2015
Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia
Wright S, Hong L, Winkler A, Chiappelli J, Nugent K, Muellerklein F, Du X, Rowland L, Wang D, Kochunov P. Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia. Human Brain Mapping 2015, 36: 3793-3804. PMID: 26108347, PMCID: PMC4714540, DOI: 10.1002/hbm.22878.Peer-Reviewed Original ResearchConceptsWM integrityDiffusion tensor imagingArterial spin labelingPatient-control differencesPS deficitsReduced WM integrityPerfusion shiftCerebral information processingLower WM integrityCerebral WMNeurophysiological alterationsInformation processing speedSchizophrenia patientsGray matterCognitive deficitsTensor imagingBlood perfusionSchizophreniaDeficitsFurther examinationSpin labelingProcessing speedPatientsCohortPerfusion
2012
Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression
Kochunov P, Glahn DC, Rowland LM, Olvera RL, Winkler A, Yang YH, Sampath H, Carpenter WT, Duggirala R, Curran J, Blangero J, Hong LE. Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression. Biological Psychiatry 2012, 73: 482-491. PMID: 23200529, PMCID: PMC3645491, DOI: 10.1016/j.biopsych.2012.10.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMDD cohortAge-related declineFractional anisotropyWM tractsFA valuesAge interactionMain outcome measuresCerebral white matterPathophysiology of schizophreniaAverage fractional anisotropyWhite matter integrityCerebral WMMajor WM tractsMDD patientsDepressive disorderMajor depressionOutcome measuresFunctional declineSCZ patientsWhite matterCohortPeak myelinationPatientsWM FA values