2022
Deciphering Spatial Protein–Protein Interactions in Brain Using Proximity Labeling
Mathew B, Bathla S, Williams KR, Nairn AC. Deciphering Spatial Protein–Protein Interactions in Brain Using Proximity Labeling. Molecular & Cellular Proteomics 2022, 21: 100422. PMID: 36198386, PMCID: PMC9650050, DOI: 10.1016/j.mcpro.2022.100422.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsProximity labelingBiological functionsComplex protein-protein interactionsProximity labeling methodProtein-DNA interactionsCell-cell communicationMost biological functionsDistinct cell typesProtein-RNANerve cell functionCell typesBiomolecular complexesCellular levelPhysical interactionProteomeCell functionSpecific subsetProteinSynaptic plasticityComplete catalogLabeling methodRecent advancesPowerful toolAxonal projections
2021
Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective
Mathew B, Mansuri MS, Williams KR, Nairn AC. Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective. Brain Sciences 2021, 11: 258. PMID: 33669482, PMCID: PMC7922222, DOI: 10.3390/brainsci11020258.Peer-Reviewed Original ResearchProtein dynamic rangeDifferent cell typesProteomic perspectiveRNA speciesExosome proteomicsDisease biomarker discoveryIsolation of exosomesProteomics researchCell typesPhysiological statusExosomesCell of originNovel reservoirVariable tissueBiomarker discoveryProteinProtein detectionProtein biomarkersCurrent progressProteomicsBiomarker toolSpeciesLow amountsRapid rateNeuropsychiatric disorders