2016
Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation
Massart R, Nemoda Z, Suderman MJ, Sutti S, Ruggiero AM, Dettmer AM, Suomi SJ, Szyf M. Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation. Development And Psychopathology 2016, 28: 1259-1272. PMID: 27687908, PMCID: PMC6590057, DOI: 10.1017/s0954579416000833.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNA MethylationEpigenesis, GeneticFemaleHumansLife Change EventsMacaca mulattaMaleMaternal DeprivationPhenotypeSex FactorsStress, PsychologicalConceptsDNA methylation profilesDNA methylation changesMethylation profilesMethylation changesGenome-wide DNA methylation changesEpigenetic programsDevelopmental evolutionEpigenetic processesDNA methylationAdult phenotypeDevelopmental dynamicsNormal evolutionGenesMethylationEvolutionPhenotypeEarly life eventsEarly life experiencesEffects of sexFemalesEarly life adversityT lymphocytesNonhuman primatesRodentsPrimatesAssociations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys
Dettmer AM, Wooddell LJ, Rosenberg KL, Kaburu SS, Novak MA, Meyer JS, Suomi SJ. Associations between early life experience, chronic HPA axis activity, and adult social rank in rhesus monkeys. Social Neuroscience 2016, 12: 92-101. PMID: 27063359, PMCID: PMC6528805, DOI: 10.1080/17470919.2016.1176952.Peer-Reviewed Original ResearchConceptsChronic HPA axis activityHair cortisol concentrationsHPA axis activityHealth outcomesEarly life experiencesAxis activityAxis regulationRhesus monkeysNeuroendocrine stress regulationSocioeconomic statusHPA axis regulationAdrenal axis regulationAdverse health outcomesFemale rhesus monkeysEarly life adversityRisk factorsAdult social statusNR monkeysCortisol concentrationsLife adversityMonkeysOutcomesEarly experienceMonthsLife experiences
2014
Population density-dependent hair cortisol concentrations in rhesus monkeys (Macaca mulatta)
Dettmer AM, Novak MA, Meyer JS, Suomi SJ. Population density-dependent hair cortisol concentrations in rhesus monkeys (Macaca mulatta). Psychoneuroendocrinology 2014, 42: 59-67. PMID: 24636502, PMCID: PMC3959662, DOI: 10.1016/j.psyneuen.2014.01.002.Peer-Reviewed Original ResearchConceptsHair cortisol concentrationsHD monkeysAxis activityCortisol concentrationsChronic HPA axis activityChronic stressRhesus monkeysHigher hair cortisolAdrenal axis activityHPA axis activityFight woundsGlucocorticoid exposureGlucocorticoids resultsAcute measuresHealth disparitiesHair cortisolNonhuman primate speciesElevated levelsAge categoriesMonkeysHuman epidemiologyPopulation levelExposureReliable indicatorHumans
2011
Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses
Dettmer AM, Novak MA, Suomi SJ, Meyer JS. Physiological and behavioral adaptation to relocation stress in differentially reared rhesus monkeys: Hair cortisol as a biomarker for anxiety-related responses. Psychoneuroendocrinology 2011, 37: 191-199. PMID: 21715101, PMCID: PMC3196800, DOI: 10.1016/j.psyneuen.2011.06.003.Peer-Reviewed Original ResearchConceptsMonths of ageHair cortisolCortisol levelsAnxiety scoresMonth 6Anxious behaviorInfant monkeysMonths of lifeYears of ageElevated hair cortisolEarly life adversityElevated cortisol levelsAnxiety-related responsesRhesus monkey infantsHigher cortisol levelsHair cortisol concentrationsRapid physiological adaptationsMPR groupStress-related health problemsMonth 8PR groupSPR groupMajor life stressorsDay 14Cortisol concentrations
2010
Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis
Herod SM, Dettmer AM, Novak MA, Meyer JS, Cameron JL. Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis. AJP Endocrinology And Metabolism 2010, 300: e28-e36. PMID: 20959528, PMCID: PMC3023200, DOI: 10.1152/ajpendo.00223.2010.Peer-Reviewed Original ResearchConceptsStress-induced reproductive dysfunctionHPA axis activityReproductive dysfunctionAxis activityHSR monkeysSS monkeysBaseline HPA axis activityChronic HPA axis activityAdrenal axis activityMetabolic stressFemale cynomolgus monkeysAcute psychological stressConcentrations of cortisolEveryday life stressDiurnal releaseAdrenal axisAdrenal weightHPA axisCommon causeCynomolgus monkeysPercent suppressionDysfunctionCortisolACTHPsychological stress