2000
Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil
Zhang X, Bunney B, Shi W. Enhancement of NMDA‐induced current by the putative NR2B selective antagonist ifenprodil. Synapse 2000, 37: 56-63. PMID: 10842351, DOI: 10.1002/(sici)1098-2396(200007)37:1<56::aid-syn6>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAnimalsDizocilpine MaleateDose-Response Relationship, DrugDrug SynergismElectrophysiologyExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGlycineKynurenic AcidMaleMembrane PotentialsN-MethylaspartateOrgan Culture TechniquesPiperidinesPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSpermineConceptsLow NMDA concentrationsNMDA currentsNMDA concentrationReceptor affinityNMDA receptor affinityEffects of ifenprodilNR2B-selective antagonist ifenprodilEnhancement of NMDARat brain slicesNMDA receptorsAntagonist selectiveBrain slicesSubcortical areasNR2B subunitNMDANoncompetitive antagonistIfenprodilCGP37849Same concentrationKynurenatePrevious studiesAntagonistReceptors
1997
Characterization of dopamine‐induced depolarization of prefrontal cortical neurons
Shi W, Zheng P, Liang X, Bunney B. Characterization of dopamine‐induced depolarization of prefrontal cortical neurons. Synapse 1997, 26: 415-422. PMID: 9215600, DOI: 10.1002/(sici)1098-2396(199708)26:4<415::aid-syn9>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsEffects of dopaminePFC neuronsDA agonistsPrefrontal cortexAtypical antipsychotic drug clozapinePrefrontal cortical neuronsRat brain slicesAntipsychotic drug clozapineWhole-cell recordingsPFC pyramidal cellsSynaptic blockadeDA receptorsBeta antagonistDA antagonistsSubstantia nigraCortical neuronsPyramidal cellsBrain slicesDrug clozapineCell recordingsNeuronsAntagonistNonspecific mechanismsDopamineDepolarization