10.1007/978-1-59745-531-2_16.Peer-Reviewed Original ResearchProtein phosphorylation networksReceptor tyrosine kinase signalingTrafficking of endosomesPivotal physiological processesTyrosine kinase signalingPlasma membrane receptorsPhosphorylation networksUltrasensitive switchPhosphorylated kinasesKinase signalingEnvironmental cuesCell motilitySystems biologyNegative feedback circuitPhysiological processesCellular responsesMembrane receptorsLiving cellsCellular architectureSpatiotemporal response patternsComputational approachIntricate relationshipEndosomesKinaseMitosis
2005
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
Kholodenko B, Bruggeman F, Sauro H. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks. Topics In Current Genetics 2005, 13: 143-159. DOI: 10.1007/b136809.Peer-Reviewed Original ResearchReaction-diffusion equationsCellular regulatory networksRegulatory networksSystems biologyMolecular mechanismsBiochemical networksNetwork inferencePhysiological responsesNew insightsModeling approachChemical kineticsInferenceMolecular dynamics simulationsEquationsModelingBiologyComputational modelingNetworkModular approachDynamics simulationsApproachSimulationsNovel approach