2005
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
Kholodenko B, Bruggeman F, Sauro H. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks. Topics In Current Genetics 2005, 13: 143-159. DOI: 10.1007/b136809.Peer-Reviewed Original ResearchReaction-diffusion equationsCellular regulatory networksRegulatory networksSystems biologyMolecular mechanismsBiochemical networksNetwork inferencePhysiological responsesNew insightsModeling approachChemical kineticsInferenceMolecular dynamics simulationsEquationsModelingBiologyComputational modelingNetworkModular approachDynamics simulationsApproachSimulationsNovel approach
2002
Modular Interaction Strengths in Regulatory Networks; An Example
Bruggeman F, Kholodenko B. Modular Interaction Strengths in Regulatory Networks; An Example. Molecular Biology Reports 2002, 29: 57-61. PMID: 12241075, DOI: 10.1023/a:1020354302260.Peer-Reviewed Original ResearchControl Analysis for Autonomously Oscillating Biochemical Networks
Reijenga K, Westerhoff H, Kholodenko B, Snoep J. Control Analysis for Autonomously Oscillating Biochemical Networks. Biophysical Journal 2002, 82: 99-108. PMID: 11751299, PMCID: PMC1302452, DOI: 10.1016/s0006-3495(02)75377-0.Peer-Reviewed Original ResearchConceptsSummation theoremYeast glycolytic oscillationsLimit cycle oscillationsDynamic systemsControl coefficientsBiochemical networksCycle oscillationsOscillatory propertiesControl analysisMetabolic control analysisTheoremGlycolytic oscillationsTime domainOscillationsModel outputDiscrete Fourier transformFrequency domainSteady stateData setsQualitative way