2011
THE ROUTES OF ERK ACTIVATION IN PROLACTIN‐STIMULATED BREAST CANCER CELLS
Aksamitiene E, Achanta S, Kiyatkin A, Hoek J. THE ROUTES OF ERK ACTIVATION IN PROLACTIN‐STIMULATED BREAST CANCER CELLS. The FASEB Journal 2011, 25: 946.1-946.1. DOI: 10.1096/fasebj.25.1_supplement.946.1.Peer-Reviewed Original ResearchJanus kinase/signal transducerDistinct signal transduction pathwaysRac/PAK pathwayBreast cancer cellsKinase/signal transducerRas/mitogenSignal transduction pathwaysActivator of transcriptionKinase/AktTotal cell lysatesActivity of JAK2Cancer cellsPI3K/AktAdaptor proteinShc familyPAK pathwaySrc familyProtein kinaseTransduction pathwaysTyrosine phosphorylationC-RafPhosphoinositide 3Cancer cell proliferationSignal transducerMAPK signaling
2006
Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*
Kiyatkin A, Aksamitiene E, Markevich NI, Borisov NM, Hoek JB, Kholodenko BN. Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*. Journal Of Biological Chemistry 2006, 281: 19925-19938. PMID: 16687399, PMCID: PMC2312093, DOI: 10.1074/jbc.m600482200.Peer-Reviewed Original ResearchConceptsEpidermal growth factorRas/MAPK signalingGab1 tyrosine phosphorylationGrowth factorRole of Gab1PI3K/Akt activationMultiple positive feedback loopsProtein Grb2Mutant proteinsScaffold proteinTyrosine phosphorylationBinder 1Positive feedback loopMitogenic pathwaysMAPK signalingEssential functionsSurvival signalingDiverse perturbationsCellular responsesAkt activationCytokine receptorsPharmacological inhibitorsGab1EGF dosesGrb2