1984
Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons
Chiodo L, Bannon M, Grace A, Roth R, Bunney B. Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 1984, 12: 1-16. PMID: 6462443, DOI: 10.1016/0306-4522(84)90133-7.Peer-Reviewed Original ResearchConceptsSpikes/sDopamine neuronsPiriform cortexDopamine levelsCaudate nucleusCingulate cortexIntravenous administrationDopamine cellsFiring rateGlyoxylic acid-induced histofluorescenceCatecholamine histofluorescence techniquesMesocortical dopamine neuronsNerve terminal autoreceptorsNigrostriatal dopamine cellsDose-dependent inhibitory responseDopamine agonist apomorphineBasal discharge rateMidbrain dopaminergic neuronsMidbrain dopaminergic systemMean firing rateMidbrain dopamine systemMesocortical neuronsAgonist apomorphineMicroiontophoretic applicationAntidromic activation
1983
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates
Grace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates. Neuroscience 1983, 10: 317-331. PMID: 6633864, DOI: 10.1016/0306-4522(83)90136-7.Peer-Reviewed Original ResearchConceptsInitial segment spikesDopamine neuronsSlow depolarizationAction potentialsAxon hillockDendritic dopamine releaseLong-duration afterhyperpolarizationNigral dopamine neuronsLow-threshold spikesLucifer yellow injectionExtracellular recording techniquesLong-duration spikesAction potential generationDopaminergic neuronsSpecific ionic currentsIntracellular recordingsDopamine releaseIntracellular injectionElectrophysiological studiesDendritic spikesMajor dendritesNeuron 2Action potential generating mechanismSomatic regionNeuronal compartments
1982
A modification of the rapid glyoxylic acid technique permits visualization of serotonergic and hypothalamic dopaminergic neurons
Rassmussen S, Bunney B. A modification of the rapid glyoxylic acid technique permits visualization of serotonergic and hypothalamic dopaminergic neurons. Journal Of Neuroscience Methods 1982, 6: 139-144. PMID: 6750255, DOI: 10.1016/0165-0270(82)90024-3.Peer-Reviewed Original ResearchConceptsGlyoxylic acid techniqueHypothalamic dopaminergic neuronsTryptophan hydroxylase inhibitorHypothalamic cell groupsTryptophan pretreatmentCatecholaminergic neuronsDopaminergic neuronsHypothalamic neuronsPara-chlorophenylalanineDendritic fieldsSerotonergic systemCatecholamine systemsColchicine administrationHydroxylase inhibitorColchicine pretreatmentCell groupsNeuronsAcid techniqueMethod of choiceReliable visualizationPretreatmentDopaminergicHistofluorescenceImmunocytohistochemistryAdministration
1979
Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDoses