2022
HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation
Wu L, Shukla V, Yadavalli AD, Dinesh RK, Xu D, Rao A, Schatz DG. HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes & Development 2022, 36: 433-450. PMID: 35450882, PMCID: PMC9067407, DOI: 10.1101/gad.349438.122.Peer-Reviewed Original Research
2021
A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes
Nikhat S, Yadavalli AD, Prusty A, Narayan PK, Palakodeti D, Murre C, Pongubala JMR. A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2104297118. PMID: 34750254, PMCID: PMC8609617, DOI: 10.1073/pnas.2104297118.Peer-Reviewed Original ResearchConceptsMultipotent progenitorsCell type-specific genesDe novo motif analysisLymphocyte developmentLineage-inappropriate genesHematopoietic multipotent progenitorsSilencing of genesType-specific genesGene expression programsNovo motif analysisEarly T-lymphocyte developmentAlternate cell fatesCell-autonomous mannerGene expression patternsLineage determinantsMyeloid differentiation potentialExpression programsCell fateMiRNAs functionMotif analysisParticular lineageT lymphocyte developmentRegulatory networksLineage commitmentMiRNA targetome