2022
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiological Specimen BanksBrainCOVID-19HumansMagnetic Resonance ImagingMiddle AgedSARS-CoV-2SmellUnited KingdomConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex
2020
Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans
Mathias S, Knowles E, Mollon J, Rodrigue A, Koenis M, Alexander-Bloch A, Winkler A, Olvera R, Duggirala R, Göring H, Curran J, Fox P, Almasy L, Blangero J, Glahn D. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cerebral Cortex 2020, 30: 3439-3450. PMID: 32037459, PMCID: PMC7233007, DOI: 10.1093/cercor/bhz319.Peer-Reviewed Original ResearchConceptsGeneral cognitive abilityCognitive abilitiesLocal gyrificationSuperior cognitive abilitiesCortical surface pointsNeurobiology of intelligenceCognitive testsNeuroimaging studiesNeuroanatomical variablesStructural brain imagesMinimal relationshipCortical regionsEffect sizeGyrificationPrevious studiesAbilityNeurobiologyBrain imagesIntelligenceRelationshipHumansIndividualsPotential issuesImplicationsProfound implications
2017
Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study
Sexton C, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan C, Topiwala A, Kyle S, Spiegelhalder K, Singh‐Manoux A, Kivimaki M, Mackay C, Johansen‐Berg H, Ebmeier K. Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study. Human Brain Mapping 2017, 38: 5465-5473. PMID: 28745016, PMCID: PMC5655937, DOI: 10.1002/hbm.23739.Peer-Reviewed Original ResearchConceptsWhite matter microstructurePoor sleep qualitySleep qualityPoor sleep quality groupSelf-reported sleep qualitySmall effect sizesCommunity-dwelling membersHum Brain MappDiffusion tensorRadial diffusivity valuesVoxel-wise analysisWhite matter measuresCurrent sleep qualityEffect sizeGlobal fractional anisotropyModifiable factorsLifestyle measuresSleep disturbancesPoor sleepSub studyGeneral cognitive functionNeurological illnessAxial diffusivityCognitive functionFractional anisotropy
2013
Influence of age, sex and genetic factors on the human brain
McKay DR, Knowles EE, Winkler AA, Sprooten E, Kochunov P, Olvera RL, Curran JE, Kent JW, Carless MA, Göring HH, Dyer TD, Duggirala R, Almasy L, Fox PT, Blangero J, Glahn DC. Influence of age, sex and genetic factors on the human brain. Brain Imaging And Behavior 2013, 8: 143-152. PMID: 24297733, PMCID: PMC4011973, DOI: 10.1007/s11682-013-9277-5.Peer-Reviewed Original ResearchGenetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging
Glahn DC, Kent JW, Sprooten E, Diego VP, Winkler AM, Curran JE, McKay DR, Knowles EE, Carless MA, Göring HH, Dyer TD, Olvera RL, Fox PT, Almasy L, Charlesworth J, Kochunov P, Duggirala R, Blangero J. Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 19006-19011. PMID: 24191011, PMCID: PMC3839730, DOI: 10.1073/pnas.1313735110.Peer-Reviewed Original ResearchTranscriptomics of cortical gray matter thickness decline during normal aging
Kochunov P, Charlesworth J, Winkler A, Hong LE, Nichols TE, Curran JE, Sprooten E, Jahanshad N, Thompson PM, Johnson MP, Kent JW, Landman BA, Mitchell B, Cole SA, Dyer TD, Moses EK, Goring HH, Almasy L, Duggirala R, Olvera RL, Glahn DC, Blangero J. Transcriptomics of cortical gray matter thickness decline during normal aging. NeuroImage 2013, 82: 273-283. PMID: 23707588, PMCID: PMC3759649, DOI: 10.1016/j.neuroimage.2013.05.066.Peer-Reviewed Original ResearchConceptsPathway enrichment analysisTranscriptome dataInnate immune pathwaysEnrichment analysisCellular proliferationInnate immune response pathwaysImmune pathwaysImmune response pathwaysResponse pathwaysFunctional categoriesPathway enrichmentTranscriptional activityGenesExpression activityTranscriptsHigh-resolution T1-weighted MRINormal cerebral agingCommunity-dwelling membersPathwaySignificance thresholdRegenerative capacityT1-weighted MRIDifferentiationCerebral agingViral infection
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insights
2010
Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure
Kochunov P, Glahn D, Lancaster J, Winkler A, Kent JW, Olvera RL, Cole SA, Dyer TD, Almasy L, Duggirala R, Fox PT, Blangero J. Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure. Stroke 2010, 41: 2137-2142. PMID: 20724716, PMCID: PMC3084627, DOI: 10.1161/strokeaha.110.590943.Peer-Reviewed Original ResearchA Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore componentGenetics of microstructure of cerebral white matter using diffusion tensor imaging
Kochunov P, Glahn DC, Lancaster JL, Winkler AM, Smith S, Thompson PM, Almasy L, Duggirala R, Fox PT, Blangero J. Genetics of microstructure of cerebral white matter using diffusion tensor imaging. NeuroImage 2010, 53: 1109-1116. PMID: 20117221, PMCID: PMC2888778, DOI: 10.1016/j.neuroimage.2010.01.078.Peer-Reviewed Original Research
2009
Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies
Winkler AM, Kochunov P, Blangero J, Almasy L, Zilles K, Fox PT, Duggirala R, Glahn DC. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. NeuroImage 2009, 53: 1135-1146. PMID: 20006715, PMCID: PMC2891595, DOI: 10.1016/j.neuroimage.2009.12.028.Peer-Reviewed Original ResearchAnalysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume
Kochunov P, Glahn D, Winkler A, Duggirala R, Olvera RL, Cole S, Dyer TD, Almasy L, Fox PT, Blangero J. Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume. Stroke 2009, 40: 3685-3690. PMID: 19834011, PMCID: PMC2787844, DOI: 10.1161/strokeaha.109.565390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingBiomarkersBrain IschemiaCerebrospinal Fluid PressureCerebrumChromosome MappingCohort StudiesDisease ProgressionDNA Mutational AnalysisEpendymaFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic TestingGenetic VariationHumansIntracranial HypertensionLeukoencephalopathiesMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNerve Fibers, MyelinatedYoung AdultConceptsArterial pulse pressurePulse pressureImportant neuroimaging markerFluid-attenuated inversion recovery imagesCommon risk factorsWhite matter volumeYears of ageInversion recovery imagesHealthy Mexican AmericansHWM volumeFamily Heart StudyRisk factorsCerebral volumeNeuroimaging markerHeart StudyMatter volumeWhite matterWhole brainPathophysiology studiesCerebral integritySan Antonio Family Heart StudyRecovery imagesMexican AmericansWhole-genome linkageGenome linkage
2005
Tendência da mortalidade por doenças isquêmicas do coração na cidade de Curitiba - Brasil, de 1980 a 1998
Daniel E, Germiniani H, Nazareno E, Braga S, Winkler A, Cunha C. Tendência da mortalidade por doenças isquêmicas do coração na cidade de Curitiba - Brasil, de 1980 a 1998. Arquivos Brasileiros De Cardiologia 2005, 85: 100-104. PMID: 16113847, DOI: 10.1590/s0066-782x2005001500005.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseAcute myocardial infarctionYears of ageMyocardial infarctionHeart diseaseAge rangeMortality rateData of deathMale sexIschemic diseasesMinistério da SaúdeInfarctionMortality trendsDiseaseGreater decreaseSexAgeTrend of reductionCity of CuritibaPopulation dataYearsSignificance levelPopulation of CuritibaLinear regressionMortalidade