1988
Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration
1985
Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiologyOpposing effects of striatonigral feedback pathways on midbrain dopamine cell activity
Grace A, Bunney B. Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Research 1985, 333: 271-284. PMID: 2986775, DOI: 10.1016/0006-8993(85)91581-1.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsDA cellsStriatal stimulationReticulata neuronsDA neuronsRebound depolarizationReversal potentialSubstantia nigra zona reticulata neuronsStriatonigral GABAergic pathwayMidbrain dopamine cell activityDopamine cell activitySame stimulation parametersChloride injectionChloride channel blockerChloride reversal potentialSimilar reversal potentialsSimilar time courseGABAergic pathwayGABAergic projectionsZona reticulataPostsynaptic potentialsSystemic injectionChannel blockersIntracellular recordingsStriatal cells