1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1987
Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin
Freeman A, Bunney B. Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin. Brain Research 1987, 405: 46-55. PMID: 3032350, DOI: 10.1016/0006-8993(87)90988-7.Peer-Reviewed Original ResearchConceptsCCK-8A9 neuronsDA neuronsDopaminergic neuronsUnrestrained ratsVentral tegmental area cellsFiring rateCCK-8 pretreatmentDA cell activitySingle dopaminergic neuronsEffects of apomorphineA10 dopaminergic neuronsActivity of A9Sulfated CCK-8A10 neuronsDA agonistsAnesthetized ratsParalyzed ratsSequential dosesA10 cellsCell activityCell firingUnit firingUnit activityApomorphine
1985
Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiology
1979
Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDoses
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta