2022
Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders
Bernhisel A, Siddon A, Katz S. Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders. American Journal Of Clinical Pathology 2022, 158: s105-s105. DOI: 10.1093/ajcp/aqac126.221.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaIRF4 rearrangementB cellsCD30-positive T-cell lymphoproliferative disordersT-cell lymphoproliferative disorderLarge B-cell lymphomaPast medical historyT-cell lesionsCell lymphoproliferative disordersT-cell disordersB-cell lymphomaT-cell neoplasmsT cell linesIRF4 gene rearrangementT cell developmentLymphomatoid papulosisHodgkin's diseaseHematopoietic progenitor cellsLymphoproliferative disordersIntroduction/ObjectiveCase reportMedical historyCommon lymphoid progenitorsCell lesionsCell neoplasms
2020
The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders
Mendoza H, Tormey CA, Rinder HM, Howe JG, Siddon AJ. The utility and limitations of B- and T-cell gene rearrangement studies in evaluating lymphoproliferative disorders. Pathology 2020, 53: 157-165. PMID: 33358756, DOI: 10.1016/j.pathol.2020.09.024.Peer-Reviewed Original ResearchConceptsTCR gene rearrangement analysisGene rearrangement analysisPolymerase chain reactionRearrangement analysisLymphocyte populationsLymphoid malignanciesT-cell receptor gene rearrangement analysisT-cell gene rearrangement studiesTCR gene rearrangement patternsT cell populationsGene rearrangement studiesNext-generation sequencingGene rearrangement patternsLymphoproliferative disordersEvaluation of Positive B- and T-Cell Gene Rearrangement Studies in Patients With Negative Morphology, Flow Cytometry, and Immunohistochemistry
Mendoza H, Tormey CA, Siddon AJ. Evaluation of Positive B- and T-Cell Gene Rearrangement Studies in Patients With Negative Morphology, Flow Cytometry, and Immunohistochemistry. Archives Of Pathology & Laboratory Medicine 2020, 145: 227-230. PMID: 32886749, DOI: 10.5858/arpa.2019-0663-oa.Peer-Reviewed Original ResearchConceptsGene rearrangement studiesBone marrow studyRearrangement studiesMarrow studiesLymphoproliferative disordersTCR gene rearrangement studiesT-cell receptor gene rearrangement studiesT-cell gene rearrangement studiesNegative bone marrowPeripheral blood findingsIg gene rearrangement studiesPeripheral blood assaysGene rearrangement resultsDate of testingHematologic outcomesBlood findingsFinal diagnosisPositive BSHematologic malignanciesMedical recordsPositive immunoglobulinSubsequent diagnosisBlood assaysDisease processBone marrow
2019
DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma
Wang M, Kibbi N, Ring N, Siddon A, Foss F, Totonchy M. DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma. BMJ Case Reports 2019, 12: e230641. PMID: 31570354, PMCID: PMC6768350, DOI: 10.1136/bcr-2019-230641.Peer-Reviewed Original ResearchConceptsAnaplastic large cell lymphomaPrimary systemic anaplastic large cell lymphomaSystemic anaplastic large cell lymphomaLarge cell lymphomaPoor prognosisSubcutaneous nodulesCell lymphomaGenetic testingALK-negative anaplastic large cell lymphomaBrentuximab vedotin monotherapySetting of HIVHIV-negative patientsCases of AIDSAnaplastic lymphoma kinaseHIV/AIDSComplete remissionDiffuse lymphadenopathyDisease courseFavorable prognosisLymph nodesAggressive lymphomaLymphoproliferative disordersLymphoma kinaseLymphomaAIDS
2013
Pathology Consultation on Evaluating Prognosis in Incidental Monoclonal Lymphocytosis and Chronic Lymphocytic Leukemia
Siddon AJ, Rinder HM. Pathology Consultation on Evaluating Prognosis in Incidental Monoclonal Lymphocytosis and Chronic Lymphocytic Leukemia. American Journal Of Clinical Pathology 2013, 139: 708-712. PMID: 23690112, DOI: 10.1309/ajcplir4gzwx3xka.Peer-Reviewed Original ResearchMeSH KeywordsADP-ribosyl Cyclase 1Beta 2-MicroglobulinFlow CytometryGene Rearrangement, B-LymphocyteHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionIncidental FindingsLeukemia, Lymphocytic, Chronic, B-CellLymphocytosisMaleMiddle AgedMutationPrognosisWatchful WaitingZAP-70 Protein-Tyrosine KinaseConceptsChronic lymphocytic leukemiaEarly-stage chronic lymphocytic leukemiaStage chronic lymphocytic leukemiaDisease progressionLymphocytic leukemiaImmunoglobulin heavy chain variable (IGHV) gene mutational statusMonoclonal B-cell lymphoproliferative disorderLaboratory evaluationOvert chronic lymphocytic leukemiaMonoclonal B-cell lymphocytosisB-cell lymphoproliferative disordersAggressive disease progressionSignificant disease progressionIndolent clinical courseSerum β2-microglobulinRoutine laboratory evaluationB-cell lymphocytosisZAP-70 expressionGene mutational statusMonoclonal lymphocytosisClinical courseExpectant observationLymphoproliferative disordersTherapeutic optionsPrognostic marker