1995
Nonlinear sequence-dependent structure of nigral dopamine neuron interspike interval firing patterns
Hoffman R, Shi W, Bunney B. Nonlinear sequence-dependent structure of nigral dopamine neuron interspike interval firing patterns. Biophysical Journal 1995, 69: 128-137. PMID: 7669889, PMCID: PMC1236231, DOI: 10.1016/s0006-3495(95)79882-4.Peer-Reviewed Original ResearchConceptsNonlinear deterministic structureDeterministic structureNumber of degreesDopamine neuronsDynamical analysisEffect of nonstationarityRandom processFiring patternsNigral dopamine neuronsRat substantia nigraSubstantia nigraSynaptic inputsISI sequencesNeuron responsesTime seriesNeural circuit interactionsSequence-dependent structureNeuronsFiring modesCircuit interactionsOverall predictabilityNonstationarity
1988
Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells
Yeomans J, Maidment N, Bunney B. Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells. Brain Research 1988, 450: 86-93. PMID: 3261193, DOI: 10.1016/0006-8993(88)91547-8.Peer-Reviewed Original Research
1985
Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsDA cellsStriatal stimulationReticulata neuronsDA neuronsRebound depolarizationReversal potentialSubstantia nigra zona reticulata neuronsStriatonigral GABAergic pathwayMidbrain dopamine cell activityDopamine cell activitySame stimulation parametersChloride injectionChloride channel blockerChloride reversal potentialSimilar reversal potentialsSimilar time courseGABAergic pathwayGABAergic projectionsZona reticulataPostsynaptic potentialsSystemic injectionChannel blockersIntracellular recordingsStriatal cells
1984
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopamineEgtazic AcidElectric StimulationGlutamatesGlutamic AcidIontophoresisMaleNeuronsRatsRats, Inbred StrainsSubstantia NigraConceptsSingle-spike firingDA cellsSlow depolarizationCalcium chelator EGTADopamine neuronsSpike firingCalcium-activated potassium conductanceActive DA cellsNigral dopamine neuronsChelator EGTAVivo intracellular recordingsDA neuronsDepolarization inactivationMembrane potentialIontophoretic applicationTrain of spikesIntracellular recordingsExcitatory substancesIntracellular injectionCalcium entryAction potentialsAfterhyperpolarizationPotassium conductanceRate of riseNeurons
1980
Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
Hommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDopamineElectric StimulationHaloperidolMaleNeural PathwaysNeuronsRatsSciatic NerveSensationSubstantia NigraConceptsStriato-nigral pathwayDopaminergic neuronsReticulata neuronsInhibitory periodSingle-unit recording techniquesNon-dopaminergic neuronsNigro-striatal pathwaySciatic nerve stimulationRat substantia nigraDopaminergic neuron activitySensory stimuliInitial inhibitionStimulation-induced changesActivity of dopaminergicNigral neuronsNerve stimulationSubstantia nigraNeuron activityNeuronsRecording techniquesHaloperidolLesionsInhibitionStimulationPathway
1975
Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics.
Bunney B, Roth R, Aghajanian G. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications 1975, 1: 349-58. PMID: 1224004.Peer-Reviewed Original ResearchConceptsEffects of molindoneCentral dopaminergic neuronal activityExtracellular single-unit recordingsLow intravenous dosesDopaminergic neuronal activityDA neuron activityMost antipsychotic drugsBaseline firing rateSingle-unit recordingsDA metabolismDA neuronsIntravenous dosesClassical neurolepticsDopaminergic neuronsOlfactory tubercleDA cellsAntipsychotic drugsD-amphetamineInduced depressionRat midbrainDopamine synthesisNeuronal activityUnit recordingsNeuron activityMolindone