2024
Systematic review: The use of large language models as medical chatbots in digestive diseases
Giuffrè M, Kresevic S, You K, Dupont J, Huebner J, Grimshaw A, Shung D. Systematic review: The use of large language models as medical chatbots in digestive diseases. Alimentary Pharmacology & Therapeutics 2024, 60: 144-166. PMID: 38798194, DOI: 10.1111/apt.18058.Peer-Reviewed Original ResearchLanguage modelAdverse patient safety eventsPatient safety eventsClinical decision supportRisk of biasSystematic literature searchWeb of Science Core CollectionCombination of keywordsMedical chatbotTriage recommendationsHealthcare systemScience Core CollectionNecessary careSafety eventsOverburden healthcare systemsMedical adviceOvid MEDLINEMultiple specialtiesDecision supportOvid EmbaseCochrane LibrarySingle-study resultsGoogle ScholarLiterature searchGastroenterologyDyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocol
Choy C, McAdow M, Rosenberg J, Grimshaw A, Martinez-Brockman J. Dyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocol. PLOS ONE 2024, 19: e0298927. PMID: 38625992, PMCID: PMC11020692, DOI: 10.1371/journal.pone.0298927.Peer-Reviewed Original ResearchConceptsCare interventionsBirthing personsHealth outcomesCare studiesJoanna Briggs Institute critical appraisal toolsPostnatal health outcomesReduce healthcare disparitiesImprove healthcare deliveryProvision of careCritical appraisal toolsWHO regional databasesRisk of biasOpen Science FrameworkObstetric careHealthcare disparitiesImplementation outcomesNarrative synthesisAppraisal ToolImprove disparitiesHealthcare deliveryGrey literaturePractice gapReview protocolWeb of Science Core CollectionHealthcare system
2022
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesRandomized Clinical Trials of Machine Learning Interventions in Health Care
Plana D, Shung DL, Grimshaw AA, Saraf A, Sung JJY, Kann BH. Randomized Clinical Trials of Machine Learning Interventions in Health Care. JAMA Network Open 2022, 5: e2233946. PMID: 36173632, PMCID: PMC9523495, DOI: 10.1001/jamanetworkopen.2022.33946.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsRisk of biasClinical trialsSystematic reviewNon-RCT designHealth careCONSORT-AIClinical adoptionCochrane riskOvid EmbaseCochrane LibraryTrial characteristicsOvid MEDLINEPrimary interventionExclusion criteriaCommon reasonMedian proportionPatient careRCT designLiterature searchOverall riskRelevant articlesLack of participantsTrialsGoogle Scholar
2021
Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis
Holleck JL, Roberts AE, Marhoffer EA, Grimshaw AA, Gunderson CG. Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta‐analysis. Journal Of Hospital Medicine 2021, 16: 489-494. PMID: 34328838, DOI: 10.12788/jhm.3655.Peer-Reviewed Original ResearchConceptsSevere gastrointestinal side effectsGastrointestinal side effectsIntestinal necrosisHazard ratioSide effectsComposite outcomeOdds ratioSodium polystyrene sulfonateSystematic reviewSevere gastrointestinal adverse eventsGastrointestinal adverse eventsPooled hazard ratioRisk of biasPooled odds ratioCase-control studyPrior systematic reviewsSystematic literature searchAdverse eventsAlternative medicationsCochrane LibraryDatabase inceptionClinical trialsNecrosis rateInclusion criteriaPotential confounding
2020
Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review
Arora T, Martin M, Grimshaw A, Mansour S, Wilson FP. Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review. BMJ Open 2020, 10: e042035. PMID: 33371041, PMCID: PMC7757434, DOI: 10.1136/bmjopen-2020-042035.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPrediction of outcomeSystematic reviewKidney injuryOutcomes of AKIResolution of AKIProgression of AKILong-term outcomesBias assessment toolRisk of biasMultivariable predictive modelMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsFull-text reviewPrediction model RiskAKI careCohort studyNegative long-term outcomesThird reviewerReporting ItemsAbstract screeningComprehensive searchPatientsCommon diseaseData extractionPrevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis
Gunderson CG, Bilan VP, Holleck JL, Nickerson P, Cherry BM, Chui P, Bastian LA, Grimshaw AA, Rodwin BA. Prevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis. BMJ Quality & Safety 2020, 29: 1008-1018. PMID: 32269070, DOI: 10.1136/bmjqs-2019-010822.Peer-Reviewed Original ResearchConceptsAdverse eventsDiagnostic errorsPhysician reviewSystematic reviewInpatient adverse eventsRisk of biasPatient safety hazardsSystem-related factorsSystematic literature searchWeb of SciencePulmonary embolismAdult patientsCase seriesCommon diagnosisPooled rateAdult admissionsCochrane LibraryDatabase inceptionDiagnostic error rateStudy characteristicsLiterature searchPatientsCommon diseaseDiagnosisCommon being
2019
Evaluation of Efficacy and Safety of Front-Line Regimens for the Treatment of Transplant Ineligible Patients with Multiple Myeloma: A Network Meta-Analysis of Phase 2/3 Randomized Controlled Trials
Giri S, Aryal M, Yu H, Grimshaw A, Pathak R, Huntington S, Dhakal B. Evaluation of Efficacy and Safety of Front-Line Regimens for the Treatment of Transplant Ineligible Patients with Multiple Myeloma: A Network Meta-Analysis of Phase 2/3 Randomized Controlled Trials. Blood 2019, 134: 2188. DOI: 10.1182/blood-2019-130389.Peer-Reviewed Original ResearchProgression-free survivalOverall response rateHematopoietic cell transplantFront-line treatmentAdverse eventsOverall survivalMM patientsMultiple myelomaFrontline regimensClinical trialsAdvisory CommitteeCommon grade 3Cumulative ranking (SUCRA) probabilitiesFront-line regimensHigher adverse eventsPrimary efficacy outcomeTransplant-ineligible patientsPhase III RCTsNetwork Meta-AnalysisBias assessment toolRisk of biasEvaluation of efficacyIndividual patient needsEfficacious regimenEfficacious regimens