Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals
Sankar A, Ozenne B, Dam V, Svarer C, Jørgensen M, Miskowiak K, Frokjaer V, Knudsen G, Fisher P. Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals. Translational Psychiatry 2023, 13: 165. PMID: 37169780, PMCID: PMC10175268, DOI: 10.1038/s41398-023-02440-3.Peer-Reviewed Original ResearchConceptsResponses to emotional facesFunctional magnetic resonance imagingEmotional facesNeural responsesNeural responses to emotional stimuliEmotional face-matching taskNeural processing of emotionResponses to emotional stimuliPositron emission tomographyEmotional processing biasesFace-matching taskProcessing of emotionsHealthy controlsAntidepressant treatmentBrain serotonergicProcessing biasesDepressive disorderEmotional processingEmotional stimuliSerotonergic signalingMDDMatching taskBrain functionLatent variable modelsDepression statusSerotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction
Köhler-Forsberg K, Dam V, Ozenne B, Sankar A, Beliveau V, Landman E, Larsen S, Poulsen A, Ip C, Jørgensen A, Meyer M, Stenbæk D, Eiberg H, Madsen J, Svarer C, Jørgensen M, Frokjaer V, Knudsen G. Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction. JAMA Psychiatry 2023, 80: 296-304. PMID: 36753296, PMCID: PMC9909578, DOI: 10.1001/jamapsychiatry.2022.4539.Peer-Reviewed Original ResearchConceptsMemory dysfunctionUntreated MDDDepressive disorderReceptor bindingHealthy controlsModerate to severe depressive episodePositron emission tomographyMajor depressive disorderSevere depressive episodeVerbal memory performanceNeurobiological signatureDepressive episodeVerbal memoryMemory performanceCognitive domainsDepression trialsMDDDepressive stateBrain bindingCognitive testsCognitive functionGroup differencesAssociated with improved learningSerotonin-4Adult participants