1990
Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study
Moghaddam B, Bunney B. Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study. Journal Of Neurochemistry 1990, 54: 1755-1760. PMID: 1969939, DOI: 10.1111/j.1471-4159.1990.tb01230.x.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexOutflow of dopamineRelease of dopamineNucleus accumbensAntipsychotic drugsPrefrontal cortexAcute effectsExtracellular levelsAtypical antipsychotic drug clozapineVivo microdialysis studyAtypical antipsychotic drugsEffects of sulpirideEffects of haloperidolAntipsychotic drug clozapineMicrodialysis studyVivo microdialysisDrug clozapineHaloperidolStriatumAccumbensCortexSulpirideExtracellular concentrationDopamineDrugsUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol
1986
Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons
1980
Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
Hommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.Peer-Reviewed Original ResearchConceptsStriato-nigral pathwayDopaminergic neuronsReticulata neuronsInhibitory periodSingle-unit recording techniquesNon-dopaminergic neuronsNigro-striatal pathwaySciatic nerve stimulationRat substantia nigraDopaminergic neuron activitySensory stimuliInitial inhibitionStimulation-induced changesActivity of dopaminergicNigral neuronsNerve stimulationSubstantia nigraNeuron activityNeuronsRecording techniquesHaloperidolLesionsInhibitionStimulationPathwayPeripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons
Grace A, Hommer D, Bunney B. Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons. Brain Research Bulletin 1980, 5: 105-109. DOI: 10.1016/0361-9230(80)90017-9.Peer-Reviewed Original ResearchDA cellsZona reticulataGABA agonistsInhibitory influenceDA cell firing rateDopamine receptor blocker haloperidolStriato-nigral pathwayNigral dopamine cellsCell firing rateReticulata neuronsStriatal influencesSubstantia nigraDopaminergic cellsDopamine cellsNoxious stimuliLow dosesFiring rateNeuronsInhibitory effectAgonistsCell rateCellsHaloperidolMuscimolDoses
1979
The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
Skirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.Peer-Reviewed Original ResearchConceptsCaudate nucleusIontophoretic dopamineChronic HAL treatmentChronic haloperidol treatmentDifferent treatment regimensEffects of haloperidolDays of treatmentType IDrug terminationPostsynaptic supersensitivityHaloperidol treatmentTardive dyskinesiaTreatment regimensDaily dosesHAL treatmentSingle doseSpontaneous activitySupersensitive responseTreatment groupsType I unitsHaloperidolType II unitsInhibitory effectDopamineActive type I