1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta