2019
Higher Inpatient Mortality for Women after Intervention for Lifestyle Limiting Claudication
Miller SM, Sumpio BJ, Miller MS, Erben Y, Cordova AC, Sumpio BE. Higher Inpatient Mortality for Women after Intervention for Lifestyle Limiting Claudication. Annals Of Vascular Surgery 2019, 58: 54-62. PMID: 30910650, DOI: 10.1016/j.avsg.2019.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedComorbidityCritical IllnessDatabases, FactualEndovascular ProceduresFemaleHealth Status DisparitiesHospital MortalityHumansIntermittent ClaudicationIschemiaMalePatient AdmissionPeripheral Arterial DiseaseRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsLifestyle-limiting claudicationHigher inpatient mortalityCritical limb ischemiaPeripheral artery diseaseInpatient mortalitySex-related differencesVascular interventionsEV interventionsArtery diseaseChronic obstructive pulmonary diseaseRegression analysisChronic renal failureObstructive pulmonary diseaseOpen surgical repairCoronary artery diseaseNationwide Inpatient SampleLogistic regression analysisChi-squared testLimb ischemiaRenal failureIndependent predictorsOpen repairPulmonary diseaseSurgical repairTreatment guidelines
2018
Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds
Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/circimaging.117.006932.Peer-Reviewed Original ResearchMeSH KeywordsAnkle Brachial IndexCase-Control StudiesCritical IllnessDiabetic FootHumansIschemiaMicrocirculationOrganophosphorus CompoundsOrganotechnetium CompoundsPerfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRegional Blood FlowSingle Photon Emission Computed Tomography Computed TomographyWound HealingConceptsCritical limb ischemiaAnkle-brachial indexStandardized uptake valueSPECT/CT imagingDiabetic patientsHealthy subjectsSPECT/CTFoot perfusionUptake valueLimb ischemiaMicrovascular perfusionSkeletal muscle microvascular perfusionCT imagingDiabetic CLI patientsMuscle microvascular perfusionPeripheral artery diseaseSingle photon emissionIntraclass correlation coefficientAngiosome perfusionCLI subjectsCLI patientsArtery diseaseDiabetes mellitusCT perfusionVascular territoriesAcute Limb Ischemia in an 8-Year-Old Patient: A Case Report
Erben Y, Miller SM, Sumpio BJ, Dillon BJ, Lee AI, Blume P, Sumpio BE, Mena-Hurtado C. Acute Limb Ischemia in an 8-Year-Old Patient: A Case Report. Annals Of Vascular Surgery 2018, 51: 327.e1-327.e8. PMID: 29655809, DOI: 10.1016/j.avsg.2018.02.012.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexNormal ankle-brachial indexRight foot painAcute limb ischemiaLower extremity angiographyLeg length discrepancyFoot insertsIntermittent painIntravenous heparinFoot painLimb ischemiaOlder patientsNephrotic syndromeEmergency departmentPhysical examinationCapillary refillCase reportLength discrepancyLeft footPatient's motherPatientsPainMothersFootFasciotomy
2017
Distal embolization during lower extremity endovascular interventions
Chaar C, Shebl F, Sumpio B, Dardik A, Indes J, Sarac T. Distal embolization during lower extremity endovascular interventions. Journal Of Vascular Surgery 2017, 66: 143-150. PMID: 28366300, DOI: 10.1016/j.jvs.2017.01.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalAngioplasty, BalloonAtherectomyChi-Square DistributionCritical IllnessDatabases, FactualDisease-Free SurvivalEmbolismFemaleFemoral ArteryHumansIncidenceIntermittent ClaudicationIschemiaLimb SalvageLower ExtremityMaleMiddle AgedMultivariate AnalysisNew EnglandOdds RatioPeripheral Arterial DiseaseProportional Hazards ModelsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeVascular PatencyConceptsLower extremity endovascular interventionsSuperficial femoral arteryCritical limb ischemiaDistal embolizationLoss of patencyEndovascular interventionBalloon angioplastyLimb ischemiaAdditional endovascular interventionArterial endovascular interventionUse of atherectomyVascular Study GroupLength of occlusionNew England databaseNumber of arteriesMajor amputationMost patientsPatient characteristicsFemoral arteryRisk factorsStudy groupMultivariable regressionLimb lossLower riskAngioplasty
2015
Consequences of hypogastric artery ligation, embolization, or coverage
Chitragari G, Schlosser FJ, Chaar C, Sumpio BE. Consequences of hypogastric artery ligation, embolization, or coverage. Journal Of Vascular Surgery 2015, 62: 1340-1347.e1. PMID: 26386508, DOI: 10.1016/j.jvs.2015.08.053.Peer-Reviewed Original ResearchConceptsVascular surgery patientsHypogastric arteryIschemic complicationsVascular surgeryProximal interruptionSurgery patientsComplication rateMedian ageOncology patientsRisk factorsSignificant differencesHypogastric artery ligationIschemic complication rateDevelopment of complicationsSpinal cord ischemiaData of patientsClear risk factorsButtock claudicationButtock necrosisColonic ischemiaCord ischemiaBilateral embolizationDistal embolizationProximal embolizationControlled Trials
2014
A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model
Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Muhs BE, Sumpio BE. A comparison of open and endovascular revascularization for chronic mesenteric ischemia in a clinical decision model. Journal Of Vascular Surgery 2014, 60: 715-725.e2. PMID: 24721175, DOI: 10.1016/j.jvs.2014.03.009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overComparative Effectiveness ResearchComputer SimulationCost-Benefit AnalysisDecision Support TechniquesEndovascular ProceduresFemaleHealth Care CostsHumansIschemiaMaleMarkov ChainsMesenteric IschemiaMiddle AgedPatient SelectionPredictive Value of TestsQuality of LifeQuality-Adjusted Life YearsReoperationRisk AssessmentRisk FactorsSex FactorsTime FactorsTreatment OutcomeVascular DiseasesVascular PatencyVascular Surgical ProceduresConceptsChronic mesenteric ischemiaIncremental cost-effectiveness ratioEndovascular revascularizationCost-effectiveness ratioMesenteric ischemiaFemale patientsMortality riskAge groupsGood short-term resultsDisease-specific mortality riskPatients 60 yearsOverall mortality riskMarkov state transition modelTreatment of choiceExpensive treatment strategiesShort-term resultsHealth care perspectiveHealth care costsDifferent clinical scenariosProbabilistic sensitivity analysesClinical decision modelDecision analysis modelOlder patientsConservative managementYounger patientsContemporary assessment of foot perfusion in patients with critical limb ischemia
Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaFoot perfusionLower extremity perfusionPeripheral arterial diseaseTranscutaneous oxygen monitoringRevascularization techniquesArterial diseaseFoot ulcerationLimb salvageRevascularization therapyFluorescent angiographyPatient outcomesEndovascular proceduresDisease processPatient careIschemiaDiagnostic imagingPatientsPerfusionImaging modalitiesLaser DopplerOxygen monitoringPlanning interventionsModalities
2012
Lower extremity limb salvage with cryoplasty: a single-center cohort study
Basco MT, Schlösser FJ, Muhs BE, Indes JE, Blume PA, Key JJ, Aruny JE, Sumpio BE. Lower extremity limb salvage with cryoplasty: a single-center cohort study. Vascular 2012, 20: 36-41. PMID: 22328618, DOI: 10.1258/vasc.2011.oa0309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmputation, SurgicalChi-Square DistributionConnecticutCryosurgeryFemaleHumansIschemiaKaplan-Meier EstimateLimb SalvageLower ExtremityMaleMiddle AgedPatient SelectionPeripheral Arterial DiseaseRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsChronic critical limb ischemiaCritical limb ischemiaCohort studyLimb ischemiaArtery diseaseSalvage rateSingle-center cohort studyRetrospective cohort studyLimb salvage ratePeripheral artery diseaseHistory of smokingLower extremity revascularizationCoronary artery diseaseKaplan-Meier analysisTechnical success rateLower extremity limb salvagePoor wound healingLower extremity lesionsRecent clinical experienceInadequate conduitMajor amputationPersistent ulcerationRest painSurgical revascularizationUncontrolled hypertension
2003
Vascular evaluation and arterial reconstruction of the diabetic foot
Sumpio BE, Lee T, Blume PA. Vascular evaluation and arterial reconstruction of the diabetic foot. Clinics In Podiatric Medicine And Surgery 2003, 20: 689-708. PMID: 14636033, DOI: 10.1016/s0891-8422(03)00088-0.Peer-Reviewed Original ResearchMeSH KeywordsArteriesDiabetic FootFootHumansIschemiaPhysical ExaminationVascular Surgical ProceduresConceptsInfected footDiabetic footLimb salvageNon-invasive vascular studiesCardiovascular risk factor managementAggressive multidisciplinary approachAggressive surgical drainagePalpable pedal pulsesLimb-threatening ischemiaPeripheral vascular diseaseRisk factor managementLower extremity revascularizationStandard clinical evaluationPrimary care providersCumulative limb salvageEvidence of infectionHigh-risk groupBlood glucose controlHigh-risk populationComplex clinical problemAbsent pulsesAggressive drainageIschemic ulcerationPedal bypassPedal pulses
2000
Foot Ulcers
Sumpio BE. Foot Ulcers. New England Journal Of Medicine 2000, 343: 787-793. PMID: 10984568, DOI: 10.1056/nejm200009143431107.Peer-Reviewed Original ResearchConceptsPrimary care physiciansComprehensive treatment protocolMajor amputationPedal woundsAggressive treatmentFoot complicationsCare physiciansFoot ulcersVascular diseaseEarly recognitionRisk factorsPatient educationBiomechanical abnormalitiesTreatment protocolPrevents infectionOptimal managementSkin integrityCareful assessmentMultidisciplinary approachInfectionUlcerationComplicationsUlcersAmputationManagement
1999
Clinical and Biological Relevance of Vein Cuff Anastomosis
Steinthorsson G, Sumpio B. Clinical and Biological Relevance of Vein Cuff Anastomosis. Acta Chirurgica Belgica 1999, 99: 282-288. PMID: 10674129, DOI: 10.1080/00015458.1999.12098497.Peer-Reviewed Original ResearchConceptsSuitable autologous saphenous veinAutologous saphenous veinAlternative graft materialGraft failureDistal anastomosisCuff anastomosisPTFE graftsFemorodistal bypassSaphenous veinImproved patencyPoor patencyVenous cuffKnee positionPatencyGraft materialProsthetic materialAnastomosisGraftPossible mechanical explanationBiological basisSignificant numberSeries of studiesPatientsBypassCuff
1997
Mesenteric ischemia secondary to cocaine abuse: case reports and literature review.
