Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans
Abend R, Burk D, Ruiz S, Gold A, Napoli J, Britton J, Michalska K, Shechner T, Winkler A, Leibenluft E, Pine D, Averbeck B. Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans. ELife 2022, 11: e66169. PMID: 35473766, PMCID: PMC9197395, DOI: 10.7554/elife.66169.Peer-Reviewed Original ResearchConceptsThreat learningAnxiety severitySafety learningNeuroanatomical substratesGreater anxiety severitySkin conductance dataThreat conditioningThreat extinctionThreat generalizationGray matter volumeSafe stimuliAssociative learningComputational mechanismsAnxiety symptomsAnxiety disordersInfluential theoriesSlower extinctionComputational modelLearningWhole brain anatomyAnxietyComputational modelingStructural imagingStimuliTaskBrain morphology in juvenile anxiety disorders: transdiagnostic examinations using big data and machine learning
Bruin W, Zhutovsky P, van Wingen G, Thomas R, Bas-Hoogendam J, Groenewold N, Hilbert K, Lueken U, Thompson P, Winkler A, Zugman A, Pine D, van der Wee N, Stein D, Veltman D, Aghajani M. Brain morphology in juvenile anxiety disorders: transdiagnostic examinations using big data and machine learning. Neuroscience Applied 2022, 1: 100141. DOI: 10.1016/j.nsa.2022.100141.Peer-Reviewed Original Research