1987
Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences
Chiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.Peer-Reviewed Original ResearchConceptsDepolarization-induced inactivationFiring rateDopaminergic neuronsDopamine receptor agonist apomorphineMonths' continuous treatmentAcute oral administrationBasal firing rateActive DA neuronsReceptor agonist apomorphineA10 dopaminergic neuronsActive dopamine neuronsClassical antipsychotic drugsDopamine-containing neuronsPresence of haloperidolHr of administrationLong-term treatmentMidbrain dopaminergic neuronsCholecystokinin receptor antagonistAge-matched controlsHaloperidol resultsA10 regionDA neuronsAcute administrationAgonist apomorphineNeuroleptic haloperidol
1986
Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.
Grace A, Bunney B. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording. Journal Of Pharmacology And Experimental Therapeutics 1986, 238: 1092-100. PMID: 3746660.Peer-Reviewed Original ResearchConceptsAdministration of haloperidolDopamine neuronsVivo intracellular recordingsDepolarization blockIntracellular recordingsNigral dopamine neuronsAdministration of neurolepticsActive dopamine neuronsSpontaneous spike activityDopamine agonist apomorphineAntipsychotic drug haloperidolSpontaneous electrophysiological activityMidbrain dopamine neuronsAcute administrationAgonist apomorphineSubstantia nigraControl ratsExcitatory driveDepolarization blockadeDrug haloperidolSpontaneous activitySpike activityFiring rateHaloperidolNeurons