1985
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
Chiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.Peer-Reviewed Original ResearchConceptsDA neuronsClozapine administrationChronic treatmentDepolarization inactivationExtracellular single cell recording techniquesInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidVentral tegmental area (VTA) dopamineSingle cell recording techniquesA10 DA neuronsVivo spontaneous activityMidbrain DA neuronsChloral hydrate anesthesiaCombination of drugsMidbrain dopamine neuronsGamma-aminobutyric acidDifferential effectsMechanism of actionAcute treatmentMicroiontophoretic applicationSubstantia nigraReceptor antagonistDA cellsDopamine neuronsSpontaneous activity
1983
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.Peer-Reviewed Original ResearchConceptsExtrapyramidal side effectsDepolarization inactivationA10 neuronsAntipsychotic drugsDA neuronsDopaminergic neuronsSide effectsExtracellular single-unit recording techniquesExcitatory amino acid glutamateInhibitory neurotransmitter gamma-aminobutyric acidSingle-unit recording techniquesNeurotransmitter gamma-aminobutyric acidActive DA cellsA10 dopaminergic neuronsMidbrain dopaminergic neuronsGamma-aminobutyric acidActivity of A9Amino acid glutamateChronic administrationMicroiontophoretic applicationNeuroleptic treatmentNeuroleptic administrationAtypical neurolepticsTricyclic antidepressantsDA cells