2023
Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
Santoro N, Galderisi A, Caprio S. Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics. 2023, 608-616. DOI: 10.1201/9781003437673-70.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseType 2 diabetesInsulin resistanceAdolescent obesityCardiometabolic risk factorsMajor global health challengeFatty liver diseaseDevelopment of prediabetesGlobal health challengeClinical peculiaritiesFatty liverLiver diseasePediatric obesityRisk factorsPrecocious pubertyMetabolic disordersPathological complicationsObesityHealth challengesPsychosocial conditionsPotential mechanismsDiabetesEarly ageChildrenDyslipidemiaQuantifying beta cell function in the preclinical stages of type 1 diabetes
Galderisi A, Carr A, Martino M, Taylor P, Senior P, Dayan C. Quantifying beta cell function in the preclinical stages of type 1 diabetes. Diabetologia 2023, 66: 2189-2199. PMID: 37712956, PMCID: PMC10627950, DOI: 10.1007/s00125-023-06011-5.Peer-Reviewed Original ResearchConceptsType 1 diabetesBeta-cell functionInsulin secretionFunctional beta-cell massEarly pre-symptomatic stagesCell functionPre-symptomatic phaseBeta-cell massDisease-modifying interventionsPre-symptomatic stageContinuous glucose monitoringIslet autoimmunityInsulin sensitivityDisease progressionGlucose profilesInvasive measuresPreclinical stageMetabolic testsProgressive lossDiabetesMetabolic changesGlucose monitoringAvailable testsMeasurable changesOGTTBeta cell function in the early stages of type 1 diabetes: still a long way ahead of us
Galderisi A. Beta cell function in the early stages of type 1 diabetes: still a long way ahead of us. Pediatric Endocrinology Diabetes And Metabolism 2023, 29: 1-3. PMID: 37218722, PMCID: PMC10226454, DOI: 10.5114/pedm.2023.126360.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBeta-cell functionType 1 diabetesIslet autoimmunityCell functionFunctional beta-cell massDisease-modifier drugsUnderlying autoimmune processPre-symptomatic phaseBeta-cell massSymptomatic diabetesAutoimmune processClinical onsetSurrogate markerDiabetes progressionC-peptideInsulin secretionModifier drugsEarly changesDiabetesMetabolic changesDysglycaemiaAutoimmunityT1DOnsetModifier treatmentScreening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis
Weiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis. Diabetes & Metabolism 2023, 49: 101444. PMID: 37030530, DOI: 10.1016/j.diabet.2023.101444.Peer-Reviewed Original ResearchConceptsGlucose tolerance abnormalitiesCystic fibrosis-related diabetesTolerance abnormalitiesCystic fibrosisAnnual oral glucose tolerance testOral glucose tolerance testGlucose tolerance testLong asymptomatic periodStage of diabetesNew comorbiditiesAsymptomatic periodClinical profileTolerance testNew diagnostic toolsPathophysiological knowledgeDiabetesNutritional outcomesPatientsFibrosisAbnormalitiesScreening strategyLife expectancyDiagnostic toolScreening methodComorbiditiesEarly treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant
Galderisi A, Kermorvant‐Duchemin E, Daruich A, Bonnard A, Lapillonne A, Aubelle M, Perrella B, Vial Y, Cave H, Berdugo M, Jarreau P, Polak M, Beltrand J. Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant. 2023, 64: 161-166. PMID: 36873092, PMCID: PMC9981413, DOI: 10.1002/jmd2.12358.Peer-Reviewed Original ResearchEarly treatmentNeonatal diabetesPreterm babiesPreterm infantsGlucose profilesComplete retinal vascularizationLow glucose intakeBlood glucose testMonth of birthOral glibenclamideGlycemic controlMonth 6Gestational ageNasogastric tubeRetinal vascularizationMaternal milkGlucose intakeInsulin treatmentKCNJ11 genesGlucose testHyperglycemic episodesSpecific treatmentProgressive regressionDiabetesHomozygous variant
2019
A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes.
