2023
Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients
Vaca F, Dziura J, Abujarad F, Pantalon M, Hsiao A, Reynolds J, Maciejewski K, Field C, D’Onofrio G. Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients. JAMA Network Open 2023, 6: e2314848. PMID: 37219901, PMCID: PMC10208138, DOI: 10.1001/jamanetworkopen.2023.14848.Peer-Reviewed Original ResearchConceptsStandard care groupNumber of bingesEmergency department patientsStandard careED patientsCare groupBrief interventionDepartment patientsAlcohol screeningDisease burdenUnhealthy drinkingDigital health toolsLevel II trauma centerHealth toolsParticipants 25 yearsAlcohol-related health disparitiesTertiary care centerAdverse health behaviorsUnhealthy alcohol useHigh disease burdenAlcohol use disorderTimeline followback methodEmergency medical careSelf-reported numberHigh-risk drinking
2022
Alerting Clinicians to 1-Year Mortality Risk in Patients Hospitalized With Heart Failure
Ahmad T, Desai NR, Yamamoto Y, Biswas A, Ghazi L, Martin M, Simonov M, Dhar R, Hsiao A, Kashyap N, Allen L, Velazquez EJ, Wilson FP. Alerting Clinicians to 1-Year Mortality Risk in Patients Hospitalized With Heart Failure. JAMA Cardiology 2022, 7: 905-912. PMID: 35947362, PMCID: PMC9366654, DOI: 10.1001/jamacardio.2022.2496.Peer-Reviewed Original ResearchConceptsUsual care groupElectronic health recordsHeart failureAlert groupMedian agePrimary outcomeFemale patientsTerminal pro-brain natriuretic peptide levelsYale New Haven Health SystemPro-brain natriuretic peptide levelsMedian NT-proBNP levelLeft ventricular ejection fractionLarge tertiary care centerHeart failure hospitalizationHeart failure medicationsNatriuretic peptide levelsNT-proBNP levelsHealth recordsHours of admissionTertiary care centerVentricular ejection fractionRate of hospitalizationIntensive care unitEthnicity groupsSmall community hospital
2021
Disparities in Accessing and Reading Open Notes in the Emergency Department Upon Implementation of the 21st Century CURES Act
Sangal RB, Powers E, Rothenberg C, Ndumele C, Ulrich A, Hsiao A, Venkatesh AK. Disparities in Accessing and Reading Open Notes in the Emergency Department Upon Implementation of the 21st Century CURES Act. Annals Of Emergency Medicine 2021, 78: 593-598. PMID: 34353651, DOI: 10.1016/j.annemergmed.2021.06.014.Peer-Reviewed Original ResearchConceptsProportion of patientsPatient portal accessEmergency departmentOpen notesClinical notesPortal accessPublic insuranceUrgent care centersCentury Cures ActDifferent patient demographicsSingle health systemPatient demographicsPrimary outcomeCures ActPatient utilizationPatient visitsCare centerObservational studyPatientsDigital health toolsAge 18Health systemHealth toolsUnique barriersNon-English speakersClinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient populationEarly identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules
Shung D, Tsay C, Laine L, Chang D, Li F, Thomas P, Partridge C, Simonov M, Hsiao A, Tay JK, Taylor A. Early identification of patients with acute gastrointestinal bleeding using natural language processing and decision rules. Journal Of Gastroenterology And Hepatology 2021, 36: 1590-1597. PMID: 33105045, DOI: 10.1111/jgh.15313.Peer-Reviewed Original ResearchConceptsNatural language processingElectronic health recordsLanguage processingNLP algorithmSystematized NomenclatureReal timeAcute gastrointestinal bleedingBidirectional Encoder RepresentationsDecision rulesEHR-based phenotyping algorithmsGastrointestinal bleedingRisk stratification scoresEncoder RepresentationsData elementsPhenotyping algorithmStratification scoresHealth recordsAlgorithmPhenotyping of patientsEmergency department patientsTime of presentationRisk stratification modelED reviewDeploymentExternal validation
2020
COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system
Caraballo C, McCullough M, Fuery MA, Chouairi F, Keating C, Ravindra NG, Miller PE, Malinis M, Kashyap N, Hsiao A, Wilson FP, Curtis JP, Grant M, Velazquez EJ, Desai NR, Ahmad T. COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system. PLOS ONE 2020, 15: e0238829. PMID: 32997657, PMCID: PMC7526909, DOI: 10.1371/journal.pone.0238829.Peer-Reviewed Original ResearchConceptsHeart failure patientsIntegrated health care systemHeart Failure RegistryHealth care systemFailure patientsCOVID-19 infectionCare systemCOVID-19SARS-CoV-2 infectionReal-time registryRenin-angiotensin blockersRetrospective chart reviewCoronary artery diseaseRisk of deathCOVID-19 testingAngiotensin blockersMultiple comorbiditiesRespiratory failureChart reviewSymptomatic patientsArtery diseaseHeart failureComorbid conditionsPatient mortalityClinical management
