2024
The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program
Chen G, Shipman W, Hodelin C, Hsia H, Cohen J, Eisenstein A. The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, llae521. PMID: 39573984, DOI: 10.1093/ced/llae521.Peer-Reviewed Original ResearchCigarette smokingOdds of cigarette smokingElectronic health recordsHealth research programsCannabis useCross-sectional studyCross sectional studyHealth recordsSectional studySmokingHidradenitis suppurativaNational InstituteSurvey dataAssociationCannabisOddsUseCigaretteHidradenitisResearch programNationalProgramPopulationStudy059 Industrial compounds mediate allergic sensitization
Eisenstein A, Brown-Soler I, Hilliard B, Wang A. 059 Industrial compounds mediate allergic sensitization. Journal Of Investigative Dermatology 2024, 144: s10. DOI: 10.1016/j.jid.2024.06.075.Peer-Reviewed Original ResearchEfficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta‐analysis
Shipman W, Williams M, Suozzi K, Eisenstein A, Dover J. Efficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta‐analysis. Lasers In Surgery And Medicine 2024, 56: 425-436. PMID: 38769894, DOI: 10.1002/lsm.23796.Peer-Reviewed Original ResearchLong-pulsed Nd:YAG laserHS disease severityHidradenitis suppurativaLaser hair removalMinimal adverse effectsTreatment optionsDisease severityMeta-analysisLaser modalitiesLong-pulse neodymium-doped yttrium aluminum garnetAdverse effectsEffective treatment optionEffects of laser hair removalChronic inflammatory conditionsSystematic reviewComprehensive literature searchStandardized mean differenceHair removalRandomized controlled trialsFollicular occlusionNeodymium-doped yttrium aluminum garnetCase seriesHair-bearing areasPainful nodulesHS pathogenesis
2022
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity 2022, 55: 1082-1095.e5. PMID: 35588739, PMCID: PMC9205175, DOI: 10.1016/j.immuni.2022.04.015.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsAnti-inflammatory propertiesMyeloid cellsPrescription nonsteroidal anti-inflammatory drugsGrowth/differentiation factor 15Anti-inflammatory effectsDifferentiation factor 15Myeloid-specific deletionAnti-inflammatory activityAnti-inflammatory drugsNrf2-dependent mechanismKelch-like ECHTranscription factor Nrf2NSAID usageClinical outcomesCOX inhibitionPharmacologic approachesFactor 15Murine modelTissue protectionMurine myeloid cellsNuclear factorPrimary humanFactor Nrf2Nrf2
2021
Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man
Choi R, Ko C, Eisenstein A. Skin-limited Langerhans cell histiocytosis presenting as crusted papules in an acneiform distribution in an adolescent man. JAAD Case Reports 2021, 20: 37-39. PMID: 35036502, PMCID: PMC8753055, DOI: 10.1016/j.jdcr.2021.11.024.Peer-Reviewed Original Research
2020
Food Allergy: Searching for the Modern Environmental Culprit.
Eisenstein AS, Hilliard B, Silwal S, Wang A. Food Allergy: Searching for the Modern Environmental Culprit. The Yale Journal Of Biology And Medicine 2020, 93: 733-747. PMID: 33380935, PMCID: PMC7757057.Peer-Reviewed Original ResearchBone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis
Eisenstein A, Chitalia S, Ravid K. Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis. International Journal Of Molecular Sciences 2020, 21: 7470. PMID: 33050467, PMCID: PMC7589187, DOI: 10.3390/ijms21207470.Peer-Reviewed Original ResearchConceptsBone healthBone marrowPotential therapeutic targetInhibitory receptorsMetabolic disturbancesReceptor effectsTherapeutic implicationsTherapeutic targetMetabolic diseasesEndogenous ligandDichotomous effectsReceptorsMarrowAdenosineAdipogenesisExpression profilesCellular stressHealthOsteogenesisCurrent understandingDifferent tissuesObesityInflammationDisease051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitization
Eisenstein A, Hilliard B, Wang A. 051 Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitization. Journal Of Investigative Dermatology 2020, 140: s5. DOI: 10.1016/j.jid.2020.03.053.Peer-Reviewed Original Research
2018
Emerging Biomarkers in Cutaneous Melanoma.
Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM. Emerging Biomarkers in Cutaneous Melanoma. Molecular Diagnosis & Therapy 2018, 22: 203-218. PMID: 29411301, DOI: 10.1007/s40291-018-0318-z.Peer-Reviewed Original ResearchQuantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions
Eisenstein A, Panova IP, Chung HJ, Goldberg LJ, Zhang Q, Lazova R, Bhawan J, Busam KJ, Symanowski JT, Alani RM, Ryu B. Quantitative assessment of neuropilin-2 as a simple and sensitive diagnostic assay for spitzoid melanocytic lesions. Melanoma Research 2018, 28: 71-75. PMID: 29227334, PMCID: PMC5805139, DOI: 10.1097/cmr.0000000000000416.Peer-Reviewed Original Research
2015
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases
Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. Journal Of Cellular Physiology 2015, 230: 2891-2897. PMID: 25975415, PMCID: PMC4811601, DOI: 10.1002/jcp.25043.Peer-Reviewed Original Research
2014
An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*
Eisenstein A, Carroll S, Johnston-Cox H, Farb M, Gokce N, Ravid K. An Adenosine Receptor-Krüppel-like Factor 4 Protein Axis Inhibits Adipogenesis*. Journal Of Biological Chemistry 2014, 289: 21071-21081. PMID: 24928509, PMCID: PMC4110311, DOI: 10.1074/jbc.m114.566406.Peer-Reviewed Original ResearchConceptsKruppel-like factor 4Regulator of stem cell maintenanceRegulator of adipocyte differentiationStem cell maintenanceInhibit differentiationRegulator of adipogenesisAdenosine receptorsKnockdown of KLF4Adipose tissue of obese subjectsAdipose tissue developmentExtracellular ligandsA2B adenosine receptorsKruppel-like factor 4 expressionCell maintenanceExpression of Kruppel-like factor 4Signaling cascadesSignaling moleculesAdipocyte differentiationAdipose biologyStromal vascular cellsTissue developmentAdipocyte progenitorsInhibit adipogenesisObese subjectsA2bAR activationThe Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity
Johnston-Cox H, Eisenstein A, Koupenova M, Carroll S, Ravid K. The Macrophage A2b Adenosine Receptor Regulates Tissue Insulin Sensitivity. PLOS ONE 2014, 9: e98775. PMID: 24892847, PMCID: PMC4043770, DOI: 10.1371/journal.pone.0098775.Peer-Reviewed Original ResearchConceptsInsulin resistanceControl miceLevel of control miceHFD-induced insulin resistanceA2B adenosine receptorsRelease of inflammatory cytokinesHigh-fat diet (HFD)-induced type 2 diabetesInsulin receptor 2Cyclic adenosine monophosphateTissue insulin sensitivityRegulation of inflammationTissue insulin resistanceTissue insulin signalingType 2 diabetesTransgenic mouse modelA2BAR expressionA2BAR signalingInsulin signalingReceptor influenceTissue inflammationNull backgroundNull miceReceptor 2Adenosine receptorsLiver inflammationIntegration of Basic Science and Clinical Medicine
Eisenstein A, Vaisman L, Johnston-Cox H, Gallan A, Shaffer K, Vaughan D, O’Hara C, Joseph L. Integration of Basic Science and Clinical Medicine. Academic Medicine 2014, 89: 50-53. PMID: 24280854, DOI: 10.1097/acm.0000000000000054.Peer-Reviewed Original ResearchMeSH KeywordsAnatomyBiological Science DisciplinesBiopsyBostonCadaverClinical CompetenceCurriculumEducation, Medical, UndergraduateEducational MeasurementEvidence-Based MedicineHistologyHumansModels, EducationalOrganizational InnovationPathologyProgram DevelopmentProgram EvaluationRadiologySchools, MedicalStudents, MedicalConceptsMedical education reformStudents' first experiencesCase-based learningMedical education initiativesCompetency-based outcomesEducation reformBoston University School of MedicineScience contentIntegrated curriculumCurricular innovationsCurricular designCurricular integrationStu-dentsScience coursesSenior medical studentsIntegration of topicsGross anatomy courseEducational initiativesTest scoresMedical stu-dentsEducational interventionAnatomy courseAcquired skillsPatient careStudents
2013
G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors
