2023
Premature atherosclerosis: A review of current literature
Neifert A, Su D, Chaar C, Sumpio B. Premature atherosclerosis: A review of current literature. JVS-Vascular Insights 2023, 1: 100013. DOI: 10.1016/j.jvsvi.2023.100013.Peer-Reviewed Original ResearchRisk factorsAtherosclerotic diseaseClinical manifestationsGenetic predispositionTraditional atherosclerotic risk factorsHuman immunodeficiency virus (HIV) infectionNontraditional risk factorsActive antiretroviral therapyAtherosclerotic risk factorsImmunodeficiency virus infectionPeripheral arterial diseaseCerebral vascular diseasePremature atherosclerotic diseaseUnique risk factorsRecreational substance useAntiretroviral therapyAutoimmune conditionsDisease-associated lossMetabolic syndromeArterial diseasePremature atherosclerosisLipid derangementsMyocardial infarctionVascular diseaseVirus infection
2015
Preliminary Results of a Smoking Cessation Intervention for Patients With Peripheral Vascular Disease (PVD): A Randomized Controlled Study
Rajaee S, Holder T, Indes J, Muhs B, Sarac T, Sumpio B, Toll B, Chaar C. Preliminary Results of a Smoking Cessation Intervention for Patients With Peripheral Vascular Disease (PVD): A Randomized Controlled Study. Journal Of Vascular Surgery 2015, 61: 88s. DOI: 10.1016/j.jvs.2015.04.171.Peer-Reviewed Original Research
2013
Clinical implications of the angiosome model in peripheral vascular disease
Sumpio BE, Forsythe RO, Ziegler KR, van Baal JG, Lepantalo MJ, Hinchliffe RJ. Clinical implications of the angiosome model in peripheral vascular disease. Journal Of Vascular Surgery 2013, 58: 814-826. PMID: 23972249, DOI: 10.1016/j.jvs.2013.06.056.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseVascular diseaseAngiosome modelVascular surgeryCritical limb ischemiaLarger patient populationReperfusion strategyProspective trialRevascularization attemptsSuccessful revascularizationLimb ischemiaSecondary amputationProspective studyFluorescent angiographyPatient populationVascular operationsAngiosome conceptEndovascular proceduresUnhealed woundsSystematic reviewClinical implicationsDiseaseSurgeryCurrent literatureSignificant rate
2010
The critical role of hemodynamics in the development of cerebral vascular disease.
Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease. Journal Of Neurosurgery 2010, 112: 1240-53. PMID: 19943737, DOI: 10.3171/2009.10.jns09759.Peer-Reviewed Original ResearchConceptsCerebral vascular diseaseVascular diseaseUnique hemodynamic conditionsExtracranial atherosclerosisArtery diseaseIntracranial atherosclerosisIntracranial saccular aneurysmsTreatment optionsVascular disordersHemodynamic parametersAneurysm formationSaccular aneurysmHemodynamic conditionsNormal levelsVascular biologyDiseaseMultiple studiesMore studiesPatient-specific dataAtherosclerosisHemodynamicsMagnitude of WSSRiskLow wall shear stressDisorders
2009
Polyphenols are medicine: Is it time to prescribe red wine for our patients?
Cordova A, Sumpio B. Polyphenols are medicine: Is it time to prescribe red wine for our patients? International Journal Of Angiology 2009, 18: 111-117. PMID: 22477510, PMCID: PMC2903024, DOI: 10.1055/s-0031-1278336.Peer-Reviewed Original ResearchLow physical activityNumerous epidemiological studiesVascular diseaseRisk factorsCardiovascular diseaseChronic pathologiesPhysical activityEpidemiological studiesModerate consumptionElevated smokingFrench paradoxRed wineHigh consumptionDiseaseHigh levelsPolyphenolsSmokingPatientsCancerMortalityPathologyPrevention
2005
In–Vitro Model for Evaluation of the Effects of Supercooling and Re-warming on Vascular Cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro Model for Evaluation of the Effects of Supercooling and Re-warming on Vascular Cells. International Journal Of Angiology 2005, 14: 237-241. DOI: 10.1007/s00547-005-2055-5.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplastyReview of Prevalence and Outcome of Vascular Disease in Patients with Diabetes Mellitus
Weiss JS, Sumpio BE. Review of Prevalence and Outcome of Vascular Disease in Patients with Diabetes Mellitus. European Journal Of Vascular And Endovascular Surgery 2005, 31: 143-150. PMID: 16203161, DOI: 10.1016/j.ejvs.2005.08.015.Peer-Reviewed Original ResearchConceptsLower extremity arterial diseaseLimb salvage rateExtremity arterial diseaseCarotid artery stenosisAbdominal aortic aneurysmMortality riskSalvage rateArterial diseaseArtery stenosisEquivalent mortality riskRisk of complicationsReview of prevalenceAAA prevalencePerioperative morbidityDiabetes mellitusGraft patencyUndergo surgeryAortic aneurysmEquivalent patencyVascular diseaseIncrease prevalenceMorbidity riskEquivalent prevalenceIncrease riskPatientsIn–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells
Yiu W, Aruny J, Cheng S, Sumpio B. In–Vitro model for evaluation of the effects of supercooling and re-warming on vascular cells. International Journal Of Angiology 2005, 237-241. DOI: 10.1055/s-0031-1276516.Peer-Reviewed Original ResearchInitial technical success rateEndothelial cellsRe-warming phasePeripheral vascular diseaseTransluminal balloon angioplastyRate of restenosisTechnical success rateTUNEL-positive cellsSmooth muscle cellsBalloon angioplastyVascular diseaseEndothelial cell survivalMuscle cellsVascular cellsVitro modelVessel wallSuccess rateUnderlying mechanismRestenosisCell survivalCellsCellular responsesCritical roleAngioplasty
