Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Matthews T, Rasmussen L, Ambler A, Danese A, Eugen-Olsen J, Fancourt D, Fisher H, Iversen K, Schultz M, Sugden K, Williams B, Caspi A, Moffitt T. Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood. Brain Behavior And Immunity 2023, 115: 727-736. PMID: 37992788, PMCID: PMC11194667, DOI: 10.1016/j.bbi.2023.11.022.Peer-Reviewed Original ResearchConceptsSoluble urokinase plasminogen activator receptorC-reactive proteinSystemic chronic inflammationInterleukin-6Triage StudyMedical patientsChronic inflammationAge 45Social isolationStudy participantsHigher C-reactive proteinNew inflammation markerPopulation-representative birth cohortUrokinase plasminogen activator receptorEnvironmental Risk (E-Risk) Longitudinal Twin StudyHigher median levelsPlasminogen activator receptorDunedin Longitudinal StudyElevated markersSuPAR levelsSystemic inflammationInflammation markersInflammation biomarkersGeneral populationInflammation