Eisenstein A, Ravid K. G Protein‐Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors. Journal Of Cellular Physiology 2013, 229: 414-421. PMID: 24114647, PMCID: PMC4362544, DOI: 10.1002/jcp.24473.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsAdenosine receptorsExtracellular signalsAdenosine signalingObesity epidemicMetabolic consequencesDevelopment of therapeuticsBlood flowDownstream messengersReceptorsTranscriptional eventsAdipose tissueMature adipocytesAdipocyte differentiationCellular differentiationMetabolic homeostasisAdenosineCoupled receptorsAdipocytesPhysiological outcomesDifferentiation processExcess nutrientsRegulation functionAdipogenesisDifferentiationA2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4
Eisenstein A, Ravid K. A2b adenosine receptor regulation of adipocyte precursor fate and lineage determination: identification of a novel link to the stem cell factor KLF4. The FASEB Journal 2013, 27: 599.1-599.1. DOI: 10.1096/fasebj.27.1_supplement.599.1.Peer-Reviewed Original ResearchIn vivo BrdU labelingA2BAR KO miceBay 60-6583A2B adenosine receptorsStem cell factorWild type miceAdipocyte differentiationHigh-fat diet feedingActivate adenylyl cyclaseA2BAR signalingAssociated with cellular proliferationFat diet feedingAdenosine signalingKO miceType miceSpecific agonistsStromal vascular fractionStem cell fateCell factorAdenosine receptorsInhibited adipocyte differentiationPrecursor proliferationA2BARAdenylyl cyclaseMesenchymal stem cells
2012
A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors
Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam W, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal Of Cell Science 2012, 125: 4507-4517. PMID: 22767505, PMCID: PMC3500865, DOI: 10.1242/jcs.105023.Peer-Reviewed Original ResearchConceptsExpression of anti-NFkB activationC-terminusEctopic expressionP105 proteinsAdenosine receptorsTranscription factor NFKB1A(2B) adenosine receptorsInhibited NFkB activationPolyubiquitylationSpecific sitesA2B adenosine receptorsLigand activationNFkB pathwayP105Interleukin (IL)-10Nuclear factor kappa BProtein levelsTumor necrosis factorPro-inflammatory cytokinesFactor kappa BRegulationIL-12PathwayTNF-a
2010
Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival
Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, Fiore C, Qiu W, Fiorentino M, Finn S, Penney KL, Eisenstein A, Schumacher FR, Mucci LA, Stampfer MJ, Giovannucci E, Loda M. Fatty Acid Synthase Polymorphisms, Tumor Expression, Body Mass Index, Prostate Cancer Risk, and Survival. Journal Of Clinical Oncology 2010, 28: 3958-3964. PMID: 20679621, PMCID: PMC2940394, DOI: 10.1200/jco.2009.27.0793.Peer-Reviewed Original ResearchConceptsBody mass indexPCa-specific mortalityTimes higher riskProstate cancer riskFatty acid synthaseLethal PCaPCa mortalityOverweight patientsLean menOverweight menMass indexTumor expressionSingle nucleotide polymorphismsCancer riskHigh riskFASN expressionHigher body mass indexVariant allelesPCa-specific deathCase-control studyAge-matched controlsGermline single nucleotide polymorphismsCommon germline single nucleotide polymorphismsDe novo lipogenesisHomozygous variant allele
2009
Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?
Stark JR, Perner S, Stampfer MJ, Sinnott JA, Finn S, Eisenstein AS, Ma J, Fiorentino M, Kurth T, Loda M, Giovannucci EL, Rubin MA, Mucci LA. Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27: 3459-64. PMID: 19433685, PMCID: PMC2717753, DOI: 10.1200/JCO.2008.20.4669.Peer-Reviewed Original Research
2008
Testing a multigene signature of prostate cancer death in the Swedish Watchful Waiting Cohort.
Mucci LA, Pawitan Y, Demichelis F, Fall K, Stark JR, Adami HO, Andersson SO, Andrén O, Eisenstein A, Holmberg L, Huang W, Kantoff PW, Kim R, Perner S, Stampfer MJ, Johansson JE, Rubin MA. Testing a multigene signature of prostate cancer death in the Swedish Watchful Waiting Cohort. Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology 2008, 17: 1682-8. PMID: 18583469, PMCID: PMC2536630, DOI: 10.1158/1055-9965.EPI-08-0044.Peer-Reviewed Original Research