2023
In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensing
Libera A, Toffanin C, Drecogna M, Galderisi A, Pillonetto G, Cobelli C. In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensing. APL Bioengineering 2023, 7: 026105. PMID: 37229215, PMCID: PMC10205143, DOI: 10.1063/5.0145446.Peer-Reviewed Original ResearchIP insulin deliveryInsulin deliveryPeritoneal spaceMeal announcementChronic autoimmune diseaseInsulin kineticsParadigm of treatmentBeta-cell functionIntraperitoneal insulin deliveryType 1 diabetesInpatient trialPeripheral hyperinsulinemiaMacrovascular complicationsGlycemic controlTwo-compartment modelInsulin replacementAutoimmune diseasesInsulin delivery systemsInsulin secretionDaily burdenInsulin pumpAid useCell functionArtificial pancreasDiseaseEarly treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant
Galderisi A, Kermorvant‐Duchemin E, Daruich A, Bonnard A, Lapillonne A, Aubelle M, Perrella B, Vial Y, Cave H, Berdugo M, Jarreau P, Polak M, Beltrand J. Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant. 2023, 64: 161-166. PMID: 36873092, PMCID: PMC9981413, DOI: 10.1002/jmd2.12358.Peer-Reviewed Original ResearchEarly treatmentNeonatal diabetesPreterm babiesPreterm infantsGlucose profilesComplete retinal vascularizationLow glucose intakeBlood glucose testMonth of birthOral glibenclamideGlycemic controlMonth 6Gestational ageNasogastric tubeRetinal vascularizationMaternal milkGlucose intakeInsulin treatmentKCNJ11 genesGlucose testHyperglycemic episodesSpecific treatmentProgressive regressionDiabetesHomozygous variant
2022
SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance.
Galderisi A, Tamborlane W, Taylor SI, Attia N, Moretti C, Barbetti F. SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance. Pediatrics 2022, 150 PMID: 35652305, DOI: 10.1542/peds.2021-055671.Peer-Reviewed Original ResearchConceptsRabson-Mendenhall syndromeGlycemic controlHemoglobin A1cRenal calcium excretionInsulin-resistant diabetesSevere insulin resistanceCalcium excretionUrinary calciumAntidiabetic treatmentDay doseDose escalationSecond patientFirst patientInsulin levelsInsulin resistanceUrinary excretionSerum glucosePatientsEmpagliflozinMild increaseDapagliflozinΒ-hydroxybutyrateTarget rangeA1CExcretionIntraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling
Presti J, Galderisi A, Doyle F, Zisser H, Dassau E, Renard E, Toffanin C, Cobelli C. Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling. Journal Of Diabetes Science And Technology 2022, 17: 751-756. PMID: 35144503, PMCID: PMC10210098, DOI: 10.1177/19322968221076559.Peer-Reviewed Original ResearchConceptsInsulin deliveryClosed-loop insulin deliveryInsulin kineticsIntraperitoneal insulin deliveryPeripheral hyperinsulinemiaGlycemic controlSubcutaneous routePeritoneal compartmentModel predictive controllerPhysiological routeArtificial pancreasCompartmental modelingDeliveryUVA/Padova T1D simulatorCompartmental modelProportional integral derivative (PID) controllerHyperinsulinemiaThe BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm Neonates
Brigadoi S, Galderisi A, Guiducci S, Cusinato M, Res G, Avagliano L, Sandonà A, Savio F, Di Giorgio E, Priante E, Baraldi E. The BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm Neonates. 2022, otu4d.2. DOI: 10.1364/ots.2022.otu4d.2.Peer-Reviewed Original Research
2019
A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes.
Galderisi A, Sherr JL. A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes. Pediatric Annals 2019, 48: e311-e318. PMID: 31426099, DOI: 10.3928/19382359-20190725-03.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsContinuous glucose monitoringType 1 diabetesGlycemic controlContinuous subcutaneous insulin infusion pumpClosed-loop insulin deliveryIntensive insulin treatmentMultiple daily injectionsChronic medical conditionsLoop insulin deliveryPediatric clinical practiceInsulin infusion pumpDaily injectionsBlood glucoseInsulin treatmentMedical conditionsDiabetes treatmentClinical practiceNew treatmentsGlucose monitoringInfusion pumpInsulin deliveryT1DDiabetesTreatmentSuspension deviceMapping hemodynamic changes during hypoglycemia in the very preterm neonatal brain: preliminary results
Brigadoi S, Galderisi A, Pieropan E, Cooper R, Cutini S, Baraldi E, Cobelli C, Dell'Acqua R, Sparacino G, Trevisanuto D. Mapping hemodynamic changes during hypoglycemia in the very preterm neonatal brain: preliminary results. Progress In Biomedical Optics And Imaging 2019, 11074: 110740e-110740e-3. DOI: 10.1117/12.2526974.Peer-Reviewed Original ResearchVery preterm neonatesSevere hypoglycemic eventsHypoglycemic eventsContinuous glucose monitoringPreterm neonatesHemodynamic changesMild hypoglycemic eventsPoor neurological outcomePreterm neonatal brainTight glycemic controlFuture clinical trialsNeurological outcomeGlycemic controlPreterm populationVery pretermGlycemic variabilityClinical trialsNeonatal brainNewborn brainClinical problemHypoglycemiaHyperglycemic eventsFirst weekBrain hemodynamicsGlucose monitoring
2011
Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study
Iafusco D, Galderisi A, Nocerino I, Cocca A, Zuccotti G, Prisco F, Scaramuzza A. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study. Diabetes Technology & Therapeutics 2011, 13: 551-555. PMID: 21406010, DOI: 10.1089/dia.2010.0188.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAttitude to HealthChildChild BehaviorDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlycated HemoglobinHealth BehaviorHumansInternetItalyMalePatient CompliancePatient Education as TopicQuality of LifeReproducibility of ResultsSelf CareSurveys and Questionnaires