2024
Interstitial Lung Diseases and Non-Small Cell Lung Cancer: Particularities in Pathogenesis and Expression of Driver Mutations
Sampsonas F, Bosgana P, Bravou V, Tzouvelekis A, Dimitrakopoulos F, Kokkotou E. Interstitial Lung Diseases and Non-Small Cell Lung Cancer: Particularities in Pathogenesis and Expression of Driver Mutations. Genes 2024, 15: 934. PMID: 39062713, PMCID: PMC11276289, DOI: 10.3390/genes15070934.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseLung cancerLung diseaseDriver mutationsImproved survivalTreatment optionsChronic inflammationPathogenetic pathwaysNon-small cell lung cancerConcurrent interstitial lung diseaseCell lung cancerSites of chronic inflammationAnti-fibrotic medicationsCurrent treatment optionsIdiopathic pulmonary fibrosisDiseases associated with chronic inflammationIncidence of lung cancerPersonalized medicine approachPrompt diagnosisClinical entityNon-smallPulmonary fibrosisNSCLCSurvival ratePatientsModified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis
Kreuter M, Lee J, Tzouvelekis A, Oldham J, Molyneaux P, Weycker D, Atwood M, Samara K, Kirchgässler K, Maher T. Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis. ERJ Open Research 2024, 10: 00666-2023. PMID: 39076530, PMCID: PMC11284599, DOI: 10.1183/23120541.00666-2023.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisWhite blood cellsRed blood cellsNeutrophil countMonocyte countPulmonary fibrosisHemoglobin levelsRandomised phase III trialBaseline white blood cellC-statisticIPF outcomesBlood cellsTrials of pirfenidoneIdiopathic pulmonary fibrosis progressionImprove prediction of outcomeRed blood cell variablesBlood cell countPredictive of outcomeStudy outcomesRed blood cell parametersMortality prediction toolRespiratory-related hospitalisationEosinophil countRetrospective analysisMultivariate analysis
2016
Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells
Yu G, Tzouvelekis A, Wang R, Herazo-Maya J, Srivastava A, Woolard T, Mannam P, Lee P, Bianco A, Kaminski N. Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells. QJM 2016, 109: s9-s9. DOI: 10.1093/qjmed/hcw124.001.Peer-Reviewed Original ResearchP063 The Distribution and Efficacy of MiR-29 Mimicry as a Therapy for Pulmonary Fibrosis Induced by Bleomycin in Mice
Yu G, Wang R, Ibarra G, Tzouvelekis A, Woolard T, herazo-maya J, Sakamoto K, Li Q, Deluliis G, Ahnangari F, Vukmirovic M, Aurelien N, Adams T, Munivar A, Kaminski N. P063 The Distribution and Efficacy of MiR-29 Mimicry as a Therapy for Pulmonary Fibrosis Induced by Bleomycin in Mice. QJM 2016, 109: s42-s43. DOI: 10.1093/qjmed/hcw124.036.Peer-Reviewed Original ResearchPulmonary fibrosisFibrosis