Galderisi A, Sherr JL. A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes. Pediatric Annals 2019, 48: e311-e318. PMID: 31426099, DOI: 10.3928/19382359-20190725-03.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsContinuous glucose monitoringType 1 diabetesGlycemic controlContinuous subcutaneous insulin infusion pumpClosed-loop insulin deliveryIntensive insulin treatmentMultiple daily injectionsChronic medical conditionsLoop insulin deliveryPediatric clinical practiceInsulin infusion pumpDaily injectionsBlood glucoseInsulin treatmentMedical conditionsDiabetes treatmentClinical practiceNew treatmentsGlucose monitoringInfusion pumpInsulin deliveryT1DDiabetesTreatmentSuspension device1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation
SCHIAVON M, GALDERISI A, KRAEMER K, COBELLI C, MAN C, CENGIZ E. 1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation. Diabetes 2019, 68 DOI: 10.2337/db19-1054-p.Peer-Reviewed Original ResearchContinuous glucose monitoringInsulin sensitivityType 1 diabetesEuropean Medical Information FrameworkInsulin pump dataClosed-loop treatmentOral minimal modelMannKind CorporationSequential mealsInsulin therapyMeal studyPlasma glucoseGlycemic outcomesType 1Glucose monitoringSpeakers bureauMeal variationT1D.T1DInternational SocietyAdvisory PanelPump dataTreatmentSI indexDiabetesChapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential Implications
Galderisi A, Martino M, Santoro N. Chapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential Implications. 2019, 91-99. DOI: 10.1016/b978-0-323-55138-0.00011-5.BooksNonalcoholic fatty liver diseaseFatty liver diseaseType 2 diabetesLiver diseasePediatric nonalcoholic fatty liver diseasePathophysiology of NAFLDEnd-stage liver diseaseIndependent risk factorPathophysiologic linkCommon complicationSimple steatosisPediatric obesityInsulin resistanceRisk factorsType 2Disease severityDiseaseDiabetesWide spectrumComplicationsPotential implicationsSteatosisObesityPathophysiologySeverity
2017
Metabolomics reveals new metabolic perturbations in children with type 1 diabetes
Galderisi A, Pirillo P, Moret V, Stocchero M, Gucciardi A, Perilongo G, Moretti C, Monciotti C, Giordano G, Baraldi E. Metabolomics reveals new metabolic perturbations in children with type 1 diabetes. Pediatric Diabetes 2017, 19: 59-67. PMID: 28401628, DOI: 10.1111/pedi.12524.Peer-Reviewed Original ResearchConceptsBody mass indexType 1 diabetesHealthy controlsPubertal statusExcess of cortisolMetabolome of childrenPediatric diabetes clinicMacrovascular complicationsDiabetes clinicDisease durationNeuronal damagePediatric patientsClinical featuresMass indexCase groupTryptophan catabolitesHealthy peersUrinary metabolitesUrinary samplesBacterial productsT1DUntargeted metabolomics approachMetabolic perturbationsDiabetesPatients
2016
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013
Cherubini V, Skrami E, Ferrito L, Zucchini S, Scaramuzza A, Bonfanti R, Buono P, Cardella F, Cauvin V, Chiari G, d′Annunzio G, Frongia A, Iafusco D, Patera I, Toni S, Tumini S, Rabbone I, Lombardo F, Carle F, Gesuita R, Lera R, De Luna L, Gualtieri A, Zecchino C, Piccinno E, Reinstadler P, Prandi E, Gallo F, Morganti G, Ripoli C, La Loggia A, Scanu P, Cardinale G, Tomaselli L, Citriniti F, Lazzaro N, De Donno V, Mainetti B, Coccioli M, Maccioni R, Marongiu U, Bruzzese M, Iannilli A, Pardi D, Confetto S, Zanfardino A, Iughetti L, Franzese A, Cadario F, Milia A, Piredda G, Soro M, Correddu A, Galderisi A, De Berardinis F, Federico G, Zanette G, Suprani T, Pedini A, Bitti M, Delvecchio M, Trada M, Meloni G, Gaiero A, Bulciolu P, Guerraggio L, Faleschini E, Zanatta M, Salvatoni A, Maffeis C, Arnaldi C. