1995
Defining control coefficients in non-ideal metabolic pathways
Kholodenko B, Molenaar D, Schuster S, Heinrich R, Westerhoff H. Defining control coefficients in non-ideal metabolic pathways. Biophysical Chemistry 1995, 56: 215-226. PMID: 17023325, DOI: 10.1016/0301-4622(95)00039-z.Peer-Reviewed Original ResearchMetabolic pathwaysFlux control coefficientsHigh enzyme concentrationsMetabolic control analysisBiochemical pathwaysElemental stepsMetabolite channellingMetabolic channellingRelevant pathwaysEnzyme activityPathwayEnzymeControl coefficientsEnzyme concentrationMoiety-conserved cyclesEqual modulationsSpeciesReverse rateElemental processesModulationActivity
1994
Control theory of one enzyme
Kholodenko B, Westerhoff H. Control theory of one enzyme. Biochimica Et Biophysica Acta 1994, 1208: 294-305. PMID: 7947961, DOI: 10.1016/0167-4838(94)90116-3.Peer-Reviewed Original ResearchConceptsEnzyme catalytic cycleArbitrary kinetic schemesEnzyme catalyzed reactionsStandard free energy differenceControl of reactionsCatalytic cycleElemental stepsFree energy differenceCatalyzed reactionsFree energy dropForward rate constantElemental transitionsReaction rateEnzyme reactionRate constantsEnergy differenceEnzyme statesKinetic schemeReactionEnzyme cycleSingle enzymeEnzymeStepKineticsConstants