2019
A randomized trial of decision support for tobacco dependence treatment in an inpatient electronic medical record: clinical results
Bernstein SL, Weiss J, DeWitt M, Tetrault JM, Hsiao AL, Dziura J, Sussman S, Miller T, Carpenter K, O’Connor P, Toll B. A randomized trial of decision support for tobacco dependence treatment in an inpatient electronic medical record: clinical results. Implementation Science 2019, 14: 8. PMID: 30670043, PMCID: PMC6343239, DOI: 10.1186/s13012-019-0856-8.Peer-Reviewed Original ResearchConceptsPatient's primary care providerPrimary care providersTobacco treatment medicationsElectronic health recordsTobacco use disorderQuit ratesTreatment medicationsProblem listCare providersUse disordersOne-year quit ratesState tobacco quitlineTobacco quit ratesPrescription of medicationsTobacco dependence treatmentProcess of careSingle hospital systemElectronic medical recordsInpatient electronic medical recordPatient's problem listSustained quittingAdult patientsControl patientsCurrent smokingHospitalized smokers
2017
“What do you know?”——knowledge among village doctors of lead poisoning in children in rural China
Huang R, Ning H, Baum CR, Chen L, Hsiao A. “What do you know?”——knowledge among village doctors of lead poisoning in children in rural China. BMC Public Health 2017, 17: 895. PMID: 29169343, PMCID: PMC5701361, DOI: 10.1186/s12889-017-4895-2.Peer-Reviewed Original ResearchConceptsVillage doctorsLead poisoningResultsA totalMultifaceted interventionsBackgroundThis studyPrevention strategiesCollege-level educationConclusionsThis studyLevel educationPoor knowledgeRural childrenPrevention measuresChildrenDoctorsQuestionnaire-based surveyPoisoningRural ChinaRural populationTest questionnaireClear needQuestionnaireAnnual incomeMethodsADevelopment and validation of a continuously age-adjusted measure of patient condition for hospitalized children using the electronic medical record
Rothman MJ, Tepas JJ, Nowalk AJ, Levin JE, Rimar JM, Marchetti A, Hsiao AL. Development and validation of a continuously age-adjusted measure of patient condition for hospitalized children using the electronic medical record. Journal Of Biomedical Informatics 2017, 66: 180-193. PMID: 28057565, DOI: 10.1016/j.jbi.2016.12.013.Peer-Reviewed Original ResearchConceptsUnplanned ICU transfersPediatric Rothman IndexElectronic medical recordsRothman IndexICU transferPediatric RiskClinical statusPediatric hospitalHospitalized childrenMedical recordsPRI scoresPatient's conditionMortality dataPost-discharge mortalityPatient's clinical statusMortality odds ratioHospital mortalityInpatient visitsPatient ageAdult mortality dataClinical variablesOdds ratioClinical dataPhysiologic deteriorationPatient acuity
2016
Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED
Whitney RE, Santucci K, Hsiao A, Chen L. Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED. The American Journal Of Emergency Medicine 2016, 34: 1573-1575. PMID: 27289438, DOI: 10.1016/j.ajem.2016.05.075.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisPediatric emergency department (ED) visitsPOC testingEmergency department visitsLength of stayCost of admissionRandomized control trialChemistry testingCost-effective analysisDecision analysis modelCare testingDepartment visitsPediatric EDElectrolyte testingAdmission ratesSerum testingClinical assessmentControl trialMean savingsDegree of dehydrationPatientsCost savingsChildrenTrialsPayers
2010
Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis
Chen L, Hsiao A, Langhan M, Riera A, Santucci KA. Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis. Academic Emergency Medicine 2010, 17: 1042-1047. PMID: 21040104, PMCID: PMC3058669, DOI: 10.1111/j.1553-2712.2010.00873.x.Peer-Reviewed Original ResearchMeSH KeywordsAortaChildChild, PreschoolCohort StudiesDehydrationDiarrheaEmergency Service, HospitalFemaleFluid TherapyGastroenteritisHemodynamicsHumansInfantInfusions, IntravenousLinear ModelsMaleObserver VariationPilot ProjectsPoint-of-Care SystemsProspective StudiesReproducibility of ResultsSeverity of Illness IndexUltrasonography, DopplerVena Cava, InferiorConceptsInferior vena cavaIVC/Ao ratioPediatric emergency departmentAo diametersAcute gastroenteritisAo ratioBedside ultrasound measurementAcute weight lossProspective observational studyResolution of symptomsAorta diameter ratioAcute care settingInterrater reliabilityPairs of investigatorsPearson correlation coefficientSignificant dehydrationGood interrater reliabilityEmergency departmentIntravascular volumeBedside USVena cavaBedside ultrasoundObservational studyCare settingsProspective identification