2004
The Multidisciplinary Approach to Limb Salvage
Sumpio BE, Aruny J, Blume PA. The Multidisciplinary Approach to Limb Salvage. Acta Chirurgica Belgica 2004, 104: 647-653. PMID: 15663269, DOI: 10.1080/00015458.2004.11679637.Peer-Reviewed Original ResearchConceptsNon-diabetic patientsPrimary care physiciansMultidisciplinary approachLower extremity woundsComprehensive treatment protocolAggressive treatmentConsiderable morbidityLimb salvageCare physiciansMetabolic derangementsVascular diseaseClinical trialsExtremity woundsVascular surgeonsTreatment protocolLower limbsFoot abnormalitiesPlastic surgeonsCareful assessmentPatientsPodiatristsPhysiciansSurgeonsMorbidityUlceration
2003
Thrombospondin‐1‐induced vascular smooth muscle cell chemotaxis: The role of the type 3 repeat and carboxyl terminal domains
Lee T, Nesselroth SM, Olson ET, Esemuede N, Lawler J, Sumpio BE, Gahtan V. Thrombospondin‐1‐induced vascular smooth muscle cell chemotaxis: The role of the type 3 repeat and carboxyl terminal domains. Journal Of Cellular Biochemistry 2003, 89: 500-506. PMID: 12761883, DOI: 10.1002/jcb.10524.Peer-Reviewed Original ResearchConceptsVSMC chemotaxisThrombospondin-1Acute phase reactantsSmooth muscle cell chemotaxisVascular diseaseVascular smooth muscle cell chemotaxisPhase reactantsExtracellular signal-regulated kinases 1Microchemotaxis chamberSignal-regulated kinases 1Serum-free mediumCell chemotaxisMatricellular glycoproteinActivate ERKWestern immunoblottingVSMCsT-testP38 activationP38 pathwayERKFusion proteinT3ChemotaxisKinase 1P38 kinase
2001
The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis
Nesselroth S, Willis A, Fuse S, Olson E, Lawler J, Sumpio B, Gahtan V. The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis. Journal Of Vascular Surgery 2001, 33: 595-600. PMID: 11241132, DOI: 10.1067/mva.2001.112318.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVSMC chemotaxisThrombospondin-1VSMC migrationAortic vascular smooth muscle cellsTop wellsAcute phase reactantsBoyden chamber chemotaxisSmooth muscle cellsSmooth muscle cell chemotaxisVascular diseaseVascular lesionsVascular smooth muscle cell chemotaxisSerum-free mediumMuscle cellsTSP-1 moleculeCell chemotaxisChemotaxis assaysBottom wellsAntibodiesSelective inhibitionT-test
2000
Foot Ulcers
Sumpio BE. Foot Ulcers. New England Journal Of Medicine 2000, 343: 787-793. PMID: 10984568, DOI: 10.1056/nejm200009143431107.Peer-Reviewed Original ResearchConceptsPrimary care physiciansComprehensive treatment protocolMajor amputationPedal woundsAggressive treatmentFoot complicationsCare physiciansFoot ulcersVascular diseaseEarly recognitionRisk factorsPatient educationBiomechanical abnormalitiesTreatment protocolPrevents infectionOptimal managementSkin integrityCareful assessmentMultidisciplinary approachInfectionUlcerationComplicationsUlcersAmputationManagementVASCULAR ASSESSMENT
Collins K, Sumpio B. VASCULAR ASSESSMENT. Clinics In Podiatric Medicine And Surgery 2000, 17: 171-191. PMID: 10810651, DOI: 10.1016/s0891-8422(23)01121-7.Peer-Reviewed Original ResearchConceptsVascular testingClinical syndromePeripheral vascular diseaseDistinct clinical syndromeNoninvasive vascular laboratoryGrade lesionsSurgical interventionVascular assessmentVascular statusAdjunctive usePhysical examinationThorough historyVascular diseasePeripheral vasculatureVascular laboratoryContrast angiographyClinical scenariosInvasive methodPatientsSyndromeInterventionAngiographyLesionsDiseaseTestingDiabetic Vascular Disease: Biochemical and Molecular Perspectives
Kamal K, Chang R, Sumpio B. Diabetic Vascular Disease: Biochemical and Molecular Perspectives. 2000, 817-834. DOI: 10.1007/978-1-4612-1190-7_68.Peer-Reviewed Original ResearchDiabetes mellitusChronic complicationsMajor chronic complicationsEnd-organ damageCharacteristic pathological featuresDiscovery of insulinDiabetic patientsDiabetic angiopathyMetabolic abnormalitiesChronic hyperglycemiaPathological featuresVascular diseaseMellitusNatural historyComplicationsDiabetesPatientsAngiopathyMorbidityHyperglycemiaNerveKidneyMortalityAbnormalitiesInsulinTissue Plasminogen Activator: Biological and Physiological Relevance for Vascular Surgeons
Chang R, Kamal K, Sumpio B. Tissue Plasminogen Activator: Biological and Physiological Relevance for Vascular Surgeons. 2000, 1315-1323. DOI: 10.1007/978-1-4612-1190-7_103.Peer-Reviewed Original ResearchTissue-type plasminogen activatorThrombolytic therapyDeep venous thrombosisOcclusive vascular diseaseEfficacy of treatmentCerebrovascular accidentPulmonary embolismVenous thrombosisClinical outcomesMyocardial infarctionVascular diseaseVascular surgeonsHuman trialsEffective treatmentThrombolytic agentsPlasminogen activatorTherapyPhysiological relevanceTreatmentEndogenous propertiesEmbolismInfarctionThrombosisPatientsAgents
1998
Understanding molecular biology.