Sudhakar CB, Al-Hakeem M, MacArthur JD, Sumpio BE. Mesenteric ischemia secondary to cocaine abuse: case reports and literature review. The American Journal Of Gastroenterology 1997, 92: 1053-4. PMID: 9177533.Peer-Reviewed Original Research
1993
Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion
McMillen M, Huribal M, Sumpio B. Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusion. The American Journal Of Surgery 1993, 166: 557-562. PMID: 8238752, DOI: 10.1016/s0002-9610(05)81153-5.Peer-Reviewed Original ResearchConceptsBlood flowVascular endotheliumSignificant organ dysfunctionImpaired blood flowEndothelial-leukocyte interactionsRestoration of functionOrgan dysfunctionReperfusion injuryInflammatory cellsIschemia resultsInflammatory responseLeukocyte adherenceFurther injuryNeutrophil interactionsOxygen deliveryCurrent evidenceCellular injuryIschemiaEndothelial cellsInjuryCommon pathwayEndotheliumCurrent literatureCellular functionsAnaerobic mechanismsLipoprotein (a): A Risk Factor for Peripheral Vascular Disease
Widmann M, Sumpio B. Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease. Annals Of Vascular Surgery 1993, 7: 446-451. PMID: 8268090, DOI: 10.1007/bf02002128.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseCoronary artery diseaseDiabetes mellitusCigarette smokingRisk factorsCerebrovascular atherosclerotic diseaseWhite male patientArtery diseaseMale patientsAtherosclerotic diseasePlasma levelsVascular diseasePatientsDiseaseSerum proteinsMellitusComplicationsSmokingLipoprotein
1987
Aortic thrombosis with paraplegia: an unusual consequence of blunt abdominal trauma.
Sumpio B, Gusberg R. Aortic thrombosis with paraplegia: an unusual consequence of blunt abdominal trauma. Journal Of Vascular Surgery 1987, 6: 412-4. PMID: 3309383, DOI: 10.1067/mva.1987.avs0060412.Peer-Reviewed Original ResearchAortic thrombosis with paraplegia: An unusual consequence of blunt abdominal trauma
Sumpio B, Gusberg R. Aortic thrombosis with paraplegia: An unusual consequence of blunt abdominal trauma. Journal Of Vascular Surgery 1987, 6: 412-414. DOI: 10.1016/0741-5214(87)90015-2.Peer-Reviewed Original ResearchComparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia
Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. American Journal Of Physiology 1987, 252: r388-r393. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.r388.Peer-Reviewed Original ResearchConceptsRenal functionATP-MgCl2Warm ischemiaATP-MgCl2 treatmentKrebs-HCO3 bufferMM ATP-MgCl2Comparison of effectsNormothermic ischemiaTransient improvementIschemiaSalutary effectsControl valuesUrine samplesFunctional parametersKidneyMajor breakdown productAdenosineTreatmentBreakdown productsMmHgPerfusateMinAdministration
1985
Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance
Sumpio B, Chaudry I, Baue A. Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance. JAMA Surgery 1985, 120: 233-240. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.Peer-Reviewed Original ResearchConceptsIntracellular acidosisPerfusate flowATP levelsAdenosine triphosphate-magnesium chlorideRenal ATP levelsMinutes of reperfusionTissue ATP levelsEffects of ischemiaAdenosine triphosphateML/minPostischemic administrationReperfusion injuryRenal ischemiaWarm ischemiaATP-MgCl2ReperfusionIschemiaInorganic phosphate peakIntracellular adenosine triphosphatePi peakRat kidneyAcidosisATP depletionMinutesMagnetic resonance
1984
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. American Journal Of Physiology 1984, 247: r1047-r1053. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.r1047.Peer-Reviewed Original ResearchConceptsRenal perfusate flow rateMM ATP-MgCl2Min of perfusionIsolated rat kidneyATP-MgCl2Renal functionWarm ischemiaWhole kidney inulin clearanceRat kidneyAccelerated functional recoveryMin of reperfusionMin of ischemiaUrine flow rateTissue ATP levelsFractional absorptionFunctional recoveryNormothermic ischemiaIschemia resultsMin ischemiaPerfusate flow rateInulin clearanceEarly recoverySystemic effectsIschemiaSodium values