2009
Changing Referral Trends of Acute Pancreatitis in Children: A 12‐year Single‐center Analysis
Park A, Latif SU, Shah AU, Tian J, Werlin S, Hsiao A, Pashankar D, Bhandari V, Nagar A, Husain SZ. Changing Referral Trends of Acute Pancreatitis in Children: A 12‐year Single‐center Analysis. Journal Of Pediatric Gastroenterology And Nutrition 2009, 49: 316-322. PMID: 19503003, PMCID: PMC3034387, DOI: 10.1097/mpg.0b013e31818d7db3.Peer-Reviewed Original ResearchConceptsTertiary care centerBody mass indexCases of pancreatitisAcute pancreatitisCare centerInclusion criteriaSingle tertiary care centerAcute pancreatitis casesPainful inflammatory disordersPediatric emergency departmentICD-9 codesPediatric pancreatitisPancreatitis casesCommon etiologyMass indexPediatric populationBiliary diseaseRecurrence rateRetrospective studyEmergency departmentInflammatory disordersMean agePediatric studiesReferral trendsPancreatitis
2007
A Randomized Trial to Assess the Efficacy of Point-of-Care Testing in Decreasing Length of Stay in a Pediatric Emergency Department
Hsiao AL, Santucci KA, Dziura J, Baker MD. A Randomized Trial to Assess the Efficacy of Point-of-Care Testing in Decreasing Length of Stay in a Pediatric Emergency Department. Pediatric Emergency Care 2007, 23: 457-462. PMID: 17666926, DOI: 10.1097/01.pec.0000280506.44924.de.Peer-Reviewed Original ResearchConceptsPediatric emergency departmentLength of stayEmergency departmentPOC groupTertiary hospital emergency departmentDedicated research assistantsFirst physician contactTrial of patientsPatient flowSelect pediatric patientsHospital emergency departmentCare testingEfficacy of pointMedical management decisionsPhysician contactPediatric patientsBlood workRandomized trialsED settingBlood drawPatientsInformed consentStayPOC testingSignificant decrease
2006
Incidence and Predictors of Serious Bacterial Infections Among 57- to 180-Day-Old Infants
Hsiao AL, Chen L, Baker MD. Incidence and Predictors of Serious Bacterial Infections Among 57- to 180-Day-Old Infants. Pediatrics 2006, 117: 1695-1701. PMID: 16651326, DOI: 10.1542/peds.2005-1673.Peer-Reviewed Original ResearchConceptsSerious bacterial illnessWhite blood cell countDirect fluorescent antibodyBlood cell countPositive direct fluorescent antibodyCell countOlder infantsEtiology of feverHeight of feverOlder febrile infantsSerious bacterial infectionsRespiratory syncytial virusMonths of ageFebrile infantsPneumococcal diseaseBacterial meningitisVaccine eraRespiratory virusesProspective studySyncytial virusLumbar punctureUrine testsBacterial illnessNasal swabsFever
2005
Pediatric Fatality Following Ingestion of Dinitrophenol: Postmortem Identification of a "Dietary Supplement"
Hsiao A, Santucci K, Seo-Mayer P, Mariappan MR, Hodsdon M, Banasiak K, Baum C. Pediatric Fatality Following Ingestion of Dinitrophenol: Postmortem Identification of a "Dietary Supplement". Clinical Toxicology 2005, 43: 281-285. DOI: 10.1081/clt-200058946.Peer-Reviewed Original ResearchUtility of Bedside Bladder Ultrasound Before Urethral Catheterization in Young Children
Chen L, Hsiao AL, Moore CL, Dziura JD, Santucci KA. Utility of Bedside Bladder Ultrasound Before Urethral Catheterization in Young Children. Pediatrics 2005, 115: 108-111. PMID: 15629989, DOI: 10.1542/peds.2004-0738.Peer-Reviewed Original ResearchConceptsPediatric emergency medicine physiciansAmount of urineUrethral catheterizationEmergency medicine physiciansBedside ultrasoundSufficient urineMedicine physiciansUrban pediatric emergency departmentIntervention phasePediatric emergency departmentPediatric emergency physiciansSuccess rateObservation phaseSimple noninvasive procedureSubsequent ultrasoundBladder ultrasoundFirst catheterizationUnsuccessful proceduresUrine cultureEmergency departmentIntervention periodInvasive testingEmergency physiciansCatheterizationUncomfortable procedure