Gahtan V, Peyman JA, Sumpio BE. Understanding molecular biology. Seminars In Vascular Surgery 1998, 11: 125-33. PMID: 9763112.Peer-Reviewed Original Research
1996
Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease.
Pena C, McCauley T, Price T, Sumpio B, Gusberg R, Gore J. Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease. American Journal Of Roentgenology 1996, 167: 153-7. PMID: 8659362, DOI: 10.2214/ajr.167.1.8659362.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseAnkle-brachial indexAbnormal ankle-brachial indexVascular diseaseVolume blood flowBlood flow measurementsBlood flowCine phase-contrast MR imagingLarger patient groupsPhase-contrast MR imagingPlantar flexion exerciseOlder normal volunteersVolume blood flow measurementsPopliteal arteryPatient groupFlexion exerciseNormal volunteersPatientsTriphasic waveformQuantitative blood flow measurementsFlow increasesMR imagingDiseaseVolunteersSimilar age
1995
Multicenter Trial to Evaluate Vascular Magnetic Resonance Angiography of the Lower Extremity
Baum R, Rutter C, Sunshine J, Blebea J, John, Carpenter J, Dickey K, Quinn S, Gomes A, Grist T, McNeil B, Axel L, Holland G, Cope C, Haskal Z, Shlansky-Goldberg R, Soulen M, Vu D, Alspaugh J, Fowl R, Kempczinski R, McCauley T, Egglin T, Pollak J, Rosenblatt M, Burdge C, Gusberg R, Meier G, Sumpio B, Demlow T, Peterson B, Swan J, Sproat I, Hoch J, Acher C, Yoon H, Quinones-Baldrich W, Moore W, Ahn S, Caldwell T. Multicenter Trial to Evaluate Vascular Magnetic Resonance Angiography of the Lower Extremity. JAMA 1995, 274: 875-880. DOI: 10.1001/jama.1995.03530110037032.Peer-Reviewed Original ResearchMagnetic resonance angiographyContrast arteriographyPatent segmentsResonance angiographyTreatment planNormal segmentsPeripheral vascular diseaseAtherosclerotic occlusive diseaseRest painOcclusive diseaseConsecutive patientsMulticenter trialProspective studySurgical interventionPresurgical evaluationVascular diseaseCommunity hospitalContrast angiographyTechnology assessmentLogistic analysisLower ExtremityTissue lossUS hospitalsPlanning treatmentArterial segments
1993
Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease
Widmann M, Sumpio B. Lipoprotein (a): A Risk Factor for Peripheral Vascular Disease. Annals Of Vascular Surgery 1993, 7: 446-451. PMID: 8268090, DOI: 10.1007/bf02002128.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseCoronary artery diseaseDiabetes mellitusCigarette smokingRisk factorsCerebrovascular atherosclerotic diseaseWhite male patientArtery diseaseMale patientsAtherosclerotic diseasePlasma levelsVascular diseasePatientsDiseaseSerum proteinsMellitusComplicationsSmokingLipoproteinControl of smooth muscle cell proliferation by psoralen photochemotherapy.
Sumpio B, Phan S, Gasparro F, Deckelbaum L. Control of smooth muscle cell proliferation by psoralen photochemotherapy. Journal Of Vascular Surgery 1993, 17: 1010-6; discussion 1016-8. PMID: 8505779, DOI: 10.1067/mva.1993.45747.Peer-Reviewed Original ResearchConceptsSmooth muscle cell proliferationMuscle cell proliferationSMC proliferationPsoralen photochemotherapyPeripheral vascular diseaseLong-term therapyCell proliferationInhibits SMC proliferationTrypan blue exclusionBypass graftDistal anastomosisBalloon angioplastyUVA photochemotherapyVascular diseaseIntimal hyperplasiaGrowth of SMCsBlue exclusionPhotochemotherapySMC viabilityTime courseProliferationUVADNA synthesisDaysAngioplasty