2018
Regulation of Yes-Associated Protein by Laminar Flow
Chitragari G, Shalaby SY, Sumpio BJ, Kurita J, Sumpio BE. Regulation of Yes-Associated Protein by Laminar Flow. Annals Of Vascular Surgery 2018, 52: 183-191. PMID: 29758328, DOI: 10.1016/j.avsg.2018.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingCell ShapeCells, CulturedCytoskeletonDown-RegulationHuman Umbilical Vein Endothelial CellsHumansMechanotransduction, CellularPhosphoproteinsPhosphorylationProteolysisPulsatile FlowRegional Blood FlowStress, MechanicalTime FactorsTranscription FactorsYAP-Signaling ProteinsConceptsHuman umbilical vein endothelial cellsTotal YAPExposure of HUVECsRelease of mediatorsYAP levelsSignificant decreaseUbiquitin-proteasome system inhibitorsUmbilical vein endothelial cellsEndothelial cell proliferationVein endothelial cellsVascular healthSystem inhibitorsYes-Associated ProteinDisease modulationIntimal hyperplasiaDisturbed flowEndothelial cellsBlood vesselsDisease statesPotential targetCell proliferationProteasome-independent mechanismExposureKey regulatorPYAPRadiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds
Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/circimaging.117.006932.Peer-Reviewed Original ResearchMeSH KeywordsAnkle Brachial IndexCase-Control StudiesCritical IllnessDiabetic FootHumansIschemiaMicrocirculationOrganophosphorus CompoundsOrganotechnetium CompoundsPerfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRegional Blood FlowSingle Photon Emission Computed Tomography Computed TomographyWound HealingConceptsCritical limb ischemiaAnkle-brachial indexStandardized uptake valueSPECT/CT imagingDiabetic patientsHealthy subjectsSPECT/CTFoot perfusionUptake valueLimb ischemiaMicrovascular perfusionSkeletal muscle microvascular perfusionCT imagingDiabetic CLI patientsMuscle microvascular perfusionPeripheral artery diseaseSingle photon emissionIntraclass correlation coefficientAngiosome perfusionCLI subjectsCLI patientsArtery diseaseDiabetes mellitusCT perfusionVascular territories
2015
Consequences of hypogastric artery ligation, embolization, or coverage
Chitragari G, Schlosser FJ, Chaar C, Sumpio BE. Consequences of hypogastric artery ligation, embolization, or coverage. Journal Of Vascular Surgery 2015, 62: 1340-1347.e1. PMID: 26386508, DOI: 10.1016/j.jvs.2015.08.053.Peer-Reviewed Original ResearchConceptsVascular surgery patientsHypogastric arteryIschemic complicationsVascular surgeryProximal interruptionSurgery patientsComplication rateMedian ageOncology patientsRisk factorsSignificant differencesHypogastric artery ligationIschemic complication rateDevelopment of complicationsSpinal cord ischemiaData of patientsClear risk factorsButtock claudicationButtock necrosisColonic ischemiaCord ischemiaBilateral embolizationDistal embolizationProximal embolizationControlled Trials
2014
Contemporary assessment of foot perfusion in patients with critical limb ischemia
Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaFoot perfusionLower extremity perfusionPeripheral arterial diseaseTranscutaneous oxygen monitoringRevascularization techniquesArterial diseaseFoot ulcerationLimb salvageRevascularization therapyFluorescent angiographyPatient outcomesEndovascular proceduresDisease processPatient careIschemiaDiagnostic imagingPatientsPerfusionImaging modalitiesLaser DopplerOxygen monitoringPlanning interventionsModalities
2013
Clinical implications of the angiosome model in peripheral vascular disease
Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-826. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseVascular diseaseAngiosome modelVascular surgeryCritical limb ischemiaLarger patient populationReperfusion strategyProspective trialRevascularization attemptsSuccessful revascularizationLimb ischemiaSecondary amputationProspective studyFluorescent angiographyPatient populationVascular operationsAngiosome conceptEndovascular proceduresUnhealed woundsSystematic reviewClinical implicationsDiseaseSurgeryCurrent literatureSignificant rate
2009
The mechanisms of action of vacuum assisted closure: More to learn
Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: More to learn. Surgery 2009, 146: 40-51. PMID: 19541009, DOI: 10.1016/j.surg.2009.02.002.Peer-Reviewed Original Research
2006
p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress
Kadohama T, Akasaka N, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. p38 Mitogen-Activated Protein Kinase Activation in Endothelial Cell Is Implicated in Cell Alignment and Elongation Induced by Fluid Shear Stress. Endothelium 2006, 13: 43-50. PMID: 16885066, DOI: 10.1080/10623320600660219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesAtherosclerosisBlood PressureBlood VesselsCattleCell PolarityCell ShapeCells, CulturedDose-Response Relationship, DrugEndothelial CellsEnzyme ActivationEnzyme InhibitorsHemodynamicsMAP Kinase Signaling SystemP38 Mitogen-Activated Protein KinasesPhosphorylationRegional Blood FlowStress, MechanicalTime FactorsConceptsStatic endothelial cellsFluid shear stressP38 MAPKP38 Mitogen-Activated Protein Kinase ActivationMitogen-Activated Protein Kinase ActivationEndothelial cellsProtein kinase activationP38 MAPK inhibitor SB-203580Inhibitor SB 203580Cell alignmentProtein kinaseBovine aortic endothelial cellsLaminar shear stressKinase activationSB 203580P38 mitogenCultured bovine aortic endothelial cellsEC elongationAortic endothelial cellsMAPKCellsElongationActivationMorphometric analysisKinase
2004
Effects of Cyclic Strain on Vascular Cells
Kakisis JD, Liapis CD, Sumpio BE. Effects of Cyclic Strain on Vascular Cells. Endothelium 2004, 11: 17-28. PMID: 15203876, DOI: 10.1080/10623320490432452.Peer-Reviewed Original ResearchConceptsCAMP-responsive elementVascular cell morphologyExtracellular mechanical signalsMitogen-activated protein kinaseProtein kinase CPlatelet-derived growth factor receptorEarly growth responseCells senseNumerous genesActivator proteinTranscription factorsProtein kinaseGrowth factor receptorAP-2Chemical signalsSecond messengerKinase CG proteinsMechanical signalsCell nucleiGrowth responseIon channelsCell morphologyFactor receptorCell proliferation
2003
Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain‐induced alignment and proliferation of bovine aortic smooth muscle cells
Li W, Chen Q, Mills I, Sumpio BE. Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain‐induced alignment and proliferation of bovine aortic smooth muscle cells. Journal Of Cellular Physiology 2003, 195: 202-209. PMID: 12652647, DOI: 10.1002/jcp.10230.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCattleCell DivisionCells, CulturedDNA-Binding ProteinsEnzyme InhibitorsImidazolesImmunosuppressive AgentsMAP Kinase Signaling SystemMitogen-Activated Protein KinasesMuscle, Smooth, VascularMyocytes, Smooth MuscleP38 Mitogen-Activated Protein KinasesPyridinesRegional Blood FlowRibosomal Protein S6 KinasesSirolimusStress, MechanicalTranscription FactorsConceptsAortic smooth muscle cellsBovine aortic smooth muscle cellsKinase pathwaySmooth muscle cell phenotypeSmooth muscle cellsStrain-induced proliferationBovine aortic SMCS6 kinaseMuscle cell phenotypeSpecific inhibitorProliferation of SMCsActivation of p38SMC proliferationAortic SMCsMuscle cellsSMC alignment
1994
Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications.
Gusberg RJ, Peterec SM, Sumpio BE, Meier GH. Splenomegaly and variceal bleeding--hemodynamic basis and treatment implications. Hepatogastroenterology 1994, 41: 573-7. PMID: 7721248.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatic VeinsHumansHypertension, PortalLiver Cirrhosis, AlcoholicMaleMonitoring, IntraoperativePortal PressureProspective StudiesRadiographyRegional Blood FlowRetrospective StudiesSplenic VeinSplenomegalySplenorenal Shunt, SurgicalConceptsCirrhotic patientsPortal pressurePortal hypertensionSplenic embolizationVariceal bleedingHemodynamic basisSpleen sizeDistal splenorenal shuntPortal hypertensive patientsSplenic venous flowVariceal bleedersDefinitive therapyHypertensive patientsSplenorenal shuntSplenic enlargementSplenic veinVenous flowHemodynamic significancePatientsSplenomegalySplenic inflowTreatment implicationsHypertensionBleedingSplenectomy