2019
Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions
Sherr J, Buckingham BA, Forlenza G, Galderisi A, Ekhlaspour L, Wadwa RP, Carria L, Hsu L, Berget C, Peyser TA, Lee JB, O'Connor J, Dumais B, Huyett L, Layne JE, Ly TT. Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions. Diabetes Technology & Therapeutics 2019, 22: 174-184. PMID: 31596130, PMCID: PMC7047109, DOI: 10.1089/dia.2019.0286.Peer-Reviewed Original ResearchConceptsDaily physical activityPhysical activityFree-living conditionsPercentage timeMultiple daily injectionsType 1 diabetesRespective age groupsCohort of participantsHybrid closed-loop systemPrimary endpointDaily injectionsEligible participantsClosed-loop studiesPercentage of timeTherapy phaseInvestigational deviceNights of useAge groupsSensor glucoseType 1Home settingDlSignificant decreaseUsual routineAdults1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation
SCHIAVON M, GALDERISI A, KRAEMER K, COBELLI C, MAN C, CENGIZ E. 1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation. Diabetes 2019, 68 DOI: 10.2337/db19-1054-p.Peer-Reviewed Original ResearchContinuous glucose monitoringInsulin sensitivityType 1 diabetesEuropean Medical Information FrameworkInsulin pump dataClosed-loop treatmentOral minimal modelMannKind CorporationSequential mealsInsulin therapyMeal studyPlasma glucoseGlycemic outcomesType 1Glucose monitoringSpeakers bureauMeal variationT1D.T1DInternational SocietyAdvisory PanelPump dataTreatmentSI indexDiabetes215-OR: Safety and Performance of the Omnipod Hybrid Closed-Loop System in Young Children Aged 2-6 Years with Type 1 Diabetes
BUCKINGHAM B, FORLENZA G, SHERR J, GALDERISI A, EKHLASPOUR L, LEE J, OCONNOR J, DUMAIS B, HUYETT L, LAYNE J, LY T. 215-OR: Safety and Performance of the Omnipod Hybrid Closed-Loop System in Young Children Aged 2-6 Years with Type 1 Diabetes. Diabetes 2019, 68 DOI: 10.2337/db19-215-or.Peer-Reviewed Original ResearchDiabetes careMedtronic MiniMedSevere hypoglycemic eventsChildren Aged 2Advisory PanelYoung childrenMin/dAge 4.2Oral carbohydrateHybrid closed-loop systemHypoglycemic eventsGlycemic outcomesMean glucoseAged 2CGM useTherapy phaseInvestigational deviceType 1T1D therapyPercent timeMiniMedLexicon PharmaceuticalsCareUsual routineAdult participants
2016
The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulin
Del Rizzo M, Galderisi A, Celato A, Furlan F, Giordano L, Cazzorla C, Fasan I, Moretti C, Zschocke J, Burlina A. The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulin. European Journal Of Pediatrics 2016, 175: 1123-1128. PMID: 26847429, DOI: 10.1007/s00431-016-2699-5.Peer-Reviewed Case Reports and Technical NotesConceptsType 1 diabetes mellitusGlutaric aciduria type 1Diabetes mellitusType 1Metabolic disordersInsulin daily doseIrreversible neuronal damageLong-term treatmentSimilar pathogenic mechanismsDifferent metabolic disordersBilateral striatal necrosisMonths of ageEffect of insulinAcute hypotoniaClassical T1DMLimb dystoniaNeurological outcomeInfective episodesNeuronal injuryDaily doseNeuronal damageDystonic movementsHypoglycemic episodesCarnitine supplementationGlycemic profile
2015
Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes
Lipes M, Galderisi A. Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes. Current Diabetes Reports 2015, 15: 30. PMID: 25821130, PMCID: PMC4376963, DOI: 10.1007/s11892-015-0598-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular diseaseHeart diseaseChronic myocardial inflammationPoor CVD outcomesUnderstanding of CVDType 1 diabetesCardiac autoimmunityMicrovascular complicationsCVD outcomesMyocardial inflammationClinical evidenceHeart syndromeExcess mortalityClinical studiesNovel biomarkersT1DTherapeutic implicationsTherapeutic targetType 2Type 1Same diseaseT2D.DiseaseDiagnostic assaysT1D.
2012
Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study
Nisticò L, Iafusco D, Galderisi A, Fagnani C, Cotichini R, Toccaceli V, Stazi M, Endocrinology and Diabetology T. Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: e1483-e1491. PMID: 22569240, DOI: 10.1210/jc.2011-3457.Peer-Reviewed Original ResearchConceptsProband-wise concordanceType 1 diabetes susceptibilityDiabetic twinsDiabetes susceptibilityRecurrence riskPediatric diabetes care centersRecent onset casesDiabetes care centerKaplan-Meier methodZinc transporter 8Type 1 diabetesEarly postnatal lifeEarly environmental factorsMean ageCare centerDiabetes recordsProband diagnosisPostnatal lifeTransporter 8Twin cohortType 1Median yearsDiagnosisTwin RegistryDizygotic pairs
2011
Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study
Iafusco D, Galderisi A, Nocerino I, Cocca A, Zuccotti G, Prisco F, Scaramuzza A. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study. Diabetes Technology & Therapeutics 2011, 13: 551-555. PMID: 21406010, DOI: 10.1089/dia.2010.0188.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAttitude to HealthChildChild BehaviorDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlycated HemoglobinHealth BehaviorHumansInternetItalyMalePatient CompliancePatient Education as TopicQuality of LifeReproducibility of ResultsSelf CareSurveys and Questionnaires