2024
Impact of macronutrients intake on glycemic homeostasis of preterm infants: evidence from continuous glucose monitoring
Guiducci S, Res G, Bonadies L, Savio F, Brigadoi S, Priante E, Trevisanuto D, Baraldi E, Galderisi A. Impact of macronutrients intake on glycemic homeostasis of preterm infants: evidence from continuous glucose monitoring. European Journal Of Pediatrics 2024, 183: 3013-3018. PMID: 38637447, PMCID: PMC11192807, DOI: 10.1007/s00431-024-05532-4.Peer-Reviewed Original ResearchPreterm infantsMacronutrient intakeGlucose profilesGestational ageContinuous glucose monitoringNutritional intakeParenteral nutrient intakesGlycemic homeostasisWeeks gestational ageSensor glucoseExposure to hyperglycemiaGlucose monitoringBlood glucose profilesParenteral nutritionHigher lipid intakeMild hypoglycemiaAmino acid intakeSevere hyperglycemiaSevere hypoglycemiaAcid intakeLipid intakeNutrient intakeInfantsPretermHyperglycemia
2023
Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring
Galderisi A, Kariyawasam D, Stoupa A, Quoc A, Pinto G, Viaud M, Brabant S, Beltrand J, Polak M, Samara-Boustani D. Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring. European Journal Of Endocrinology 2023, 189: k19-k24. PMID: 37952170, DOI: 10.1093/ejendo/lvad147.Peer-Reviewed Original ResearchConceptsClassical congenital adrenal hyperplasiaClassical CAHCongenital adrenal hyperplasiaContinuous glucose monitoringLower cortisol concentrationsGlucose patternsAdrenal hyperplasiaCortisol concentrationsGlucose monitoringFludrocortisone replacement therapySensor glucose valuesHydrocortisone doseAcute illnessAsymptomatic hypoglycemiaWhole cohortNighttime hypoglycemiaReplacement therapyPercentage of timeObservational studyGlucose profilesGlycemic patternsSerial measuresGlucose valuesDaily cortisolHypoglycemiaQuantifying beta cell function in the preclinical stages of type 1 diabetes
Galderisi A, Carr A, Martino M, Taylor P, Senior P, Dayan C. Quantifying beta cell function in the preclinical stages of type 1 diabetes. Diabetologia 2023, 66: 2189-2199. PMID: 37712956, PMCID: PMC10627950, DOI: 10.1007/s00125-023-06011-5.Peer-Reviewed Original ResearchConceptsType 1 diabetesBeta-cell functionInsulin secretionFunctional beta-cell massEarly pre-symptomatic stagesCell functionPre-symptomatic phaseBeta-cell massDisease-modifying interventionsPre-symptomatic stageContinuous glucose monitoringIslet autoimmunityInsulin sensitivityDisease progressionGlucose profilesInvasive measuresPreclinical stageMetabolic testsProgressive lossDiabetesMetabolic changesGlucose monitoringAvailable testsMeasurable changesOGTTEarly treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant
Galderisi A, Kermorvant‐Duchemin E, Daruich A, Bonnard A, Lapillonne A, Aubelle M, Perrella B, Vial Y, Cave H, Berdugo M, Jarreau P, Polak M, Beltrand J. Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant. 2023, 64: 161-166. PMID: 36873092, PMCID: PMC9981413, DOI: 10.1002/jmd2.12358.Peer-Reviewed Original ResearchEarly treatmentNeonatal diabetesPreterm babiesPreterm infantsGlucose profilesComplete retinal vascularizationLow glucose intakeBlood glucose testMonth of birthOral glibenclamideGlycemic controlMonth 6Gestational ageNasogastric tubeRetinal vascularizationMaternal milkGlucose intakeInsulin treatmentKCNJ11 genesGlucose testHyperglycemic episodesSpecific treatmentProgressive regressionDiabetesHomozygous variant