2016
Cognitive Phenotypes and Endophenotypes: Concepts and Criteria
Bearden C, Winkler A, Karlsgodt K, Bilder R. Cognitive Phenotypes and Endophenotypes: Concepts and Criteria. Innovations In Cognitive Neuroscience 2016, 61-80. DOI: 10.1007/978-1-4614-3846-5_4.Peer-Reviewed Original ResearchCategorical disease phenotypesGenetic mapping studiesDirect drug targetComplex traitsQuantitative traitsDrug targetsPhenotype approachNew phenotypesComplex diseasesSpecific molecular targetsDisease phenotypePhenotypeMolecular targetsNeuropsychiatric TherapeuticsMapping studiesBiological mechanismsCognitive phenotypesNeuroanatomic phenotypesTraitsBiological validityQuantitative assayDiagnostic phenotypesNeural systems levelDramatic advancesHeritability
2011
High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. High Dimensional Endophenotype Ranking in the Search for Major Depression Risk Genes. Biological Psychiatry 2011, 71: 6-14. PMID: 21982424, PMCID: PMC3230692, DOI: 10.1016/j.biopsych.2011.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChromosomes, Human, Pair 4Cognition DisordersDepressive Disorder, MajorEndophenotypesFamily HealthFemaleGene Expression ProfilingGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMagnetic Resonance ImagingMaleMexican AmericansMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPsychiatric Status Rating ScalesQuantitative Trait LociRiskYoung AdultConceptsGenome-wide significant quantitative trait lociSignificant quantitative trait lociQuantitative trait lociGenome-wide significanceBivariate linkage analysisGenetic utilityTrait lociCausal genesDepression genesLinkage analysisRisk genesPleiotropic effectsExtended pedigreesGenesMexican-American individualsObjective endophenotypesExpression levelsUnrelated individualsFamily-based studyIntermediate phenotypesBiological mechanismsUnbiased methodLociTraitsNew insights