2024
Stem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus
Fraser E, Kennedy J, Gianakos A, Yasui Y. Stem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus. 2024, 47-56. DOI: 10.1201/9781003524205-7.Peer-Reviewed Original Research
2023
Talonavicular Osteochondral Lesions: Surgical Technique and Clinical Outcomes from the Boston and Amsterdam Perspectives
Rikken Q, Dahmen J, Gianakos A, Bejarano-Pineda L, Waryasz G, DiGiovanni C, Stufkens S, Kerkhoffs G. Talonavicular Osteochondral Lesions: Surgical Technique and Clinical Outcomes from the Boston and Amsterdam Perspectives. Cartilage 2023, 15: 26-36. PMID: 37750492, PMCID: PMC10985397, DOI: 10.1177/19476035231200334.Peer-Reviewed Original ResearchPatient-reported outcome measuresSymptomatic osteochondral lesionsSurgical treatmentOsteochondral lesionsTalonavicular jointSurgical techniqueArthroscopic surgical treatmentMajority of patientsRetrospective case seriesPatient-reported outcomesOpen surgical approachLevel of sportFinal followIndex surgeryPatient-specific treatment plansPostoperative complicationsReoperation ratePreinjury levelCase seriesClinical outcomesSurgical approachMedical recordsOperative techniqueOutcome measuresIndependent reviewersRethinking Cartilage Lesions of the Ankle: An Update on the Role of Biologic Adjuvants
Gianakos A, Kennedy J. Rethinking Cartilage Lesions of the Ankle: An Update on the Role of Biologic Adjuvants. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 701-707. PMID: 37026780, DOI: 10.5435/jaaos-d-22-01042.Peer-Reviewed Original ResearchAdvances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role?
Gianakos A, Okedele O, Mulcahey M, Kerkhoffs G, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus—Does Sex Play a Role? The Journal Of Foot & Ankle Surgery 2022, 62: 96-101. PMID: 35753861, DOI: 10.1053/j.jfas.2022.05.005.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationFemale patientsOsteochondral lesionsMale patientsOsteochondral transplantationPotential gender-related differencesCartilage repair tissue (MOCART) scoreMean MOCART scoreAnkle Outcome ScoreMechanism of injuryChronic ankle instabilityTalar osteochondral lesionsGender-related differencesMean FAOSConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMOCART scoreAnkle instabilityPatientsDemographic dataTissue scoresLesionsRehabilitation strategiesGender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Gianakos A, Williamson E, Mercer N, Kerkhoffs G, Kennedy J. Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. The Journal Of Foot & Ankle Surgery 2022, 62: 75-79. PMID: 35659478, DOI: 10.1053/j.jfas.2022.04.010.Peer-Reviewed Original ResearchConceptsBone marrow stimulationMale patientsFemale patientsPain scoresOsteochondral lesionsMarrow stimulationCartilage repair tissue (MOCART) scoreSymptomatic osteochondral lesionsAnkle Outcome ScoreShort Form-12Mechanism of injuryMagnetic resonance observationYears postsurgeryClinical outcomesOutcome scoresSurgical outcomesRetrospective analysisAnkle biomechanicsPatientsMedial lesionsLateral lesionsLesionsTissue scoresCartilage morphologyOutcomesAutologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Mulcahey M, Kennedy J. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2022, 7: 2473011421s00204. PMCID: PMC8795102, DOI: 10.1177/2473011421s00204.Peer-Reviewed Original ResearchAutologous osteochondral transplantationTalar osteochondral lesionsFemale patientsMale patientsChronic ankle instabilityOsteochondral lesionsOsteochondral transplantationAnkle instabilityKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSFAOS scoresSymptom durationComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeRevision surgeryMOCART scorePatientsGender May Affect Mid-Term Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Gianakos A, Williamson E, Kennedy J. Gender