2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groupsMolecular Imaging Targets in Heart Failure and Left Ventricular Remodeling
Boutagy N, Feher A, Sikanderkhel S, Sinusas A. Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling. 2019, 405-435. DOI: 10.1002/9781118754467.ch13.ChaptersHeart failureManagement of HFMultimodality cardiovascular imagingMolecular imaging targetsMagnetic resonance imagingPositron emission tomographySingle photon emissionExtracellular matrix depositionCardiac injuryVentricle remodelingVentricular remodelingStandard clinical toolResonance imagingEmission tomographyClinical toolCompensatory mechanismsCardiac perfusionCardiovascular imagingNuclear imaging modalitiesImaging modalitiesImaging targetsPhoton emissionMatrix depositionNoninvasive measurementMolecular imaging
2016
Association of Right Ventricular Pressure and Volume Overload with Non-Ischemic Septal Fibrosis on Cardiac Magnetic Resonance
Kim J, Medicherla CB, L. C, Feher A, Kukar N, Geevarghese A, Goyal P, Horn E, Devereux RB, Weinsaft JW. Association of Right Ventricular Pressure and Volume Overload with Non-Ischemic Septal Fibrosis on Cardiac Magnetic Resonance. PLOS ONE 2016, 11: e0147349. PMID: 26799498, PMCID: PMC4723145, DOI: 10.1371/journal.pone.0147349.Peer-Reviewed Original ResearchConceptsPulmonary artery systolic pressureNon-ischaemic fibrosisCardiac magnetic resonanceRV dysfunctionAdverse right ventricular (RV) remodelingRV end-systolic volumeWall stressRV pressure loadRV wall stressRight ventricular remodelingRight ventricular pressureEnd-systolic volumeLower RVEFSimilar LVEFLV dysfunctionRV dilationRV sizeSeptal fibrosisMultivariable analysisSystolic pressureVolume overloadChamber dilationPoor prognosisTransthoracic echoVentricular remodeling