1986
Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons
1985
Firing properties of substantia nigra dopaminergic neurons in freely moving rats
Freeman A, Meltzer L, Bunney B. Firing properties of substantia nigra dopaminergic neurons in freely moving rats. Life Sciences 1985, 36: 1983-1994. PMID: 3990520, DOI: 10.1016/0024-3205(85)90448-5.Peer-Reviewed Original ResearchConceptsPutative DA neuronsDA neuronsDopaminergic neuronsParalyzed ratsSubstantia nigra dopaminergic neuronsFiring patternsPutative dopaminergic neuronsNigrostriatal DA systemNigra dopaminergic neuronsApomorphine-induced inhibitionSingle spike activityPattern of firingSingle-unit recordingsDegree of burstSubstantia nigraDA cellsElectrophysiological characteristicsUnit recordingsSpike activityFiring propertiesRatsFiring rateNeuronsDA systemCells