May Affect Mid-Term Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00205. PMCID: PMC8794953, DOI: 10.1177/2473011421s00205.Peer-Reviewed Original ResearchBone marrow stimulationMale patientsFemale patientsPain scoresMagnetic resonance imagingOsteochondral lesionsLateral lesionsMarrow stimulationMean MOCART scoreSymptomatic osteochondral lesionsMean patient ageMid-term outcomesAnkle Outcome ScoreShort Form-12Treatment of OLTSignificant differencesCartilage repair tissueConcomitant proceduresPatient ageMagnetic resonance observationClinical outcomesOutcome scoresSurgical interventionMOCART scoreTraumatic etiologyLong-Term Outcomes of Autograft Osteochondral Transplantation for Osteochondral Lesions of the Talus: Eight to Twelve Years Follow-Up
Gianakos A, Mercer N, Dankert J, Kennedy J. Long-Term Outcomes of Autograft Osteochondral Transplantation for Osteochondral Lesions of the Talus: Eight to Twelve Years Follow-Up. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00206. PMCID: PMC8795146, DOI: 10.1177/2473011421s00206.Peer-Reviewed Original ResearchAutologous osteochondral transplantationPain subscaleRadiographic outcomesOsteochondral transplantationOsteochondral lesionsShort Form-12 (SF-12) general health questionnaireOverall clinical failure rateMean MOCART scoreMean SF-12Ankle Outcome ScoreMean VAS scoreRetrospective case seriesClinical failure rateTreatment of OLTPost-operative MRITotal ankle replacementTreatment of lesionsGeneral Health QuestionnaireQuality of lifeAnkle debridementCartilage repair tissueVAS scoresAdditional surgeryMagnetic resonance observationCase series
2020
Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes?
Gianakos A, Okedele O, Flynn S, Kennedy J, DiGiovanni C. Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: Does Gender Impact Outcomes? Foot & Ankle Orthopaedics 2020, 5: 2473011420s00227. PMCID: PMC8696434, DOI: 10.1177/2473011420s00227.Peer-Reviewed Original ResearchAutologous osteochondral transplantationFemale patientsTalar osteochondral lesionsOsteochondral lesionsMale patientsMOCART scoreOsteochondral transplantationKnee donor-site morbidityCartilage repair tissue (MOCART) scoreMean MOCART scoreLonger symptom durationAnkle Outcome ScoreDonor site morbidityMean FAOSSymptom durationFAOS scoresComplication rateConsecutive patientsMagnetic resonance observationOutcome scoresFunctional outcomeMean MRIRevision surgeryPatientsLesion sizeOutcomes Following Microfracture for Osteochondral Lesions of the Talus in Female Patients
Williamson E, Gianakos A, Hurley E, Kennedy J. Outcomes Following Microfracture for Osteochondral Lesions of the Talus in Female Patients. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00495. PMCID: PMC8696304, DOI: 10.1177/2473011420s00495.Peer-Reviewed Original ResearchMagnetic resonance imagingCartilage repair tissueFemale patientsMOCART scoreOsteochondral lesionsPostoperative FAOS scoresSymptomatic osteochondral lesionsMean patient ageAnkle Outcome ScoreShort Form-12Treatment of OLTSF-12 scoresLong-term outcomesRepair tissueBone marrow stimulationFAOS scoresFurther surgeryMagnetic resonance observationPatient ageClinical outcomesOutcome scoresTerm outcomesDistraction arthroplastyRetrospective analysisPatientsAutologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population
Seow D, Shimozono Y, Gianakos A, Chiarello E, Mercer N, Hurley E, Kennedy J. Autologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population. Knee Surgery, Sports Traumatology, Arthroscopy 2020, 29: 1554-1561. PMID: 32856096, DOI: 10.1007/s00167-020-06216-w.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationQuality of evidenceOLT sizeRehabilitation protocolOsteochondral transplantationAthletic populationOsteochondral lesionsSystematic reviewPre-injury statusCochrane Library databasesLevel of evidencePredictors of returnSpecific eligibility criteriaHigh rateFixed-effects modelLevel IVSurgeons' protocolsLibrary databasesPRISMA guidelinesEligibility criteriaSubsequent rehabilitationIncrease ageMean timeSignificant correlationTransplantation
