2002
Control Analysis for Autonomously Oscillating Biochemical Networks
Reijenga K, Westerhoff H, Kholodenko B, Snoep J. Control Analysis for Autonomously Oscillating Biochemical Networks. Biophysical Journal 2002, 82: 99-108. PMID: 11751299, PMCID: PMC1302452, DOI: 10.1016/s0006-3495(02)75377-0.Peer-Reviewed Original ResearchConceptsSummation theoremYeast glycolytic oscillationsLimit cycle oscillationsDynamic systemsControl coefficientsBiochemical networksCycle oscillationsOscillatory propertiesControl analysisMetabolic control analysisTheoremGlycolytic oscillationsTime domainOscillationsModel outputDiscrete Fourier transformFrequency domainSteady stateData setsQualitative way
1998
Thermodynamics of complexity. The live cell
Westerhoff H, Jensen P, Snoep J, Kholodenko B. Thermodynamics of complexity. The live cell. Thermochimica Acta 1998, 309: 111-120. DOI: 10.1016/s0040-6031(97)00353-5.Peer-Reviewed Original ResearchNonequilibrium thermodynamicsNear-equilibrium assumptionsNonequilibrium systemsSingle moleculesControl theoremBehavior of systemsControl coefficientsIdeal gas mixtureMetabolic control analysisIndividual moleculesMacroscopic propertiesChemical systemsThermodynamic conceptsMolecular propertiesThermodynamicsEmergent propertiesFree energyControl analysisMoleculesTheoremLiving cellsGas mixtureBiological components
1996
Control analysis of glycolytic oscillations
Bier M, Teusink B, Kholodenko B, Westerhoff H. Control analysis of glycolytic oscillations. Biophysical Chemistry 1996, 62: 15-24. PMID: 8962468, DOI: 10.1016/s0301-4622(96)02195-3.Peer-Reviewed Original ResearchMolecular Control Analysis: Control within Proteins and Molecular Processes
Brown G, Westerhoff H, Kholodenko B. Molecular Control Analysis: Control within Proteins and Molecular Processes. Journal Of Theoretical Biology 1996, 182: 389-396. PMID: 8944172, DOI: 10.1006/jtbi.1996.0178.Peer-Reviewed Original ResearchSteady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory
Cascante M, Puigjaner J, Kholodenko B. Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory. Journal Of Theoretical Biology 1996, 178: 1-6. DOI: 10.1006/jtbi.1996.0001.Peer-Reviewed Original ResearchMatrix equationBiochemical systems theorySingle matrix inversionLocal propertiesMatrix inversionSystems theoryLink matrixMetabolic control analysisControl propertiesEquationsMoiety conservationSensitivity theoryControl analysisTheoryStructural propertiesMatrixPropertiesState characterizationInversion
1994
How to determine control of growth rate in a chemostat. Using metabolic control analysis to resolve the paradox.
Snoep J, Jensen P, Groeneveld P, Molenaar D, Kholodenko B, Westerhoff H. How to determine control of growth rate in a chemostat. Using metabolic control analysis to resolve the paradox. IUBMB Life 1994, 33: 1023-32. PMID: 7987249.Peer-Reviewed Original ResearchGetting to the inside of cells using metabolic control analysis
Westerhoff H, Hofmeyr J, Kholodenko B. Getting to the inside of cells using metabolic control analysis. Biophysical Chemistry 1994, 50: 273-283. PMID: 8011948, DOI: 10.1016/0301-4622(93)e0095-m.Peer-Reviewed Original ResearchConceptsKinetic propertiesIsolated statePropertiesConcentration control coefficientsControl analysis
1993
The sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two
van DAM K, van der VLAG J, KHOLODENKO B, WESTERHOFF H. The sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two. The FEBS Journal 1993, 212: 791-799. PMID: 8462550, DOI: 10.1111/j.1432-1033.1993.tb17720.x.Peer-Reviewed Original ResearchConceptsGroup-transfer pathwaysReaction activityDissociation rate constantsElectron transfer chainAcceptor couplesEnzyme-enzyme interactionsEnzyme concentrationRate constantsEnzyme-enzyme complexEnzyme interactionsComplexesControl of enzymesEnzyme complexEnzymeConcentrationBacterial phosphoenolpyruvateMain pathwayInteractionConstantsChainControl analysisSimple metabolic pathwaysSugar phosphotransferase system