2023
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomics
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucose
2021
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants
Galderisi A, Trevisanuto D, Russo C, Hall R, Bruschettini M. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. 2021, 2021: cd013309. PMID: 34931697, PMCID: PMC8690212, DOI: 10.1002/14651858.cd013309.pub3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRisk of hypoglycaemiaUse of CGMContinuous glucose monitoringPreterm infantsIntermittent modalitiesRisk ratioEffects of CGMLong-term neurodevelopmental impairmentGlucose monitoringEfficacy of CGMCare Group (EPOC) criteriaPreterm infants 1Cochrane Effective PracticePrevention of morbidityClinical trials databasesLong-term outcomesConfidence intervalsPreterm infant mortalitySafety of CGMImprecision of estimatesFixed-effects modelAdverse neurodevelopmentGRADE approachNeurodevelopmental outcomesDATA COLLECTION
2020
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants
Galderisi A, Bruschettini M, Russo C, Hall R, Trevisanuto D. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. 2020, 12: cd013309. PMID: 33348448, PMCID: PMC8092644, DOI: 10.1002/14651858.cd013309.pub2.Peer-Reviewed Original ResearchConceptsPreterm infantsContinuous glucose monitoringGlycemic measuresRisk ratioIntermittent modalitiesLong-term neurodevelopmental impairmentGlucose monitoringCare Group (EPOC) criteriaCochrane Central RegisterCochrane Effective PracticePrevention of morbidityQuasi-randomized trialStandard search strategyClinical trials databasesLong-term outcomesPreterm infant mortalityAllied Health LiteratureUse of CGMImprecision of estimatesFixed-effects modelCochrane NeonatalAdverse neurodevelopmentCentral RegisterGRADE approachControlled Trials
2016
The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulin
Del Rizzo M, Galderisi A, Celato A, Furlan F, Giordano L, Cazzorla C, Fasan I, Moretti C, Zschocke J, Burlina A. The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulin. European Journal Of Pediatrics 2016, 175: 1123-1128. PMID: 26847429, DOI: 10.1007/s00431-016-2699-5.Peer-Reviewed Case Reports and Technical NotesConceptsType 1 diabetes mellitusGlutaric aciduria type 1Diabetes mellitusType 1Metabolic disordersInsulin daily doseIrreversible neuronal damageLong-term treatmentSimilar pathogenic mechanismsDifferent metabolic disordersBilateral striatal necrosisMonths of ageEffect of insulinAcute hypotoniaClassical T1DMLimb dystoniaNeurological outcomeInfective episodesNeuronal injuryDaily doseNeuronal damageDystonic movementsHypoglycemic episodesCarnitine supplementationGlycemic profile
2014
An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR)
Vichi M, Iafusco D, Galderisi A, Stazi M, Nisticò L. An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR). Acta Diabetologica 2014, 51: 287-294. PMID: 24473635, DOI: 10.1007/s00592-014-0556-4.Peer-Reviewed Original ResearchConceptsType 1 diabetes incidenceType 1 diabetesHospital Discharge RegistryDiabetes incidenceDischarge RegistryFirst hospitalizationFirst hospitalization ratesPublic health purposesIncident hospitalizationHospitalization ratesCalendar periodPrevalent casesFirst episodeHospitalizationDiabetesOverall populationNational ratesIncidenceAge rangeYear residentsHealth purposesNational dataRegistryRecord linkage procedureChildren
2013
Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR?
Grasso V, Colombo C, Favalli V, Galderisi A, Rabbone I, Gombos S, Bonora E, Massa O, Meschi F, Cerutti F, Iafusco D, Bonfanti R, Monciotti C, Barbetti F. Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR? Acta Diabetologica 2013, 50: 951-957. PMID: 23824322, DOI: 10.1007/s00592-013-0490-x.Peer-Reviewed Case Reports and Technical NotesConceptsSevere insulin resistanceRabson-Mendenhall syndromeDonohue syndromePatient 3Insulin resistanceAbsence of hypertensionGene mutationsINSR mutationsInsulin receptor gene mutationsBartter-like syndromeBartter syndrome type IIReceptor gene mutationsYear of birthSevere hirsutismClinical featuresFifth patientPotassium supplementationAcanthosis nigricansHyperreninemic hyperaldosteronismRenal abnormalitiesCongenital syndromePatientsPubertal femalesSyndromeINSR gene
2012
Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study
Nisticò L, Iafusco D, Galderisi A, Fagnani C, Cotichini R, Toccaceli V, Stazi M, Endocrinology and Diabetology T. Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: e1483-e1491. PMID: 22569240, DOI: 10.1210/jc.2011-3457.Peer-Reviewed Original ResearchConceptsProband-wise concordanceType 1 diabetes susceptibilityDiabetic twinsDiabetes susceptibilityRecurrence riskPediatric diabetes care centersRecent onset casesDiabetes care centerKaplan-Meier methodZinc transporter 8Type 1 diabetesEarly postnatal lifeEarly environmental factorsMean ageCare centerDiabetes recordsProband diagnosisPostnatal lifeTransporter 8Twin cohortType 1Median yearsDiagnosisTwin RegistryDizygotic pairs