2019
Return to Play and Rehabilitation Protocols following Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis
Shimozono Y, Seow D, Gianakos A, Chiarello E, Kennedy J. Return to Play and Rehabilitation Protocols following Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus: A Systematic Review and Meta-Analysis. Foot & Ankle Orthopaedics 2019, 4: 2473011419s00392. PMCID: PMC8697143, DOI: 10.1177/2473011419s00392.Peer-Reviewed Original ResearchAutologous osteochondral transplantationModified Coleman Methodology ScoreQuality of evidenceRehabilitation protocolSystematic reviewOsteochondral transplantationOsteochondral lesionsStandardized rehabilitation protocolPercentage of patientsPre-injury statusColeman Methodology ScoreCochrane Library databasesInclusion/exclusion criteriaMeta-Analyses (PRISMA) guidelinesRange of motionPreferred Reporting ItemsSpecific inclusion/exclusion criteriaHigh rateFixed-effects modelOLT sizePartial weightbearingFull weightbearingMethodology ScoreFavorable outcomeAthletic population
2017
Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review
Gianakos A, Sun L, Patel J, Adams D, Liporace F. Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review. World Journal Of Orthopedics 2017, 8: 491-506. PMID: 28660142, PMCID: PMC5478493, DOI: 10.5312/wjo.v8.i6.491.Peer-Reviewed Original ResearchConcentrated bone marrow aspirateBone marrow aspirateTendon repairTendon injuriesMarrow aspiratesCartilaginous lesionsSystematic reviewClinical settingFull-thickness chondral lesionsSignificant clinical improvementQuality of evidenceInclusion/exclusion criteriaLevel of evidenceStandardized outcome measuresMagnetic resonance imagingClinical improvementAdjunctive treatmentBone unionDecreased riskLower incidenceChondral lesionsOutcome measuresExclusion criteriaHealing rateOsteochondral lesionsCurrent management of talar osteochondral lesions
Gianakos A, Yasui Y, Hannon C, Kennedy J. Current management of talar osteochondral lesions. World Journal Of Orthopedics 2017, 8: 12-20. PMID: 28144574, PMCID: PMC5241540, DOI: 10.5312/wjo.v8.i1.12.Peer-Reviewed Original ResearchAutologous osteochondral transplantationBone marrow stimulationReparative proceduresOsteochondral lesionsConcentrated bone marrow aspiratePrimary repair proceduresAcute ankle sprainsTreatment of OLTMedium-term resultsBone marrow aspirateTalar osteochondral lesionsDate clinical evidencePlatelet-rich plasmaDiagnostic imaging modalitiesAOT procedureSymptomatic OLTAdjunct therapyClinical evidenceSurgical outcomesAnkle sprainSurgical techniqueTreatment strategiesMarrow aspiratesOsteochondral transplantationLarge lesions
2015
Anterolateral Tibial Osteotomy for Accessing Osteochondral Lesions of the Talus in Autologous Osteochondral Transplantation
Gianakos A, Hannon C, Ross K, Newman H, Egan C, Deyer T, Kennedy J. Anterolateral Tibial Osteotomy for Accessing Osteochondral Lesions of the Talus in Autologous Osteochondral Transplantation. Foot & Ankle International 2015, 36: 531-538. PMID: 25576475, DOI: 10.1177/1071100714563308.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationAnterolateral tibial osteotomyTibial osteotomyOutcome scoresOsteochondral transplantationOsteochondral lesionsMagnetic resonance imaging outcomesCystic osteochondral lesionsPrimary treatment strategyAnkle Outcome ScoreFunctional outcome scoresRetrospective case seriesRecords of patientsSeries of patientsRepair siteRepair tissueAverage MOCART scoreT2 mapping MRIBone marrow stimulationCartilage repair tissuePostoperative footLigament disruptionLimited morbidityMagnetic resonance observationCase series