2024
Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression.
Høgsted E, Beliveau V, Ozenne B, Madsen M, Svarer C, Dam V, Johansen A, Fisher P, Knudsen G, Frokjaer V, Sankar A. Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression. The British Journal Of Psychiatry 2024, 1-7. PMID: 39632615, DOI: 10.1192/bjp.2024.143.Peer-Reviewed Original ResearchFacets of neuroticismCortisol awakening responseHPA axis functionR bindingReduce neuroticismAxis functionPositron emission tomographyNEO Personality InventoryNEO-PI-RAssessment of neuroticismSerotonin 2A receptorMarkers of depressionTreatment of depressionPersonality InventoryMood symptomsAwakening responseNeuroticismPositive associationLatent variable modelsSelf-consciousnessDepressionReceptor bindingNovel interventionsPsilocybinFindings prompt considerationNeocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals
Sankar A, Ziersen S, Ozenne B, Dam V, Beaman E, Kessing L, Fisher P, Budtz-Jørgensen E, Knudsen G, Miskowiak K, Frokjaer V. Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals. Nature Mental Health 2024, 2: 1231-1238. DOI: 10.1038/s44220-024-00299-x.Peer-Reviewed Original ResearchRisk of depressionFacets of neuroticismPersonality trait neuroticismPathophysiology of depressionSerotonin 2A receptorMolecular brain imagingHigh neuroticismTrait neuroticismDepressive episodeNeuroticismDepression diagnosisHealthy individualsDepressionReceptor bindingBrain imagingDanish registersCause-specific Cox regression analysesEvaluation of clinical strategiesIndividualsCox regression analysisPsychotherapyClinical strategiesPsychedelicsSerotoninRegression analysis
2023
Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
Jensen K, Dam V, Ganz M, Fisher P, Ip C, Sankar A, Marstrand-Joergensen M, Ozenne B, Osler M, Penninx B, Pinborg L, Frokjaer V, Knudsen G, Jørgensen M. Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort. BMC Psychiatry 2023, 23: 151. PMID: 36894940, PMCID: PMC9999625, DOI: 10.1186/s12888-023-04618-x.Peer-Reviewed Original ResearchConceptsQuick Inventory of Depressive SymptomatologyFirst-episode depressionTreatment packageFirst-episode MDD patientsInventory of Depressive SymptomatologyBackgroundMajor depressive disorderSecond-line antidepressantsHeterogeneous brain disordersMarkers of treatment responseMedication side effectsMDD patientsDepressive disorderDepression severityDepressive symptomatologyPrecision psychiatrySymptom ChecklistClinical outcomesNeuroimaging dataBrain positron emission tomographyPublic outpatient clinicsDisability ScalePositron emission tomographyBrain disordersEffect of treatment choiceDepression