Modeling the Cell's Guidance System
Iglesias P, Levchenko A. Modeling the Cell's Guidance System. Science Signaling 2002, 2002: re12. PMID: 12209053, DOI: 10.1126/stke.2002.148.re12.Peer-Reviewed Original ResearchModels of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and Neutrophils
Levchenko A, Iglesias P. Models of Eukaryotic Gradient Sensing: Application to Chemotaxis of Amoebae and Neutrophils. Biophysical Journal 2002, 82: 50-63. PMID: 11751295, PMCID: PMC1302448, DOI: 10.1016/s0006-3495(02)75373-3.Peer-Reviewed Original ResearchConceptsPersistent signalingBiochemical signal transduction pathwaysSmall G proteinsChemotaxis of amoebaeSignal transduction pathwaysG protein activationEukaryotic cellsGradient sensingEukaryotic gradient sensingG proteinsCell typesSignal gradientExquisite precisionChemoattractant gradientPerfect adaptationSignalingAmoebaeActivatorPositive feedbackSensory systemsContinuous presenceAdaptationShallow gradientsChemoattractantInactivator