2017
Performance of objective functions and optimisation procedures for parameter estimation in system biology models
Degasperi A, Fey D, Kholodenko BN. Performance of objective functions and optimisation procedures for parameter estimation in system biology models. Npj Systems Biology And Applications 2017, 3: 20. PMID: 28804640, PMCID: PMC5548920, DOI: 10.1038/s41540-017-0023-2.Peer-Reviewed Original ResearchUnknown parametersObjective functionParameter estimationLarge dynamic modelsSpeed of convergenceMathematical modellingSystems biology modelsSimulation approachParameter spaceDynamic systemsOptimization algorithmOptimization procedureParameter estimatesNumber of directionsBiology modelsDynamic modelConvergenceReasonable amountScaling factorsSimulationsAlgorithmApproach increasesNumerous parametersEstimationParameters
2012
Understanding Cell Fate Decisions by Identifying Crucial System Dynamics
Fey D, Croucher D, Kolch W, Kholodenko B. Understanding Cell Fate Decisions by Identifying Crucial System Dynamics. SEMA SIMAI Springer Series 2012, 83-104. DOI: 10.1007/978-88-470-2571-4_5.Peer-Reviewed Original Research
1998
Mathematical modelling of superoxide generation with the bc1 complex of mitochondria
Demin O, Westerhoff H, Kholodenko B. Mathematical modelling of superoxide generation with the bc1 complex of mitochondria . Biochemistry (Moscow) 1998, 63: 634-49. PMID: 9668203.Peer-Reviewed Original ResearchMathematical modellingMathematical model