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013. Scientific Reports 2016, 6: 38844. PMID: 27991500, PMCID: PMC5171855, DOI: 10.1038/srep38844.Peer-Reviewed Original ResearchConceptsSevere diabetic ketoacidosisDiabetic ketoacidosisType 1 diabetesDKA frequencyAge groupsLongitudinal population-based studyType 1 diabetes diagnosisMultiple logistic regression modelPopulation-based studyNationwide longitudinal studyYears of ageLogistic regression modelsItalian childrenFamily historyHigh riskMild/Diabetes diagnosisKetoacidosisHealthcare strategiesYoung age childrenDiabetesEarly detectionDiagnosisLongitudinal studyTime trendsRandomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe
Del Favero S, Boscari F, Messori M, Rabbone I, Bonfanti R, Sabbion A, Iafusco D, Schiaffini R, Visentin R, Calore R, Moncada Y, Galasso S, Galderisi A, Vallone V, Di Palma F, Losiouk E, Lanzola G, Tinti D, Rigamonti A, Marigliano M, Zanfardino A, Rapini N, Avogaro A, Chernavvsky D, Magni L, Cobelli C, Bruttomesso D. Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe. Diabetes Care 2016, 39: 1180-1185. PMID: 27208335, DOI: 10.2337/dc15-2815.Peer-Reviewed Original ResearchConceptsSensor-augmented pumpCrossover trialMean glucoseArtificial pancreasType 1 diabetesArtificial Pancreas ProjectWearable artificial pancreasAP trialOlder childrenTrialsHypoglycemiaYoung childrenChildrenPancreasOvernight timeSignificant changesGlucoseDaysDiabetesOutpatientsResearch designThreefold reduction
2014
An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR)
Vichi M, Iafusco D, Galderisi A, Stazi M, Nisticò L. An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR). Acta Diabetologica 2014, 51: 287-294. PMID: 24473635, DOI: 10.1007/s00592-014-0556-4.Peer-Reviewed Original ResearchConceptsType 1 diabetes incidenceType 1 diabetesHospital Discharge RegistryDiabetes incidenceDischarge RegistryFirst hospitalizationFirst hospitalization ratesPublic health purposesIncident hospitalizationHospitalization ratesCalendar periodPrevalent casesFirst episodeHospitalizationDiabetesOverall populationNational ratesIncidenceAge rangeYear residentsHealth purposesNational dataRegistryRecord linkage procedureChildren
2012
Mitochondrial Diabetes in Children: Seek and You Will Find It
Mazzaccara C, Iafusco D, Liguori R, Ferrigno M, Galderisi A, Vitale D, Simonelli F, Landolfo P, Prisco F, Masullo M, Sacchetti L. Mitochondrial Diabetes in Children: Seek and You Will Find It. PLOS ONE 2012, 7: e34956. PMID: 22536343, PMCID: PMC3334935, DOI: 10.1371/journal.pone.0034956.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCase-Control StudiesChildChild, PreschoolDeafnessDiabetes Mellitus, Type 2Electron Transport Complex IElectron Transport Complex IVFemaleGenes, MitochondrialGenetic Association StudiesGenome, MitochondrialHumansMaleMitochondriaMitochondrial DiseasesPedigreeSequence Analysis, DNAConceptsMitochondrial diabetesHitherto unknown associationMaternally Inherited DiabetesDiabetes/Most patientsDiabetic childrenDiabetic adolescentsCeliac diseaseInherited DiabetesComplex syndromeDiabetic phenotypeRare formDiabetesPathogenic significanceMacular dystrophyHearing impairmentPatientsG variantMaculopathyChildrenMothersDiseaseImpairmentDeafnessUnknown association
2011
Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study
Iafusco D, Galderisi A, Nocerino I, Cocca A, Zuccotti G, Prisco F, Scaramuzza A. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study. Diabetes Technology & Therapeutics 2011, 13: 551-555. PMID: 21406010, DOI: 10.1089/dia.2010.0188.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAttitude to HealthChildChild BehaviorDiabetes Mellitus, Type 1FemaleFollow-Up StudiesGlycated HemoglobinHealth BehaviorHumansInternetItalyMalePatient CompliancePatient Education as TopicQuality of LifeReproducibility of ResultsSelf CareSurveys and Questionnaires